Abstract
Novel optical biosensors in direct interaction with living cells open new avenues in the detection of given cell types, including pathogenic microorganisms, and in the measurement of cytotoxicity of given xenobiotics, such as biothreat agents, on suitably selected cell types or lines. Evanescent optical field based biosensors emerging for such applications are reviewed, covering surface plasmon and waveguide based formats, imaging setup, employing optical waveguides, and digital holographic microscopy. Commercial technologies, along with main pathogenic microorganisms (Bacillus anthracis, Escherichia coli, Listeria monocytogenes, Campylobacter jejuni, etc.) as analytes and cell lines (native tissue and tumor cells) as cytotoxicity effect subjects are highlighted.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Abbas A, Linman MJ, Cheng Q (2011) New trends in instrumental design for surface plasmon resonance-based biosensors. Biosens Bioelectron 26:1815–1824
Abdulhalim I, Zourob M, Lakhtakia A (2007) Overview of optical biosensing techniques. In: Marks RS, Cullen DC, Karube I, Lowe CR, Weetall HH (eds) Handbook of biosensors and biochips. Wiley, London, pp 1–34
Acharya G, Chang C-L, Savran C (2006) An optical biosensor for rapid and label-free detection of cells. J Am Chem Soc 128:3862–3863
Acharya G, Doorneweerd DD, Chang C-L, Henne WA, Low PS, Savran CA (2007) Label-free optical detection of anthrax-causing spores. J Am Chem Soc 129:732–733
Adányi N, Bori Z, Szendrő I, Erdélyi K, Wang X, Schröder HC, Müller WEG (2013) Bacterial sensors based on biosilica immobilization for label-free OWLS detection. New Biotechnol 30(5):493–499
Adányi N, Németh E, Halász A, Szendrő I, Váradi M (2006) Application of electrochemical optical waveguide lightmode spectroscopy (EC-OWLS) for studying the effect of different stress factors on lactic acid bacteria. Anal Chim Acta 573–574:41–47
Adányi N, Majer-Baranyi K, Székács A (2015) Evanescent field effect based nanobiosensors for agro-environmental and food safety. In: Grumezescu AM (ed) Nanotechnology in food industry. Springer, Berlin (in press)
Alm K, El-Schich Z, Falck Miniotis M, Gjörloff Wingren A, Janicke B, Oredsson S (2013) Cells and holograms—Holograms and digital holographic microscopy as a tool to study the morphology of living cells. In: Mihaylova E (ed) Holography—Basic Principles and Contemporary Applications. InTech, Rijeka, pp 335–351
Aref A, Horvath R, McColl J, Ramsden JJ (2010) Optical monitoring of stem cellsubstratum interactions. J Biomed Opt 14:010501
Aref A, Horvath R, Ramsden JJ (2010) Spreading kinetics for quantifying cell state during stem cell differentiation. J Biol Phys Chem 10:1–7
Bata-Vidács I, Adányi N, Beczner J, Farkas J, Székács A (2013) Nanotechnology and microbial food safety. In: Mendez-Vilas A (ed) Microbial pathogens and strategies for combating them: science, technology and education. Formatex, Zubaran, pp 155–159
Bellapadrona G, Tesler AB, Grunstein D, Hossain LH, Kikkeri R, Seeberger PH, Vaskevich A, Rubinstein I (2012) Optimization of localized surface plasmon resonance transducers for studying carbohydrate-protein interactions. Anal Chem 84:232–240
Bergoend I, Colomb T, Pavillon N, Emery Y, Depeursinge C (2009) Depth-of-field extension and 3D reconstruction in digital holographic microscopy. Proc SPIE 7390:73901C-1
Bishara W, Hongying Zhu H, Ozcan A (2010) Holographic opto-fluidic microscopy. Opt Express 18(26):27499
Bishara W, Sikora U, Mudanyali O, Su T-W, Yaglidere O, Luckhart S, Ozcan A (2011) Holographic pixel super-resolution in portable lensless on-chip microscopyusing a fiber-optic array. Lab Chip 11:1276–1279
Brecht A, Gauglitz G (1995) Optical probes and transducers. Biosens Bioelectron 10:923–936
Bremer C, Ntziachristos V, Weissleder R (2003) Optical-based molecular imaging: contrast agents and potential medical applications. Eur Radiol 13:231–243
Carl D, Kemper B, Wernicke G, Bally GV (2004) Parameter optimized digital holographic microscope for high resolution living cell analysis. Appl Opt 43:6536–6544
Chen S, Svedendahl M, Van Duyne RP, Käll M (2011) Plasmon-enhanced colorimetric ELISA with single molecule sensitivity. Nano Lett 11:1826–1830
Cheong W-F, Prahl SA, Welch AJ (1990) A review of the optical properties of biological tissues. IEEE J Quantum Elect 26:2166–2185
