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Overview of the Ophthalmic System

  • Sharad MalavadeEmail author
Chapter

Abstract

Drug delivery to the eye is a challenging task given the inherent structural and physiological uniqueness of the eye. The eye is a composite organ comprised of unique structures with distinct structure and functions that work together for the perception of sight. Structures like the cornea, the crystalline lens, and the vitreous humor are avascular structures, while the uveal tract is primarily the vascular layer of the eye. The retinal neuro-circuitry is complex and situated deep inside the eye and is a derivative of neuroectoderm. Similar to the blood–brain barrier, there is the blood–retina barrier in the eye. The limited external surface area and the deep isolated location of the different structures of the eye along with avascularity of some of the structures and the blood–retina barrier pose unique challenges for delivery of drugs to intraocular structures.

Keywords

Ocular drug delivery Ocular anatomy Cornea Conjunctiva Sclera Uveal tract Retina 

References

  1. 1.
    Galloway NR, Amoaku WMK, Galloway PH, Browning AC (2006) Basic anatomy and physiology of the eye. In: Common eye diseases and their management. Springer, London, pp 7–15Google Scholar
  2. 2.
    Rathore K, Nema R (2009) An insight into ophthalmic drug delivery system. Int J Pharm Sci Drug Res 1(1):1–5Google Scholar
  3. 3.
    Kawakita T et al (2008) Measurement of fornix depth and area: a novel method of determining the severity of fornix shortening. Eye 23(5):1115–1119CrossRefPubMedGoogle Scholar
  4. 4.
    Obata H (2006) Anatomy and histopathology of the human lacrimal gland. Cornea 25(Supp. 1):S82–S89CrossRefPubMedGoogle Scholar
  5. 5.
    Fleiszig SM, McNamara NA, Evans DJ (2002) The tear film and defense against infection. Adv Exp Med Biol 506(Pt A):523–530PubMedGoogle Scholar
  6. 6.
    Kijlstra A, Kuizenga A (1994) Analysis and function of the human tear proteins. Adv Exp Med Biol 350:299–308CrossRefPubMedGoogle Scholar
  7. 7.
    Bron AJ et al (2004) Functional aspects of the tear film lipid layer. Exp Eye Res 78(3):347–360CrossRefPubMedGoogle Scholar
  8. 8.
    Heindl L et al (2008) Surgical anatomy and pathology in surgery of the eyelids, lacrimal system, orbit and conjunctiva. In: Naumann GH, Holbach L, Kruse F (eds) Applied pathology for ophthalmic microsurgeons. Springer, Berlin/Heidelberg, pp 29–75CrossRefGoogle Scholar
  9. 9.
    Burkat CN, Lucarelli MJ (2006) Anatomy of the lacrimal system. In: The lacrimal system. Springer, New York, pp 3–19CrossRefGoogle Scholar
  10. 10.
    Diebold Y, Calonge M (2010) Applications of nanoparticles in ophthalmology. Prog Retin Eye Res 29(6):596–609CrossRefPubMedGoogle Scholar
  11. 11.
    Järvinen K, Järvinen T, Urtti A (1995) Ocular absorption following topical delivery. Adv Drug Deliv Rev 16(1):3–19CrossRefGoogle Scholar
  12. 12.
    Komai Y, Ushiki T (1991) The three-dimensional organization of collagen fibrils in the human cornea and sclera. Invest Ophthalmol Vis Sci 32(8):2244–58PubMedGoogle Scholar
  13. 13.
    Lee S-B et al (2004) Drug delivery through the sclera: effects of thickness, hydration, and sustained release systems. Exp Eye Res 78(3):599–607CrossRefPubMedGoogle Scholar
  14. 14.
    Gaudana R et al (2010) Ocular drug delivery. AAPS J 12(3):348–360CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Evans M (2014) Anatomy of the uvea. In: Yanoff M, Duker JS (eds) Ophthalmology. Elsevier Saunders, Philadelphia, pp 687–689Google Scholar
  16. 16.
    Shiuey Y, Jakobiec FA, Friedman E (2000) Uveal physiology and circulatory abnormalities. In A.a.J.A. Gragoudas (ed) Principles and practice of ophthalmology. W.B. Saunders, Philadelphia, pp 1175–1185Google Scholar
  17. 17.
    Giampani, A.S.B.-. and J.G. Junior, Anatomy of Ciliary Body, Ciliary Processes, Anterior Chamber Angle and Collector Vessels. Glaucoma - Basic and Clinical Aspects. 2013. InTech, DOI: 10.5772/52780. Available from: http://www.intechopen.com/books/glaucoma-basic-and-clinical-aspects/anatomy-of-ciliary-body-ciliary-processes-anterior-chamber-angle-and-collector-vesselsGoogle Scholar
  18. 18.
    Allingham RR (2010) Cellular and molecular biology of aqueous humor dynamics. In: Shields textbook of glaucoma. Wolters Kluver Health, Philadelphia, pp 1–23Google Scholar
  19. 19.
    Delamere NA (2006) The lens. In: Tasman W, Jaeger EA (eds) Duane’s foundations of ophthalmology. Lippincott Williams & Wilkins Publishers, Inc, PhiladelphiaGoogle Scholar
  20. 20.
    Worgul BV, Kleiman NJ (2006) Lens. In: Tasman W, Jaeger E (eds) Duane’s foundations of clinical ophthalmology. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
  21. 21.
    Sebag J (2006) Vitreous biochemistry, structure, and clinical evaluation. In: Tasman W, Jaeger E (eds) Duane’s clinical ophthalmology. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
  22. 22.
    Grunwald GB (2006) Structure and function of the retinal pigment epithelium. In: Tasman W, Jaeger E (eds) Duane’s foundations of clinical ophthalmology. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
  23. 23.
    John D et al (2011) Dimensions of the foveal avascular zone using the Heidelberg retinal angiogram-2 in normal eyes. Indian J Ophthalmol 59(1):9–11CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Göran Darius Hildebrand ARF (2011) Anatomy and physiology of the retina. In: Reynolds J, Olitsky S (eds) Springer/Berlin Heidelberg, New YorkGoogle Scholar
  25. 25.
    Park SS (2006) The anatomy and cell biology of the retina. In: Tasman W, Jaeger E (eds) Duane’s foundations of clinical ophthalmology. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
  26. 26.
    Jie Zhang, Rubin RM, Rao NA (2006) Anatomy and embryology of the optic nerve. In: Tasman W, Jaeger EA (eds) Duane’s foundations of clinical ophthalmology. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
  27. 27.
    Sherman DD, Burkat CN, Lemke BN (2006) Orbital anatomy and its clinical applications. In: Tasman W, Jaeger EA (eds) Duane’s clinical ophthalmology. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Global Health, College of Public HealthUniversity of South FloridaTampaUSA

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