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The Effects of Hypertension and Stroke on the Cerebral Vasculature

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Hypertension and Stroke

Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

Abstract

Hypertension and stroke both have detrimental effects on the cerebral arteries. Stroke impairs myogenic tone generation and the regulation of blood flow. It also alters the structure of the cerebral arteries such that the lumen diameter of the ischemic artery increases after ischemia/reperfusion injury. Hypertension also causes artery remodeling but this results in a reduction in the lumen diameter of the arteries that could increase the risk of cerebral ischemia and the damage caused by it. Hypertension is a leading risk factor for stroke. Given the increasing interest in the vasculature as a therapeutic target for acute ischemic stroke, it would seem important that we develop a better understanding of the combined effects of hypertension and stroke on the cerebral arteries.

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  1. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA

    Anne M. Dorrance Ph.D.

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  1. Departments of Neurological Surgery and Neurology and Neurotherapeutics , University of Texas Southwestern Medical Center , Dallas, Texas, USA

    Venkatesh Aiyagari

  2. Michigan State University Department of Translational Science & Molecular Medicine, Mercy Health Hauenstein Neurosciences, Grand Rapids, Michigan, USA

    Philip B. Gorelick

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Dorrance, A.M. (2016). The Effects of Hypertension and Stroke on the Cerebral Vasculature. In: Aiyagari, V., Gorelick, P. (eds) Hypertension and Stroke. Clinical Hypertension and Vascular Diseases. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29152-9_5

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