Choi M, Choi JW, Kim S, Nizamoglu S, Hahn SK, Yun SH (2013) Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo. Nat Photon 7:987–994
Citartan M, Gopinath SC, Tominaga J, Tang TH (2013) Label-free methods of reporting biomolecular interactions by optical biosensors. Analyst 138:3576–3592
Codex Alimentarius (2001) Principles and guidelines for the conduct of microbiological risk assessment. In: Food hygiene baic texts. Food and Agricultural Organizaton/World Health Organization, Rome
Colomb T, Pavillon N, Kühn J, Cuche E, Depeursinge C, Emery Y (2010) Extended depth-of-focus by digital holographic microscopy. Opt Lett 35(11):1840–1842
Comley J (2004) Label-free detection: New biosensors facilitate broader range of drug discovery applications. Drug Discov World Winter 2004(5):63–74
Conroy PJ, Hearty S, Leonard P, O’Kennedy RJ (2009) Antibody production, design and use for biosensor-based applications. Semin Cell Dev Biol 20:10–26
Cooper MA (2006) Optical biosensors: where next and how soon? Drug Discovery Today 11(23–24):1061–1067
Cooper MA (2009) Signal transduction profiling using label-free biosensors. J Recept Signal Transduction 29(3–4):224–233
Coskun AF, Cetin AE, Galarreta BC, Alvarez DA, Altug H, Ozcan A (2014) Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view. Sci Rep 4:6789
Cunningham B, Li P, Lin B, Pepper J (2002) Colorimetric resonant reflection as a direct biochemical assay technique. Sens Actuators B 81(2–3):316–328
D’Agata R, Grasso G, Iacono G, Spoto G, Vecchio G (2006) Lectin recognition of a new SOD mimic bioconjugate studied with surface plasmon resonance imaging. Org Biomol Chem 4:610–612
de Jong LAA, Uges DRA, Franke JP, Bischoff R (2005) Receptor-ligand binding assays: technologies and applications. J Chromatogr B 829:1–25
Duffus JH (1993) Glossary for chemists of terms used in toxicology. Pure Appl Chem 65:2003–2122
Endo T, Yamamura S, Tamiya E (2008) Label-free cell-based assay using localized surface plasmon resonance biosensor. Anal Chim Acta 614:182–189
Erdélyi K, Frutos AG, Ramsden JJ, Szendrő I, Voirin G (2008) Grating-based optical biosensors. In: Marks RS, Cullen DC, Karube I, Lowe CR Weetall HH (eds) Handbook of biosensors and biochips. Wiley, New York, pp 569–586
Commission European (2000) First Report on the Harmonisation of Risk Assessment Procedures (SSC 2000). European Commission, Brussels
Fan X, White IM, Shopova SI, Zhu H, Suter JD, Sun Y (2008) Sensitive optical biosensors for unlabeled targets: a review. Anal Chim Acta 620:8–26
Fang XY, Liu CL, Cheng XL, Wang YL, Yang YC (2011) A spectral imaging array biosensor and its application in detection of leukemia cell. Sens Actuat B-Chem 156:760–764
Fang Y (2006) Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Devel Technol 4(5):583–595
Fang Y (2007) Non-invasive optical biosensor for probing cell signaling. Sensors 7(10):2316–2329
Fang Y (2010) Label-free receptor assays. Drug Discov Today Technol 7(1):e5–e11
Fang Y (2010) Probing cancer signaling with resonant waveguide grating biosensors. Exp Opin Drug Discov 5(12):1237–1248
Fang Y (2010) Resonant waveguide grating biosensor for microarrays. In: Zourob M, Lakhtakia A (eds) Optical guided-wave chemical and biosensors II. Springer, Berlin, pp 27–42
Fang Y (2011) Label-free biosensors for cell biology. Int J Electrochem (2011: Article ID 460850, 16 p)
Fang Y (2013) Biosensors: On the origin of label-free cell phenotypic profiles of drug-target interactions. J Biochip Tissue Chip 3:e126
Fang Y (2013) Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery. J Pharmacol Toxicol Meth 67:69–81
Fang Y, Ferrie AM, Fontaine NH, Mauro J, Balakrishnan J (2006) Resonant waveguide grating biosensor for living cell sensing. Biophys J 91(5):1925–1940
Fang Y, Ferrie AM, Li G (2005) Probing cytoskeleton modulation by optical biosensors. FEBS Lett 579:4175–4180
Fang Y, Ferrie AM, Tran E (2009) Resonant waveguide grating biosensor for whole-cell GPCR assays. In: Leifert WR (ed) G Protein-coupled receptors in drug discovery. Methods in molecular biology 552 (pp 239–252). Humana Press, New York
Feng J, Siu VS, Pacifici D (2012) Nanoscale plasmonic interferometers for multispectral, high-throughput biochemical sensing. Nano Lett 12:602–609
