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Nano-Biomaterials For Ophthalmic Drug Delivery pp 483–494Cite as

Ocular Drug Delivery: Impact of In Vitro Cell Culture Models

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Abstract

The physiological characteristics make effective drug delivery very challenging. Various structures such as the cornea, conjunctival epithelium, blood-retinal barrier (BRB), and the retinal epithelium block or severely reduce the concentration of drugs that can reach particular locations in the eye. Because of this, in vitro models that can effectively model each of these barriers are highly desirable. Such in vitro modeling allows researchers to minimize the use of animal studies, as drug delivery experiments require frequent euthanization. As a substitute for animal experiments, various types of in vitro models have been developed that are made up of primary cell cultures or immortalized cell lines. These cell lines allow for the detailed study of the individual processes that determine the ability of drugs and drug delivery systems to reach their desired locations in therapeutic concentrations. This chapter discusses various examples of such cell lines and their applicability in various drug delivery studies.

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Author information

Authors and Affiliations

  1. Honors College, University of South Florida, Tampa, FL, USA

    Aum Solanki

  2. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Sumir Desai

  3. College of Medicine, University of South Florida, Tampa, FL, USA

    Aditya Grover

  4. Department of Pharmaceutical Sciences, USF College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA

    Anjali Hirani & Yashwant Pathak

  5. School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, VA, 24061, USA

    Anjali Hirani

  6. Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA

    Vijaykumar Sutariya

Authors
  1. Aum Solanki
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  2. Sumir Desai
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  3. Aditya Grover
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  4. Anjali Hirani
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  5. Yashwant Pathak
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  6. Vijaykumar Sutariya
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Corresponding authors

Correspondence to Yashwant Pathak or Vijaykumar Sutariya .

Editor information

Editors and Affiliations

  1. College of Pharmacy, University of South Florida Health, Tampa, Florida, USA

    Yashwant Pathak

  2. College of Pharmacy, University of South Florida Health, Tampa, Florida, USA

    Vijaykumar Sutariya

  3. College of Pharmacy, University of South Florida, Tampa, Florida, USA

    Anjali A. Hirani

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© 2016 Springer International Publishing Switzerland

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Solanki, A., Desai, S., Grover, A., Hirani, A., Pathak, Y., Sutariya, V. (2016). Ocular Drug Delivery: Impact of In Vitro Cell Culture Models. In: Pathak, Y., Sutariya, V., Hirani, A. (eds) Nano-Biomaterials For Ophthalmic Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-319-29346-2_21

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