Ocular Permeation Enhancers

  • Nathaniel J. Kim
  • Alon HarrisEmail author
  • Alhasan Elghouche
  • Willy Gama
  • Brent Siesky


Nanotechnology-based penetration enhancers provide novel mechanisms to improve current drug delivery methodologies. New developments in this field have been shown to overcome previous difficulties of ocular therapeutics like anatomical barriers and filtration mechanisms. Furthermore, nanoparticles exhibit additional benefits as a drug carrier, such as protection of drugs against degradation, biocompatible carrier structures, or reduction of adverse or immunological effects. Penetration enhancers exhibit great promise in ophthalmology. While much of the current research in the field surrounds lipid-based nanotechnologies, other innovative works have expanded the spectrum of ocular drug delivery.

This chapter investigates the most current work in the field of nanotechnology-based ocular penetration enhancers that have laid the foundation for future investigations. In addition to nanoparticle constructs, drug delivery techniques that may be used in conjunction with nanoparticles are also explored.


Drug delivery Ocular barrier Penetration enhancer Nanobiomaterials Iontophoresis Implants Microsphere Microneedle 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Nathaniel J. Kim
    • 1
  • Alon Harris
    • 2
    Email author
  • Alhasan Elghouche
    • 1
  • Willy Gama
    • 1
  • Brent Siesky
    • 1
  1. 1.Department of OphthalmologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Department of OphthalmologyIndiana University School of MedicineIndianapolisUSA

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