Garcia D, Ghansah I, LeBlanc J, Butte MJ (2012) Counting cells with a low-cost integrated microfluidics-waveguide sensor. Biomicrofluidics 6:014115
Garcia-Sucerquia J, Xu W, Jericho S, Klages P, Jericho M, Kreuzer H (2006) Digital in-line holographic microscopy. Appl Optics 45(5):836–850
Ghosh N, Gupta G, Boopathi M, Pal V, Singh AK, Gopalan N, Goe AK (2013) Surface plasmon resonance biosensor for detection of Bacillus anthracis, the causative agent of anthrax from soil samples targeting protective antigen. Indian J Microbiol 53(1):48–55
Gnanaprakasa TJ, Oyarzabal OA, Olsen EV, Pedrosa VA, Simonian AL (2011) Tethered DNA scaffolds on optical sensor platforms for detection of hipo gene from Campylobacter jejuni. Sens Actuat B-Chem 156:304–311
Golosovsky M, Lirtsman V, Yashunsky V, Davidov D, Aroeti B (2009) Midinfrared surface-plasmon resonance: a novel biophysical tool for studying living cells. J Appl Phys 105:102036
Göröcs Z, Kiss M, Tóth V, Orzó L, Tőkés S (2010) Multicolor digital holographic microscope (DHM) for biological purposes. Proc SPIE 7568:75681P
Göröcs Z, McLeod E, Ozcan A (2015) Enhanced light collection in fluorescence microscopy using self-assembled micro-reflectors. Sci Rep 5:10999
Göröcs Z, Orzó L, Kiss M, Tóth V, Tőkés S (2010) In-line color digital holographic microscope for water quality measurements. Proc SPIE 7376:737614
Grandin HM, Städtler B, Textor M, Vörös J (2006) Waveguide excitation fluorescence microscopy: a new tool for sensing and imaging the biointerface. Biosens Bioelectron 21:1476–1482
Grasso G, D’Agata R, Zanoli L, Spoto G (2009) Microfluidic networks for surface plasmon resonance. Microchem J 93:82–86
Gustafsson M, Sebesta M (2004) Refractometry of microscopic objects with digital holography. Appl Opt 43:4796–4801
Haes AJ, Van Duyne RP (2004) A unified view of propagating and localized surface plasmon resonance biosensors. Anal Bioanal Chem 379:920–930
Hassanzadeh A, Armstrong S, Dixon SJ, Mittler S (2009) Multimode waveguide evanescent field fluorescence microscopy: Measurement of cell-substratum separation distance. Appl Phys Lett 94:033503
Hassanzadeh A, Azami D (2014) Waveguide evanescent field fluorescence microscopy: theoretical investigation of optical pressure on a cell. J Nanophoton 8:083076
Hassanzadeh A, Ma HK, Armstrong S, Dixon SJ, Sims SM, Mittler S (2009) Waveguide evanescent field fluorescence microscopy: from cell-substratum distances to kinetic cell behavior. Proc SPIE 2009:73220A
Hassanzadeh A, Ma HK, Dixon SJ, Mittler S (2012) Visualization of the solubilization process of the plasma membrane of a living cell by waveguide evanescent field fluorescence microscopy. J Biomed Opt 17(7):076025
Hassanzadeh A, Mittler S (2011) Waveguide evanescent field fluorescence microscopy: high contrast imaging of a domain forming mixed lipid Langmuir-Blodgett monolayer mimicking lung surfactant. J Biomed Opt 16(4):046022
Hassanzadeh A, Nitsche M, Armstrong S, Nabavi N, Harrison R, Dixon SJ, Langbein U, Mittler S (2010) Optical waveguides formed by silver ion exchange in Schott SG11 glass for waveguide evanescent field fluorescence microscopy: evanescent images of HEK293 cells. J Biomed Opt 15(3):036018
Hassanzadeh A, Nitsche M, Mittler S, Armstrong S, Dixon J, Langbein U (2008) Waveguide evanescent field fluorescence microscopy: Thin film fluorescence intensities and its application in cell biology. Appl Phys Lett 92:233503
Hessel A, Oliner AA (1965) A new theory of Wood’s anomalies on optical gratings. Appl Opt 4(10):1275–1297
Hilderbrand SA, Weissleder R (2010) Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol 14:71–79
Hong Y, Huh Y-M, Yoon DS, Yang J (2012) Nanobiosensors based on localized surface plasmon resonance for biomarker detection. J Nanomater (Article ID 759830, 13 p)
Horvath R, Cottier K, Pedersen HC, Ramsden JJ (2008) Multidepth screening of living cells using optical waveguides. Biosens Bioelectron 24(4):799–804
Horvath R, Lindvold LR, Larsen NB (2002) Reverse-symmetry waveguides: theory and fabrication. Appl Phys B 74:383–393
Horvath R, Pedersen HC, Skivesen N, Selmeczi D, Larsen NB (2003) Optical waveguide sensor for on-line monitoring of bacteria. Opt Lett 28:1233–1235
Horvath R, Pedersen HC, Skivesen N, Selmeczi D, Larsen NB (2005) Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing. Appl Phys Lett 86:071101
