Advertisement

Biochip Architecture Model

  • Paul PopEmail author
  • Wajid Hassan Minhass
  • Jan Madsen
Chapter

Abstract

This chapter presents the biochip architecture models used throughout the book. We first present the microfluidic valve, which is the basic building block of continuous-flow biochips. Microfluidic valves, together with microfluidic channels, are used to build microfluidic components. The chapter presents a microfluidic component model and how we capture the details of the components in a component library. Then, we propose a topology graph model, also called a netlist, which models the components and their interconnections. The chapter also discusses the control of microfluidic biochips using off-chip pressure. In this context, we present recent advances that move the off-chip control on-chip, using microfluidic valves to build logic circuits based on pneumatics.

Keywords

Microfluidic valve Normally closed valve Peristaltic mixer Switch  Microfluidic components On-chip control Logic gates 

References

  1. 1.
    Amin, A.M., Thottethodi, M., Vijaykumar, T.N., Wereley, S., Jacobson, S.C.: Automatic volume management for programmable microfluidics. In: Proceedings of the 2008 ACM SIGPLAN Conference on Programming Language Design and Implementation (2008)Google Scholar
  2. 2.
    Amin, N., Thies, W., Amarasinghe, S.: Computer-aided design for microfluidic chips based on multilayer soft lithography. In: Proceedings of the IEEE International Conference on Computer Design, pp. 2–9 (2009)Google Scholar
  3. 3.
    Chou, H., Unger, M., Quake, S.: A microfabricated rotary pump. Biomed. Microdevices 3, 323–330 (2001)CrossRefGoogle Scholar
  4. 4.
    Devaraju, N.S.G.K., Unger, M.A.: Pressure driven digital logic in PDMS based microfluidic devices fabricated by multilayer soft lithography. Lab Chip 12(22), 4809–4815 (2012)CrossRefGoogle Scholar
  5. 5.
    Grover, W.H., Mathies, R.A.: Monolithic membrane valves and pumps. In: Herold, K.E., Rasooly, A. (eds.) Lab-on-a-Chip Technology. Fabrication and Microfluidics, vol. 1. Caister Academic Press, Norfolk (2009)Google Scholar
  6. 6.
    Grover, W.H., Skelley, A.M., Liu, C.N., Lagally, E.T., Mathies, R.A.: Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices. Sens. Actuators B: Chem. 89(3), 315–323 (2003)CrossRefGoogle Scholar
  7. 7.
    Grover, W.H., Ivester, R.H., Jensen, E.C., Mathies, R.A.: Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab Chip 6(5), 623–631 (2006)CrossRefGoogle Scholar
  8. 8.
    Hosokawa, K., Maeda, R.: A pneumatically-actuated three-way microvalve fabricated with polydimethylsiloxane using the membrane transfer technique. J. Micromech. Microeng. 10(3), 415 (2000)CrossRefGoogle Scholar
  9. 9.
    Jensen, E.C.: Fluidic microvalve digital processors for automated biochemical analysis (2011)Google Scholar
  10. 10.
    Klammer, I., Buchenauer, A., Fassbender, H., Schlierf, R., Dura, G., Mokwa, W., Schnakenberg, U.: Numerical analysis and characterization of bionic valves for microfluidic PDMS-based systems. J. Micromech. Microeng. 17(7), S122–S127 (2007)CrossRefGoogle Scholar
  11. 11.
    Lim, Y.C., Kouzani, A.Z., Duan, W.: Lab-on-a-chip: a component view. J. Microsyst. Technol. 16(12), 1995–2015 (2010)CrossRefGoogle Scholar
  12. 12.
    Mathies, R., Grover, W., Jensen, E.: Multiplexed latching valves for microfluidic devices and processors (2007). US Patent App. 11/726,701. https://www.google.com/patents/US20070237686
  13. 13.
    Melin, J., Quake, S.: Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu. Rev. Biophys. Biomol. Struct. 36, 213–231 (2007)CrossRefGoogle Scholar
  14. 14.
    Minhass, W., Pop, P., Madsen, J.: System-level modeling and synthesis techniques for flow-based microfluidic very large scale integration biochips. Ph.D. thesis, Technical University of Denmark, DTU (2012)Google Scholar
  15. 15.
    Nguyen, T., Ahrar, S., Duncan, P., Hui, E.: Microfluidic finite state machine for autonomous control of integrated fluid networks. In: Proceedings of Micro Total Analysis Systems, pp. 741–743Google Scholar
  16. 16.
    Raagaard, M.L., Pop, P.: Pin count-aware biochemical application compilation for mVLSI biochips, pp. 1–6 (2015)Google Scholar
  17. 17.
    Siegrist, J., Amasia, M., Singh, N., Banerjee, D., Madou, M.: Numerical modeling and experimental validation of uniform microchamber filling in centrifugal microfluidics. Lab Chip 10, 876–886 (2010)CrossRefGoogle Scholar
  18. 18.
    Unger, M.A., Chou, H., Thorsen, T., Scherer, A., Quake, S.R.: Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288(5463), 113–116 (2000)CrossRefGoogle Scholar
  19. 19.
    Urbanski, J.P., Thies, W., Rhodes, C., Amarasinghe, S., Thorsen, T.: Digital microfluidics using soft lithography. Lab Chip 6(1), 96–104 (2006)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Technical University of DenmarkKongens LyngbyDenmark

Personalised recommendations