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Hypertension and Stroke pp 285–300Cite as

Hypertension, Cerebral Small Vessel Disease, and Cognitive Function

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Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

Abstract

The relationship of cerebral small vessel disease, hypertension, and cognitive functioning is complex. Evidence to date suggests that WMH on MRI are not “benign” insignificant incidental findings. Just as they serve as markers for cerebrovascular disease and increased risk for stroke, the cumulative impact of WMH and poorly controlled hypertension raise the risk for cognitive deterioration, dementia, and mood and behavior disturbance due to frontal-subcortical disconnection. It is less clear, however, what later-life treatment can be used to preserve cognitive functioning or to prevent cognitive decline or behavioral change. Additional well-designed clinical trials of blood pressure lowering in those at risk of cognitive decline or dementia are needed to guide clinicians in the treatment of these patients.

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  1. Hauenstein Neuroscience Center, Mercy Health Saint Mary’s Health Care, 245 Cherry St. SE, Suite 104, Grand Rapids, MI, 49503, USA

    David L. Nyenhuis Ph.D.

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  1. Departments of Neurological Surgery and Neurology and Neurotherapeutics , University of Texas Southwestern Medical Center , Dallas, Texas, USA

    Venkatesh Aiyagari

  2. Michigan State University Department of Translational Science & Molecular Medicine, Mercy Health Hauenstein Neurosciences, Grand Rapids, Michigan, USA

    Philip B. Gorelick

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Nyenhuis, D.L. (2016). Hypertension, Cerebral Small Vessel Disease, and Cognitive Function. In: Aiyagari, V., Gorelick, P. (eds) Hypertension and Stroke. Clinical Hypertension and Vascular Diseases. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29152-9_16

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