Horvath R, Pedersen HC, Skivesen N, Svanberg C, Larsen NB (2005) Fabrication of reverse symmetry polymer waveguide sensor chips on nanoporous substrates using dip-floating. J Micromech Microeng 15:1260–1264
Hu R, Yong K-T, Roy I, Ding H, He S, Prasad PN (2009) Metallic nanostructures as localized plasmon resonance enhanced scattering probes for multiplex dark-field targeted imaging of cancer cells. J Phys Chem C 113:2676–2684
Huang K-W, Su T-W, Ozcan A, Chiou P-Y (2013) Optoelectronic tweezers integrated with lensfree holographic microscopyfor wide-field interactive cell and particle manipulation on a chip. Lab Chip 13:2278–2284
Hug TS, Prenosil JE, Maier P, Morbidelli M (2002) Optical waveguide lightmode spectroscopy (OWLS) to monitor cell proliferation quantitatively. Biotechnol Bioeng 80:213–221
Hug TS, Prenosil JE, Morbidelli M (2001) Optical waveguide lightmode spectroscopy as a new method to study adhesion of anchorage-dependent cells as an indicator of metabolic state. Biosens Bioelectron 16:865–874
Isikman SO, Greenbaum A, Lee M, Bishara W, Mudanyali O, Su T-W, Ozcan A (2012) Lensfree computational microscopy tools for cell and tissue imaging at the point-of-care and in low-resource settings. Anal Cell Path 35:229–247
Isikman SO, Greenbaum A, Luo W, Coskun AF, Ozcan A (2012) Giga-pixel lensfree holographic microscopy and tomography using color image sensors. PLoS ONE 7(9):e45044
Joseph S, Gineste J-M, Whelan M, Newport D (2010) A heterodyne Mach-Zehnder Interferometer employing static and dynamic phase demodulation techniques for live-cell imaging. Proc SPIE 7554:75540P
Joung CK, Kim HN, Lim MC, Jeon TJ, Kim HY, Kim YR (2013) A nanoporous membrane based impedimetric immunosensor for label free detection of pathogenic bacteria in whole milk. Biosens Bioelectron 44:210–215
Kaul RA, Mahlmann DM, Loosen P (2010) Mach-Zehnder interference microscopy optically records electrically stimulated cellular activity in unstained nerve cells. J Microsc 240(1):60–74
Kemper B, Carl D, Schnekenburger J, Bredebusch I, Schäfer M, Domschke W, von Bally G (2006) Investigation of living pancreas tumor cells by digital holographic microscopy. J Biomed Optics 11(3):034005
Kiss M, Nagy B, Lakatos P, Göröcs Z, Tőkés S, Wittner B, Orzó L (2014) Special multicolor illumination and numerical tilt correction in volumetric digital holographic microscopy. Opt Express 22:7559–7573
Kozma P, Kehl F, Ehrentreich-Förster E, Stamm C, Bier FF (2014) Integrated planar optical waveguide interferometer biosensors: A comparative review. Biosens Bioelectron 58:287–307
Kramer MF, Tims TB, DeMarco DR, Lim DV (2002) Recovery of Escherichia coli 0157:H7 from fiber optic waveguides used for rapid biosensor detection. J Rapid Meth Autom Microbiol 10:93–106
Kühn J, Shaffer E, Mena J, Breton B, Parent J, Rappaz B, Chambon M, Emery Y, Magistretti P, Depeursinge C, Marquet P, Turcatti G (2013) Label-free cytotoxicity screening assay by digital holographic microscopy. Assay Drug Devel Technol 11(2):101–107
Lan Y, Wang S, Yin Y, Hoffmann WC (2008) Using a surface plasmon resonance biosensor for rapid detection of Salmonella typhimurium in chicken carcass. J Bionic Eng 5:239–246
Lechuga LM (2000) Optical sensors based on evanescent field sensing Part I. Surface plasmon resonance sensors. Quim Anal 19:54–60
Lechuga LM (2000) Optical sensors based on evanescent field sensing Part II. Integrated optical sensors. Quim Anal 19:61–67
Lee M, Yaglidere O, Ozcan A (2011) Field-portable reflection and transmission microscopy based on lensless holography. Biomed Opt Express 2(9):2721
Lee PH (2009) Label-free optical biosensor: a tool for G protein coupled receptors pharmacology profiling and inverse agonists identification. J Recept Sign Transduct 29(3–4):146–153
Leskinen SD, Lim DV (2008) Rapid ultrafiltration concentration and biosensor detection of enterococci from large volumes of Florida recreational water. Appl Environ Microbiol 74(15):4792–4798
Lin B, Li P, Cunningham BT (2006) A label-free biosensor-based cell attachment assay for characterization of cell surface molecules. Sens Actuat B-Chem 114:559–564
