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Physicochemical Requirements for Polymers and Polymer-Based Nanomaterial for Ophthalmic Drug Delivery

  • Sheeba Varghese GuptaEmail author
Chapter

Abstract

Polymers used for constructing ophthalmic nanodelivery systems play a crucial role in determining the drug entrapment capacity, biodegradation, and residence time of the nanoparticles. Polymers used for ophthalmic nanodelivery systems are biodegradable; the biodegradation may be enzymatically or chemically mediated. The physicochemical properties of the polymers such as molecular weight, hydrophobicity/hydrophilicity, polymer/copolymer composition, crystallinity, and glass transition temperature affect particle size, entrapment efficiency, adsorption/absorption pattern, degradation kinetics, and mechanical strength of the nanoparticles. PLGA is the most widely used polymer for ophthalmic delivery because of its biodegradability and flexibility in alteration of the physicochemical properties by altering the copolymer composition. Physicochemical properties of a polymer can be altered by chemical modifications. In-depth understanding of the physicochemical properties of the polymers is important to design a nanodelivery system with optimum drug encapsulation, degradation, and residence time.

Keywords

Physicochemical properties Molecular weight Crystallinity Glass transition temperature Biodegradation PLGA 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.College of PharmacyUniversity of South FloridaTampaUSA

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