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Acute Blood Pressure Management After Ischemic Stroke

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Hypertension and Stroke

Abstract

Although the long-term treatment of hypertension is effective for secondary stroke prevention, the optimal management of blood pressure in the setting of acute ischemic stroke has been controversial. This chapter discusses the available evidence and current guidelines supporting the management of blood pressure in the setting of acute ischemic stroke. For patients that are candidates for thrombolysis, reduction and maintenance of the BP within the current guidelines is indicated as it likely reduces the risk of hemorrhagic complications. For all other patients, there is no clear benefit and potentially harm for acute blood pressure reduction.

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References

  1. Wallace JD, Levy LL. Blood pressure after stroke. JAMA. 1981;246:2177–80.

    Article  CAS  PubMed  Google Scholar 

  2. Britton M, Carlsson A, de Faire U. Blood pressure course in patients with acute stroke and matched controls. Stroke. 1986;17:861–4.

    Article  CAS  PubMed  Google Scholar 

  3. Qureshi AI, Ezzeddine MA, Nasar A, Suri MFK, Kirmani JF, Hussein HM, Divani AA, Reddi AS. Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med. 2007;25:32–8.

    Article  PubMed  PubMed Central  Google Scholar 

  4. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet 1997;349:1641–49.

    Google Scholar 

  5. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet 1997;349:1569–81.

    Google Scholar 

  6. Harper G, Castleden CM, Potter JF. Factors affecting changes in blood pressure after acute stroke. Stroke. 1994;25:1726–9.

    Article  CAS  PubMed  Google Scholar 

  7. Broderick J, Brott T, Barsan W, Haley EC, Levy D, Marler J, Sheppard G, Blum C. Blood pressure during the first minutes of focal cerebral ischemia. Ann Emerg Med. 1993;22:1438–43.

    Article  CAS  PubMed  Google Scholar 

  8. Chamorro A, Vila N, Ascaso C, Elices E, Schonewille W, Blanc R. Blood pressure and functional recovery in acute ischemic stroke. Stroke. 1998;29:1850–3.

    Article  CAS  PubMed  Google Scholar 

  9. Mattle HP, Kappeler L, Arnold M, Fischer U, Nedeltchev K, Remonda L, Jakob SM, Schroth G. Blood pressure and vessel recanalization in the first hours after ischemic stroke. Stroke. 2005;36:264–8.

    Article  PubMed  Google Scholar 

  10. Vemmos KN, Tsivgoulis G, Spengos K, Zakopoulos N, Synetos A, Manios E, Konstantopoulou P, Mavrikakis M. U-shaped relationship between mortality and admission blood pressure in patients with acute stroke. J Intern Med. 2004;255:257–65.

    Article  CAS  PubMed  Google Scholar 

  11. Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG, IST Collaborative Group. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke. 2002;33:1315–20.

    Article  PubMed  Google Scholar 

  12. Stead LG, Gilmore RM, Vedula KC, Weaver AL, Decker WW, Brown RD. Impact of acute blood pressure variability on ischemic stroke outcome. Neurology. 2006;66:1878–81.

    Article  CAS  PubMed  Google Scholar 

  13. Ahmed N, Wahlgren G. High initial blood pressure after acute stroke is associated with poor functional outcome. J Intern Med. 2001;249:467–73.

    Article  CAS  PubMed  Google Scholar 

  14. Sare GM, Ali M, Shuaib A, Bath PMW, for the VISTA Collaboration. Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA collaboration. Stroke. 2009;40:2098–103.

    Article  PubMed  Google Scholar 

  15. Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T, Investigators FSR. High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry. Hypertension. 2014;63:54–60.

    Article  CAS  PubMed  Google Scholar 

  16. Jensen MB, Yoo B, Clarke WR, Davis PH, Adams HR. Blood pressure as an independent prognostic factor in acute ischemic stroke. Can J Neurol Sci. 2006;33:34–8.

    Article  PubMed  Google Scholar 

  17. Strandgaard S, Paulson OB. Cerebral autoregulation. Stroke. 1984;15:413–6.

    Article  CAS  PubMed  Google Scholar 

  18. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2:161–92.

    CAS  PubMed  Google Scholar 

  19. Lang EW, Lagopoulos J, Griffith J, Yip K, Yam A, Mudaliar Y, Mehdorn HM, Dorsch NWC. Cerebral vasomotor reactivity testing in head injury: the link between pressure and flow. J Neurol Neurosurg Psychiatr. 2003;74:1053–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Agnoli A, Fieschi C, Bozzao L, Battistini N, Prencipe M. Autoregulation of cerebral blood flow. Studies during drug-induced hypertension in normal subjects and in patients with cerebral vascular diseases. Circulation. 1968;38:800–12.

    Article  CAS  PubMed  Google Scholar 

  21. Paulson OB, Lassen NA, Skinhoj E. Regional cerebral blood flow in apoplexy without arterial occlusion. Neurology. 1970;20:125–38.

    Article  CAS  PubMed  Google Scholar 

  22. Paulson OB. Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery. Neurology. 1970;20:63–77.

    Article  CAS  PubMed  Google Scholar 

  23. Pozzilli C, Di Piero V, Pantano P, Rasura M, Lenzi GL. Influence of nimodipine on cerebral blood flow in human cerebral ischaemia. J Neurol. 1989;236:199–202.

    Article  CAS  PubMed  Google Scholar 

  24. Vorstrup S, Andersen A, Blegvad N, Paulson OB. Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke. J Cereb Blood Flow Metab. 1986;6:222–9.