Liu F, Wong MM, Chiu SK, Lin H, Ho JC, Pang SW (2014) Effects of nanoparticle size and cell type on high sensitivity cell detection using a localized surface plasmon resonance biosensor. Biosens Bioelectron 55:141–148
Luo W, Greenbaum A, Zhang Y, Ozcan A (2015) Synthetic aperture-based on-chip microscopy. Sci Appl 4:e261
Mao X, Yang L, Su X, Li Y (2006) Nanoparticles amplification based quartz crystal microbalance DNA sensor for detection of E. coli O157:H7. Biosens Bioelectron 7:1178–1185
Marquet P, Rappaz B, Magistretti PJ, Cuche E, Emery Y, Colomb T, Depeursinge C (2005) Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with sub wavelength accuracy. Opt Lett 30:468–470
McLeod E, Ozcan A (2014) Nano-imaging enabled via self-assembly. Nano Today 9:560–573
Mo XT, Zhou YP, Lei H, Deng L (2002) Microbalance-DNA probe method for the detection of specific bacteria in water. Enzyme Microb Technol 5:583–589
Moskovits M (1985) Surface-enhanced spectroscopy. Rev Mod Phys 57:783–826
Mrksich M (2000) Model organic surfaces for mechanistic studies of cell adhesion. Chem Soc Rev 29(4):267–273
Mudanyali O, Bishara W, Ozcan A (2011) Lensfree super-resolution holographic microscopy using wetting films on a chip. Opt Express 19(18):17378
Mudanyali O, Tseng D, Oh C, Isikman SO, Sencan I, Bishara W, Oztoprak C, Seo S, Khademhosseini B, Ozcan A (2010) Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications. Lab Chip 10:1417–1428
Mukundan H, Anderson AS, Grace WK, Grace KM, Hartman N, Martinez JS, Swanson BI (2009) Waveguide-based biosensors for pathogen detection. Sensors 9:5783–5809
Németh E, Adányi N, Halász A, Váradi M, Szendrő I (2007) Real-time study of the effect of different stress factors on lactic acid bacteria by electrochemical optical waveguide lightmode spectroscopy. Biomol Eng 24:631–637
Nikolelis DP (ed) (2012) Portable biosensors: weapons against bioterrorism. NATO science for peace and security series a: chemistry and biology. Springer Verlag, Dordrecht
Nirschl M, Reuter F, Vörös J (2011) Review of transducer principles for label-free biomolecular interaction analysis. Biosensors 1:70–91
Oh B-R, Huang N-T, Chen W, Seo JH, Chen P, Cornell TT, Shanley TP, Fu J, Kurabayashi K (2014) Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood. ACS Nano 8(3):2667–2676
Oh C, Serhan SO, Khademhosseinieh B, Ozcan A (2010) On-chip differential interference contrast microscopy using lensless digital holography. Opt Express 18(5):4717
Orgovan N, Peter B, Sz Bősze, Ramsden JJ, Szabó B, Horvath R (2014) Dependence of cancer cell adhesion kinetics on integrin ligand surface density measured by a high-throughput label-free resonant waveguide grating biosensor. Sci Reports 4:4034
Orgovan N, Salánki R, Sándor N, Bajtay Z, Erdei A, Szabó B, Horvath R (2013) In-situ and label-free optical monitoring of the adhesion and spreading of primary monocytes isolated from human blood: dependence on serum concentration levels. Biosens Bioelectron 54:339–344
Orzó L, Göröcs Z, Fehér A, Tőkés S (2013) In-line hologram segmentation for volumetric samples. Appl Optics 52(1):A45–A55
Orzó L, Wittner B, Tőkés S (2013b) High speed water monitoring systems based on digital holographic microscopy. In: Computer Science and Information Technologies (CSIT), pp. 1–9
Ozcan A, Isikman S, Mudanyali O, Tseng D, Sencan I (2010) Lensfree on-chip holography facilitates novel microscopy applications. SPIE Newsroom, 2010 May 19:00294
Patko D, Cottier K, Hamori A, HorvatH R (2012) Single beam grating coupled interferometry: high resolution miniaturized label-free sensor for plate based parallel screening. Opt Express 20:23162
Patko D, Gyorgy B, Nemeth A, Szabó-Taylor KE, Kittel A, Buzas EI, Horvath R (2013) Label-free optical monitoring of surface adhesion of extracellular vesicles by grating coupled interferometry. Sens Actuat B-Chem 188:697–701
Patko D, Hamori A, Cottier K, Kurunczi S, Horvath R (2011) Label free biosensing using Grating Coupled Interferometry. Eur Biophys J with Biophys Lett 40:230–231
Peter B, Nador J, Juhasz K, Dobos A, Körösi L, Székács I, Patko D, Horvath R (2015) Incubator proof miniaturized Holomonitor to in situ monitor cancer cells exposed to green tea polyphenol and preosteoblast cells adhering on nanostructured titanate surfaces: validity of the measured parameters and their corrections. J Biomed Opt 20(6):067002. 10 p
