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Grapes and Inflammation

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Grapes and Health

Abstract

Diet may play a role in the regulation of inflammation and inflammation-related pathologies. Inflammation is correlated with oxidative stress, and grape and grape phytochemicals can affect both inflammation and oxidative stress in cell, animal, and clinical models. The most effective constituents in grape are unknown, but grape, grape extracts, and grape phytochemicals can affect cell signaling, transcription, and translation related to inflammation. These effects are likely more impactful than any direct oxidative species scavenging effects of antioxidant phytochemicals in grape. As discussed here, in vivo preclinical and clinical studies demonstrate that intake of grape products can modify both the mechanisms and degree of local and systemic inflammation. Studies discussed here include grape effects upon inflammation in the organs of metabolism and elimination as well as those involved in obesity, type 2 diabetes, and cardiovascular diseases. This chapter will discuss some potential mechanisms of effect as well as future challenges and potential research directions for grapes and inflammation.

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Authors and Affiliations

  1. Cardioprotection Research Lab, Department of Cardiac Surgery, University of Michigan Health System, 2800 Plymouth Road, NCRC B26-241S, Ann Arbor, MI, 48109, USA

    E. Mitchell Seymour Ph.D. & Steven F. Bolling

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  1. E. Mitchell Seymour Ph.D.
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  2. Steven F. Bolling
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Correspondence to E. Mitchell Seymour Ph.D. .

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  1. A & M Schwartz Coll of Pharm & Health Sc, Long Island University, Hilo, Hawaii, USA

    John M. Pezzuto

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Seymour, E.M., Bolling, S.F. (2016). Grapes and Inflammation. In: Pezzuto, J. (eds) Grapes and Health. Springer, Cham. https://doi.org/10.1007/978-3-319-28995-3_5

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