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Colloidal Carriers in Ophthalmic Drug Delivery

  • Deepak GuptaEmail author
Chapter

Abstract

Ocular diseases like cataract, glaucoma, retinoblastoma, diabetic retinopathy, retinal degeneration, retinitis pigmentosa, and choroidal neovascularization are the leading causes of blindness all over the world. Drugs for treating eye diseases are limited in their efficacy due to different ocular barriers. Furthermore, most of the drugs show either poor ocular permeation or rapid clearance from the eyes. The use of colloidal carriers such as nanoparticles, dendrimers, and liposomes has shown the potential to overcome these barriers to the usefulness of a drug. Preclinical and a few clinical studies illustrate that these carrier systems are very useful for delivering wide variety of drugs and genes. These carriers have found applications not only in drug delivery but also in imaging and diagnostics. This chapter focuses on some recent developments in these colloidal systems and discusses how drug delivery to both anterior and posterior eye can be optimized by understanding route of delivery and properties of colloidal systems and their suitability based on drug and disease targeted.

Keywords

Colloidal carrier Ophthalmic formulation Ophthalmic drug delivery Nanoparticles Dendrimers Liposomes Niosomes Cubosomes Micelles Intraocular delivery Suprachoroidal delivery Periocular delivery Topical delivery Subconjunctival delivery Anterior eye Posterior eye 

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Associate Professor of Pharmaceutical SciencesL|E|C|O|M Bradenton School of PharmacyBradentonUSA

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