Peters MF, Vaillancourt F, Heroux M, Valiquette M, Scott CW (2010) Comparing label-free biosensors for pharmacological screening with cell-based functional assays. ASSAY Drug Devel Technol 8(2):219–227
Rabus DG, Welle A, R. Seger A, Ichihashi Y, Bruendel M, Hieb J, Isaacson M (2006) Determination of living cell characteristics and behavior using biophotonic methods. Proc of SPIE 6329:63290H
Ramsden JJ, Horvath R (2009) Optical biosensors for cell adhesion. J Recept Sign Transduct Res 29:211–223
Ramsden JJ, Li SY, Heinzle E, Prenosil JE (1995) Optical method for measurement of number and shape of attached cells in real time. Cytom 19:97–102
Raphael MP, Christodoulides JA, Delehanty JB, Long JP, Pehrsson PE, Byers JM (2013) Quantitative LSPR imaging for biosensing with single nanostructure resolution. Biophys J 104:30–36
Rice JM, Stern LJ, Guignon EF, Lawrence DA, Lynes MA (2012) Antigen-specific T cell phenotyping microarrays using grating coupled surface plasmon resonance imaging and surface plasmon coupled emission. Biosens Bioelectron 31:264–269
Rich RL, Myszka DG (2006) Survey of the year 2005 commercial optical biosensor literature. J Mol Recogn 19(6):478–534
Rivet C, Lee H, Hirsch A, Hamilton S, Lu H (2011) Microfluidics for medical diagnostics and biosensors. Chem Eng Sci 66:1490–1507
Rizzo MA, Davidson MW, Piston DW (2010) Fluorescent protein tracking and detection. In: Goldman RD, Swedlow JR, Spector DL (eds) Live cell imaging: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, New York, pp 3–34
Rocheville M, Jerman JC (2009) 7TM pharmacology measured by label-free: a holistic approach to cell signaling. Curr Opinion Pharmacol 9(5):643–649
Sencan I, Coskun AF, Sikora U, Ozcan A (2014) Spectral demultiplexing in holographic and fluorescent on-chip microscopy. Sci Reports 4:3760
Seo S, Su T-W, Tseng DK, Erlinger A, Ozcan A (2009) Lensfree holographic imaging for on-chip cytometry and diagnostics. Lab Chip 9:777–787
Shamah SM, Cunningham BT (2011) Label-free cell-based assays using photonic crystal optical biosensors. Analyst 136:1090–102
Shiau AK, Massari ME, Ozbal CC (2008) Back to basics: label-free technologies for small molecule screening. Comb Chem High T Scr 11(3):231–237
Sim JH, Kwak YH, Choi CH, Paek S-H, Park SS, Seo S (2012) A birefringent waveguide biosensor platform for label-free live cell detection of Listeria monocytogenes. Sens Actuat B-Chem 173:752–759
Simonnet C, Groisman A (2005) Two-dimensional hydrodynamic focusing in a simple microfluidic device. Appl Phys Lett 87:114104
Simpson-Stroot JM, Kearns EA, Stroot PG, Magaña S, Lim DV (2008) Monitoring biosensor capture efficiencies: Development of a model using GFP-expressing Escherichia coli O157:H7. J Microbiol Meth 72:29–37
Singh V, Kumar D (2009) Theoretical modeling of a metal-clad planar waveguide based biosensor for the detection of pseudomonas-like bacteria. Progr Electromagn Res M 6:167–184
Spichiger-Keller UE (1998) Chemical sensors and biosensors for medical and biological applications. Wiley-VCH, Weinheim
Starodub NF, Ogorodniichuk YA, Sitnik YA, Slishik NF (2012) Biosensors for the control of some toxins, viral and microbial infections to prevent actions of bioterrorists. In: Nikolelis DP (ed) Portable chemical sensors. NATO science for peace and security series a: chemistry and biology. Springer, Dordrecht, pp 95–117
Stybayeva G, Mudanyali O, Seo S, Silangcruz J, Macal M, Ramanculov E, Dandekar S, Erlinger A, Ozcan A, Revzin A (2010) Lensfree holographic imaging of antibody microarrays for high-throughput detection of leukocyte numbers and function. Anal Chem 82(9):3736–3744
Su T, Ozcan A (2013) On-Chip holographic microscopy and its application for automated semen analysis. In: Shaked NT, Zalevsky Z, Satterwhite LL (eds) Biomedical optical phase microscopy and nanoscopy. Elsevier, Amsterdam, pp 153–171
Su T-W, Choi I, Feng J, Huang K, McLeod E, Ozcan A (2013) Sperm trajectories form chiral ribbons. Sci Rep 3:1664
Su T-W, Isikman SO, Bishara W, Tseng D, Erlinger A, Ozcan A (2010) Multi-angle lensless digital holography for depth resolved imaging on a chip. Opt Express 18(9):9690
Su TW, Xue L, Ozcan A (2012) High-throughput lensfree 3D tracking of human sperms reveals rare statistics of helical trajectories. Proc Natl Aacad Sci USA 109:16018–16022
