Abstract
Rippling muscle disorders are myopathies with signs of muscle hyperexcitability characterized by a peculiar rolling, wavelike phenomena across muscles that can be induced by stretch or percussion. An acquired autoimmune form of the disorder has been described with rippling muscles associated with myasthenia gravis both with and without thymoma. The clinical phenomena of rippling muscles with acquired autoimmune rippling muscles (ARM) are identical to that previously described with inherited rippling muscle disease (RMD). The latter will be described in this chapter as background for the more recently described acquired autoimmune rippling muscles with myasthenia gravis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Readings
Ansevin CF, Agamanolis DP (1996) Rippling muscles and myasthenia gravis with rippling muscles. Arch Neurol 53:197–199
Betz RC, Schoser BG, Kasper D et al (2001) Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease. Nat Genet 28(3):218–219
Muller-Felber W, Ansevin CF, Ricker K et al (1999) Immunosuppressive treatment of rippling muscles in patients with myasthenia gravis. Neuromuscul Disord 9:604–607
Ricker K, Moxley RT, Rohkamm R (1989) Rippling muscle disease. Arch Neurol 46(4):405–408
Schoser B, Jacob S, Hilton-Jones D et al (2009) Immune-mediated rippling muscle disease with myasthenia gravis: a report of seven patients with long-term follow-up in two. Neuromuscul Disord 19:223–228
Torbergsen T (1975) A family with dominant hereditary myotonia, muscular hypertrophy, and increased muscular irritability, distinct from myotonia congenita Thomsen. Acta Neurol Scand 51(3):225–232
Vorgerd M, Bolz H, Patzold T et al (1999) Phenotypic variability in rippling muscle disease. Neurology 52(7):1453–1459
Watkins TC, Zelinka L, Kesic M et al (2006) Identification of skeletal muscle autoantigens by expression library screening using sera from autoimmune rippling muscle disease (ARMD) patients. J Cell Biochem 99(1):79–87
Zelinka L, McCann S, Budde J, Sethi S, Guidos M, Giles R, Walker GR (2011) Expression of the autoimmune rippling muscle disease immunogenic domain of human titin encoded by exons 248–249. Biochem Biophys Res Commun 411:501–505
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Ansevin, C.F. (2016). Acquired Autoimmune Rippling Muscles with Myasthenia Gravis. In: Angelini, C. (eds) Acquired Neuromuscular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-29514-5_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-29514-5_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-29512-1
Online ISBN: 978-3-319-29514-5
eBook Packages: MedicineMedicine (R0)