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Managing Thoracic Tumors During Pregnancy

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Managing Cancer during Pregnancy

Abstract

Thoracic tumors during pregnancy is a rare coexistence. Only 66 cases of lung cancer have been published during the last two decades. Gestational thymomas and mesotheliomas are even more infrequent gestational tumors.

Among lung tumors, non-small lung cancer is the most common type. Almost all cases are presented with locally advanced or disseminated disease. Chemotherapy and/or targeted treatment exhibits poor therapeutic results, while overall survival is dismal with almost all patients dying in less than 12 months. Although newborn outcome is in most of the cases uneventful, gestational lung cancer shows high predilection in invading the products of conception (placenta and fetus).

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References

  1. Pentheroudakis G, Pavlidis N. Cancer and pregnancy: Poena magna, not anymore. Eur J Cancer. 2006;42(2):126–40.

    Article  PubMed  Google Scholar 

  2. Voulgaris E, Pentheroudakis G, Pavlidis N. Cancer and pregnancy: a comprehensive review. Surg Oncol. 2011;20(4):e175–85.

    Article  CAS  PubMed  Google Scholar 

  3. Pentheroudakis G, Pavlidis N. Gastrointestinal, urologic and lung malignancies during pregnancy. Recent results. Cancer Res. 2008;178:137–64.

    CAS  Google Scholar 

  4. Jemal A, Siegel R, Ward E, et al. Cancer statistics 2006. CA Cancer J Clin. 2006;56:106–30.

    Article  PubMed  Google Scholar 

  5. Boussios S, Han SN, Fuscio R, et al. Lung cancer in pregnancy: report of nine cases from an international collaborative study. Lung Cancer. 2013;82:499–505.

    Article  CAS  PubMed  Google Scholar 

  6. Azim Jr HA, Peccatori FA, Pavlidis N. Lung cancer in the pregnant woman: to treat or not to treat, that is the question. Lung Cancer. 2010;67:251–6.

    Article  PubMed  Google Scholar 

  7. Hayama M, Chida M, Tamura M, et al. Unexpected rapid growth of estrogen receptor positive lung cancer during pregnancy. Ann Thorac Cardiovasc Surg. 2014;20:325–8.

    Article  PubMed  Google Scholar 

  8. Sariman N, Levent E, Yener NA, et al. Lung cancer and pregnancy. Lung Cancer. 2013;79:321–3.

    Article  PubMed  Google Scholar 

  9. Cearisk M, Hostikc S, Sajin M, et al. Gestational lung adenocarcinoma: case report. Int J Surg Pathol. 2014;22(7):663–6.

    Article  Google Scholar 

  10. Kim JW, Kim JS, Cho JY, Lee DH. Successful video-assisted thorocoscopic lobectomy in a pregnant woman with lung cancer. Lung Cancer. 2014;85:331–4.

    Article  PubMed  Google Scholar 

  11. Neves I, Mota PC, Hespanhol VP. Lung cancer during pregnancy: an unusual case. Rev Port Pneumol. 2014;20(1):46–9.

    Article  CAS  PubMed  Google Scholar 

  12. Gil S, Goetgheluck J, Paci A, et al. Efficacy and safety of Gefitinib during pregnancy: case report and literature review. Lung Cancer. 2014;85:481–4.

    Article  CAS  PubMed  Google Scholar 

  13. Hechtman JF, Chepovetisky JA, Strauchen JA, et al. Thymomas diagnosed during pregnancies: two cases in young women without paraneoplastic or autoimmune disease. Ann Diagn Pathol. 2012;16(5):392–6.

    Article  PubMed  Google Scholar 

  14. McLaughlin SS, Peckham SJ, Enis JA, et al. Young woman with thymoma metastatic to the brain controlled with gross total resection and stereotactic radiosurgery, with a subsequent uncomplicated pregnancy. J Clin Oncol. 2011;29(2):e30–3.

    Article  PubMed  Google Scholar 

  15. Ramsey PS, Danilenko-Dixon DR, Ramin KD, Ogbwrn Jr PL. Malignant pleural mesothelioma in pregnancy. J Matern Fetal Med. 2000;9(6):373–5.

    Article  CAS  PubMed  Google Scholar 

  16. Wang A, Kubo J, Luo J, et al. Active and passive smoking in relation to lung cancer incidence in the Women’s Health Initiative Observational Study prospective cohort. Ann Oncol. 2015;26(1):221–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Lortet-Tieulent J, Soerjomataram I, Ferlay J, et al. International trends in lung cancer by histological type: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer. 2014;84(1):13–22.

    Article  CAS  PubMed  Google Scholar 

  18. Azim Jr HA, Peccatori FA, Pavlidis N. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: solid tumors. Cancer Treat Rev. 2010;36(2):101–9.

    Article  CAS  PubMed  Google Scholar 

  19. Azim Jr HA, Pavlidis N, PeccatorI FA. Treatment of the pregnant mother with cancer: a systematic review of the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part II: hematologic tumors. Cancer Treat Rev. 2010;36(2):110–21.

    Article  CAS  PubMed  Google Scholar 

  20. Amant F, Han SN, Gziri MM, et al. Chemotherapy during pregnancy. Curr Opin Oncol. 2012;24:580–6.

    Article  CAS  PubMed  Google Scholar 

  21. Lambertini M, Peccatori FA, Azim Jr HA. Targeted agents for cancer treatment during pregnancy. Cancer Treat Rev. 2015;41(4):301–9.

    Article  CAS  PubMed  Google Scholar 

  22. Pavlidis N, Petheroudakis G. Metastatic involvement of placenta and foetus in pregnant women with cancer. Recent Results Cancer Res. 2008;178:183–94.

    Article  CAS  PubMed  Google Scholar 

  23. Pavlidis N, Peccatori FA, Lofts F, Greco AF. Cancer of unknown primary during pregnancy: an exceptionally rare coexistence. Anticancer Res. 2011;35(1):575–9.

    Google Scholar 

  24. Jackisch C, Louwen F, Schwenkhagen A, et al. Lung cancer during pregnancy involving the products of conception and a review of the literature. Arch Gynecol Obstet. 2003;268:69–77.

    PubMed  Google Scholar 

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Correspondence to Nicholas Pavlidis MD, PhD, FRCP Edin (Hon) .

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© 2016 Springer International Publishing Switzerland

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Pavlidis, N., Zarkavelis, G. (2016). Managing Thoracic Tumors During Pregnancy. In: Azim Jr, H. (eds) Managing Cancer during Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-319-28800-0_16

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  • DOI: https://doi.org/10.1007/978-3-319-28800-0_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28798-0

  • Online ISBN: 978-3-319-28800-0

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