Subramanian A (2006) A mixed self-assembled monolayer-based surface plasmon immunosensor for detection of E. coli O157H7. Biosens Bioelectron 7:998–1006
Sykes EA, Albanese A, Chan WCW (2013) Implantable waveguides. Nat Photon 7:940–941
Székács I, Fejes Á, Sz Klátyik, Takács E, Patkó D, Pomóthy J, Mörtl M, Horvath R, Madarász E, Darvas B, Székács A (2014) Environmental and toxicological impacts of glyphosate with its formulating adjuvant. Intl J Biol Food Vet Agric Food Engineer 8(3):213–218
Székács I, Pál I, Zs Környei, Szendrő I, Madarász E (2010) Initial cell attachment: events and kinetics of surface adhesion of NE-4C neural stem cells. Eur Cells Mater 20(3):252
Szendrő I, Erdélyi K, Puskás Z, Fábián M, Adányi N, Somogyi K (2012) Development and experiments with conductive oxide nanofilm coated planar waveguide sensors. Nanopages 7:17–24
Taitt CR, Anderson GP, Ligler FS (2005) Evanescent wave fluorescence biosensors. Biosens Bioelectron 20:2470–2487
Tan F, Leung PHM, Liud Z, Zhang Y, Xiao L, Ye W, Zhang X, Yi L, Yang M (2011) A PDMS microfluidic impedance immunosensor for E. coli O157:H7 and Staphylococcus aureus detection via antibody-immobilized nanoporous membrane. Sensor Actuat B-Chem 159:328–335
Teifenthaler K, Lukosz W (1989) Sensitivity of grating couplers as integrated-optical chemical sensors. J Opt Soc Am 6(2):209–220
Testa G, Persichettia G, Zenib L, Sarroc PM, Berninia R (2013) Optofluidics: a new tool for sensing. Proc SPIE 8794:879402
Thoma F, Langbein U, Mittler-Neher S (1997) Waveguide scattering microscopy. Opt Commun 134:16–20
Thuy NT, Tam PD, Tuan MA, Le AT, Tam LT, Thu VV, Hieu NV, Chien ND (2012) Detection of 32 pathogenic microorganisms using biosensor based on multi-walled carbon nanotubes dispersed in DNA solution. Curr Appl Phys 12:1553–1560
Tiefenthaler K, Lukosz W (1985) Grating couplers as integrated optical humidity and gas sensors. Thin Solid Films 126(3–4):205–211
Tims TB, Lim DV (2004) Rapid detection of Bacillus anthracis spores directly from powders with an evanescent wave fiber-optic biosensor. J Microbiol Methods 59(1):127–130
Tóth AE, Walter FR, Bocsik A, Sántha P, Veszelka S, Nagy L, Puskás LG, Couraud PO, Takata F, Dohgu S, Kataoka Y, Deli MA (2014) Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells. PLoS ONE 9(7):e100152
Tromberg BJ, Shah N, Lanning R, Cerussi A, Espinoza J, Pham T, Svaasand L, Butler J (2000) Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia 2:26–40
Tung Y-C, Huang N-T, Oh B-R, Patra B, Pan C-C, Qiu T, Chu PK, Zhang W, Kurabayashi K (2012) Optofluidic detection for cellular phenotyping. Lab Chip 12:3552–3565
Unser S, Bruzas I, He J, Sagle L (2015) Localized surface plasmon resonance biosensing: current challenges and approaches. Sensors 15:15684–15716
van Leeuwen CJ, Vermeire TG (eds) (2007) Risk assessment of chemicals. In: An introduction 2nd edn. Springer, Dordrecht
Vashist SK, Mudanyali O, Schneider EM, Zengerle R, Ozcan A (2014) Cellphone-based devices for bioanalytical sciences. Anal Bioanal Chem 406(14):3263–3277
Velasco-Garcia MN (2009) Optical biosensors for probing at the cellular level: A review of recent progress and future prospects. Semin Cell Develop Biol 20:27–33
Vörös J, Graf R, Kenausis GL, Bruinink A, Mayer J, Textor M, Wintermantel E, Spencer ND (2000) Feasibility study of an online toxicological sensor based on the optical waveguide technique. Biosens Bioelectron 15:423–429
Wan Y, Zhang D, Hou B (2009) Monitoring microbial populations of sulfate-reducing bacteria using an impedimetric immunosensor based on agglutination assay. Talanta 80:218–223
Wang DB, Bi LJ, Zhang ZP, Chen YY, Yang RF, Wei HP, Zhou YF, Zhang XE (2009) Label-free detection of B. anthracis spores using a surface plasmon resonance biosensor. Analyst 134(4):738–742
Wang J, Wu C, Hu N, Zhou J, Du L, Wang P (2012) Microfabricated electrochemical cell-based biosensors for analysis of living cells in vitro. Biosensors 2:127–170
Washa JW, Debroy C, Irudayaraj J (2006) Rapid detection of Salmonella enteritidis and Escherichia coli using surface plasmon resonance biosensor. J Food Process Eng 4:373–385
Wei D, Oyarzabal OA, Huang TS (2007) Development of a surface plasmon resonance biosensor for the identification of Campylobacter jejuni. J Microbiol Meth 69:78–85