    Article  CAS  PubMed  Google Scholar 

  25. Powers WJ, Videen TO, Diringer MN, Aiyagari V, Zazulia AR. Autoregulation after ischaemic stroke. J Hypertens. 2009;27:2218–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Jauch EC, Saver JL, Adams HP, Bruno A, Connors JJB, Demaerschalk BM, Khatri P, McMullan PW, Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H, Council AHAS, Council on Cardiovascular Nursing, Council on Peripheral Vascular Disease, Council on Clinical Cardiology. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870–947.

    Article  PubMed  Google Scholar 

  27. Hornig CR, Dorndorf W, Agnoli AL. Hemorrhagic cerebral infarction—a prospective study. Stroke. 1986;17:179–85.

    Article  CAS  PubMed  Google Scholar 

  28. Geeganage C, Bath PMW (2008) Interventions for deliberately altering blood pressure in acute stroke. Cochrane Database Syst Rev. CD000039

    Google Scholar 

  29. Potter JF, Robinson TG, Ford GA, Mistri A, James M, Chernova J, Jagger C. Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial. Lancet Neurol. 2009;8:48–56.

    Article  CAS  PubMed  Google Scholar 

  30. Sandset EC, Bath PMW, Boysen G, Jatuzis D, Kõrv J, Lüders S, Murray GD, Richter PS, Roine RO, Terént A, Thijs V, Berge E, SCAST Study Group. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial. Lancet. 2011;377:741–50.

    Article  CAS  PubMed  Google Scholar 

  31. He J, Zhang Y, Xu T, Zhao Q, Wang D, Chen C-S, Tong W, Liu C, Xu T, Ju Z, Peng Y, Peng H, Li Q, Geng D, Zhang J, Li D, Zhang F, Guo L, Sun Y, Wang X, Cui Y, Li Y, Ma D, Yang G, Gao Y, Yuan X, Bazzano LA, Chen J. Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke. JAMA. 2014;311:479–89.

    Article  CAS  PubMed  Google Scholar 

  32. Robinson TG, Potter JF, Ford GA, Bulpitt CJ, Chernova J, Jagger C, James MA, Knight J, Markus HS, Mistri AK, Poulter NR, Investigators OBOTC. Effects of antihypertensive treatment after acute stroke in the Continue or Stop Post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomised, open, blinded-endpoint trial. Lancet Neurol. 2010;9:767–75.

    Article  CAS  PubMed  Google Scholar 

  33. Investigators TET. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet. 2015;385:617–28.

    Article  Google Scholar 

  34. Oh MS, Yu K-H, Hong K-S, Kang D-W, Park J-M, Bae H-J, Koo J, Lee J, Lee B-C. Valsartan efficacy oN modesT blood pressUre REduction in acute ischemic stroke (VENTURE) study group. Modest blood pressure reduction with valsartan in acute ischemic stroke: a prospective, randomized, open-label, blinded-end-point trial. Int J Stroke. 2015;10(5):745–51. doi:10.1111/ijs.12446.

    Article  PubMed  Google Scholar 

  35. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, Smith Jr SC, Svetkey LP, Taler SJ, Townsend RR, Wright Jr JT, Narva AS, Ortiz E. 2014 evidence-based guideline for the management of high blood pressure in adults. JAMA. 2014;311:507–14.

    Article  CAS  PubMed  Google Scholar 

  36. Levy DE, Brott TG, Haley EC, Marler JR, Sheppard GL, Barsan W, Broderick JP. Factors related to intracranial hematoma formation in patients receiving tissue-type plasminogen activator for acute ischemic stroke. Stroke. 1994;25:291–7.

    Article  CAS  PubMed  Google Scholar 

  37. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333:1581–87.

    Google Scholar 

  38. Wityk RJ, Lewin JJ. Blood pressure management during acute ischaemic stroke. Expert Opin Pharmacother. 2006;7:247–58.

    Article  PubMed  Google Scholar 

  39. Lopez-Yunez AM, Bruno A, Williams LS, Yilmaz E, Zurru C, Biller J. Protocol violations in community-based rTPA stroke treatment are associated with symptomatic intracerebral hemorrhage. Stroke. 2001;32:12–6.

    Article  CAS  PubMed  Google Scholar 

  40. Ahmed N, Wahlgren N, Brainin M, Castillo J, Ford GA, Kaste M, Lees KR, Toni D, Investigators SITS. Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR). Stroke. 2009;40:2442–9.

    Article  PubMed  Google Scholar 

  41. European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008;25:457–507.

    Article  Google Scholar 

  42. Authors/Task Force M, Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Scientific Council ESH, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, ESC Committee for Practice Guidelines (CPG), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Document R, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, De Buyzere M, De Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan JD, Kahan T, Komajda M, Lovic D, Mahrholdt H, Olsen MH, Ostergren J, Parati G, Perk J, Polonia J, Popescu BA, Reiner Z, Ryden L, Sirenko Y, Stanton A, Struijker-Boudier H, Tsioufis C, van de Borne P, Vlachopoulos C, Volpe M, Wood DA. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34:2159–219.

    Article  Google Scholar 

  43. Liu-DeRyke X, Janisse J, Coplin WM, Parker Jr D, Norris G, Rhoney DH. A comparison of nicardipine and labetalol for acute hypertension management following stroke. Neurocrit Care. 2008;9:167–76.

    Article  PubMed  Google Scholar 

  44. Liu-DeRyke X, Levy PD, Parker D, Coplin W, Rhoney DH. A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. Neurocrit Care. 2013;19:41–7.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to J. Dedrick Jordan M.D., Ph.D. .

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Jordan, J.D., Powers, W.J. (2016). Acute Blood Pressure Management After Ischemic Stroke. In: Aiyagari, V., Gorelick, P. (eds) Hypertension and Stroke. Clinical Hypertension and Vascular Diseases. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29152-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-29152-9_8

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