Wei Q, McLeod E, Qi H, Wan Z, Sun R, Ozcan A (2013) On-chip cytometry using plasmonic nanoparticle enhanced lensfree holography. Sci Reports 3:1699
Wei Q, Qi H, Luo W, Tseng D, Ki SJ, Wan Z, Göröcs Z, Bentolila LA, Wu T-T, Sun R, Ozcan A (2013) Fluorescent imaging of single nanoparticles and viruses on a smart phone. ACS Nano 7(10):9147–9155
Willets KA, Van Duyne RP (2007) Localized surface plasmon resonance spectroscopy and sensing. Annu Rev Phys Chem 58:267–297
Wood RW (1902) Remarkable spectrum from a diffraction grating. Phil Mag 4(40):396–402
Wu M, Coblitz B, Shikano S, Long S, Spieker M, Frutos AG, Mukhopadhyay S, Li M (2006) Phospho-specific recognition by 14-3-3 proteins and antibodies monitored by a high throughput label-free optical biosensor. FEBS Lett 580(24):5681–5689
Xi F, Gao J, Wang J, Wang Z (2011) Discrimination and detection of bacteria with a label-free impedimetric biosensor based on self-assembled lectin monolayer. J Electroanal Chem 656:252–257
Yanase Y, Araki A, Suzuki A, Tsutsui T, Kimura T, Okamoto K, Nakatani T, Hiragun T, Hide M (2010) Development of an optical fiber SPR sensor for living cell activation. Biosens Bioelectron 25:1244–1247
Yashunsky V, Lirtsman V, Golosovsky M, Davidov D, Aroeti B (2010) Real-time monitoring of epithelial cell-cell and cell-substrate interactions by infrared surface plasmon spectroscopy. Biophys J 99:4028–4036
Yashunsky V, Lirtsman V, Zilbershtein A, Bein A, Schwartz B, Aroeti B, Golosovsky M, Davidov D (2012) Surface plasmon-based infrared spectroscopy for cell biosensing. J Biomed Optics 17(8):081409
Yashunsky V, Marciano T, Lirtsman V, Golosovsky M, Davidov D, Aroeti B (2012b) Real-time sensing of cell morphology by infrared waveguide spectroscopy. Plos ONE 7(10):e48454 10 p
Yetisen AK, Naydenova I, da Cruz Vasconcellos F, Blyth J, Lowe CR (2014) Holographic sensors: Three-dimensional analyte-sensitive nanostructures and their applications. Chem Rev 114:10654–10696
Zaytseva N, Miller W, Goral V, Hepburn J, Fang Y (2011) Microfluidic resonant waveguide grating biosensor system for whole cell sensing. Appl Phys Lett 98:163703
Zhao J, Zhang XY, Van Duyne RP (2006) Localized surface plasmon resonance biosensors. Nanomedicine 1:219–228
Zhao W, Lu J, Ma W, Xu C, Kuang H, Zhu S (2011) Rapid on-site detection of Acidovorax avenae subsp. citrulli by gold-labeled DNA strip sensor. Biosens Bioelectron 26:4241–4244
Zhao YJ, Zhao XW, Gu ZZ (2010) Photonic crystals in bioassays. Adv Funct Mater 20(18):2970–2988
Zhu P, Shelton DR, Karns JS, Sundaram A, Li S, Amstutz P, Tang C-M (2005) Detection of water-borne E. coli O157 using the integrating waveguide biosensor. Biosens Bioelectron 21:678–683
Zourob M, Elwary S, Turner A (eds) (2008) Principles of bacterial detection: biosensors, recognition receptors and microsystems. Springer Science+Business Media LLC, New York
Zourob M, Mohr S, Brown BJT, Fielden PR, McDonnell MB, Goddard NJ (2005) An integrated metal clad leaky waveguide sensor for detection of bacteria. Anal Chem 77:232–242
Madarasz E, Levkovets I, Erdelyi K, Szendro I (2007) Label free biosensor assay on the kinetics of cellsubstrate interactions. Eur. Cells. Mater. 14(Suppl 3):100
Acknowledgments
Research was funded by projects “Development of optical bio-sensors for detection of bio-toxins” (NUKR.SFPP 984637) in the NATO SPS Programme, “Mechanism-related teratogenic, hormone modulant and other toxicological effects of veterinary and agricultural surfactants” (OTKA K109865) by the Hungarian Research Fund, and by the Momentum Program (Lendület) of the Hungarian Academy of Sciences.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Székács, I., Horvath, R., Székács, A. (2016). Label-Free Optical Biosensors for Monitoring Cellular Processes and Cytotoxic Agents at Interfaces Using Guided Modes and Advanced Phase-Contrast Imaging Techniques. In: Nikolelis, D., Nikoleli, GP. (eds) Biosensors for Security and Bioterrorism Applications. Advanced Sciences and Technologies for Security Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-28926-7_21
Download citation
DOI: https://doi.org/10.1007/978-3-319-28926-7_21
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28924-3
Online ISBN: 978-3-319-28926-7
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)