Emerging and Rare Viral Infections in Transplantation

  • Staci A. Fischer


Immunocompromised patients such as those undergoing solid organ or hematopoietic stem cell transplantation are at substantial risk for infection with numerous pathogens. Infections with cytomegalovirus (CMV), herpes simplex virus (HSV), Epstein–Barr virus (EBV), and human herpesvirus-6 (HHV-6) are well-described complications of transplantation. As viruses previously believed to be quiescent through widespread vaccination (e.g., measles and mumps) reemerge and molecular diagnostic techniques are refined, rare and emerging viral infections are increasingly diagnosed in transplant recipients. This chapter will review the clinical manifestations, diagnosis, and potential antiviral therapies for these viruses in the transplant population.


Bocavirus Coronavirus Hepatitis E Norovirus Parvovirus Metapneumovirus 


  1. 1.
    Palombo EA, Bishop RF. Annual incidence, serotype distribution, and genetic diversity of human astrovirus isolates from hospitalized children in Melbourne, Australia. J Clin Microbiol. 1996;34:1750–3.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Lewis DC, Lightfoot NF, Cubitt WD, Wilson SA. Outbreaks of astrovirus type 1 and rotavirus gastroenteritis in a geriatric in-patient population. J Hosp Infect. 1989;14:9–14.PubMedCrossRefGoogle Scholar
  3. 3.
    Lopes-Joao A, Costa I, Mesquita JR, et al. Multiple enteropathogenic viruses in a gastroenteritis outbreak in a military exercise of the Portuguese army. J Clin Virol. 2015;68:73–5.PubMedCrossRefGoogle Scholar
  4. 4.
    Naccache SN, Peggs KS, Mattes FM, et al. Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing. Clin Infect Dis. 2015;60:919–23.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Brown JR, Morfopoulou S, Hubb J, et al. Astrovirus VA1/HMO-C: an increasingly recognized neurotropic pathogen in immunocompromised patients. Clin Infect Dis. 2015;60:881–8.PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Kesebir D, Vazquez M, Weibel C, et al. Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J Infect Dis. 2006;194:1276–82.PubMedCrossRefGoogle Scholar
  7. 7.
    Cheung W-X, Jin Y, Duan Z-J, et al. Human bocavirus in children hospitalized for acute gastroenteritis: a case–control study. Clin Infect Dis. 2008;47:161–7.CrossRefGoogle Scholar
  8. 8.
    Campe H, Hartberger C, Sing A. Role of human bocavirus infections in outbreaks. J Clin Virol. 2008;43:340–2.PubMedCrossRefGoogle Scholar
  9. 9.
    Mitui MT, Bin Tabib SMS, Matsumoto T, et al. Detection of human bocavirus in the cerebrospinal fluid of children with encephalitis. Clin Infect Dis. 2012;54:964–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Manning A, Russell V, Eastick K, et al. Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses. J Infect Dis. 2006;194:1283–90.PubMedCrossRefGoogle Scholar
  11. 11.
    Schenk T, Strahm B, Kontny U, et al. Disseminated bocavirus infection after stem cell transplant. Emerg Infect Dis. 2007;13:1425–7.PubMedPubMedCentralCrossRefGoogle Scholar
  12. 12.
    Schenk T, Maier B, Hufnage M, et al. Persistence of human bocavirus DNA in immunocompromised children. Pediatr Infect Dis J. 2011;30:82–4.PubMedCrossRefGoogle Scholar
  13. 13.
    Miyakis S, van Hal SJ, Barratt J, et al. Absence of human Bocavirus in bronchoalveolar lavage fluid of lung transplant patients. J Clin Virol. 2009;44:179–80.PubMedCrossRefGoogle Scholar
  14. 14.
    Soccal PM, Aubert J-D, Bridevaux P-O, et al. Upper and lower respiratory tract viral infection and acute graft rejection in lung transplant recipients. Clin Infect Dis. 2010;51:163–70.PubMedCrossRefGoogle Scholar
  15. 15.
    Pialoux G, Gauzere B-A, Jaureguiberry S, Strobel M. Chikungunya, an epidemic arbovirus. Lancet Infect Dis. 2007;7:319–27.PubMedCrossRefGoogle Scholar
  16. 16.
    Weaver SC, Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med. 2015;372:1231–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Leparc-Goffart I, Nougairede A, Cassadou S, et al. Chikungunya in the Americas. Lancet. 2014;383:514.PubMedCrossRefGoogle Scholar
  18. 18.
    Couderc T, Gangneux N, Chretien F, et al. Chikungunya virus infection of corneal grafts. J Infect Dis. 2012;206:851–9.PubMedCrossRefGoogle Scholar
  19. 19.
    Centers for Disease Control and Prevention (CDC). Revised U.S. surveillance case definition for severe acute respiratory syndrome (SARS) and update on SARS cases—United States and worldwide, December 2003. MMWR Morb Mortal Wkly Rep. 2003;52:1202–6.Google Scholar
  20. 20.
    Leung GM, Hedley AJ, Ho LM, et al. The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients. Ann Intern Med. 2004;141:662–73.PubMedCrossRefGoogle Scholar
  21. 21.
    Vabret A, Dina J, Gouarin S, et al. Detection of the new human coronavirus HKU1: a report of 6 cases. Clin Infect Dis. 2006;42:634–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Tsang KW, Ho PL, Ooi GC, et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003;348:1977–85.PubMedCrossRefGoogle Scholar
  23. 23.
    Lee N, Hui D, Wu A, et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003;348:1986–94.PubMedCrossRefGoogle Scholar
  24. 24.
    Poutanen SM, Low DE, Henry B, et al. Identification of severe acute respiratory syndrome in Canada. N Engl J Med. 2003;348:1995–2005.PubMedCrossRefGoogle Scholar
  25. 25.
    Muller MP, Richardson SE, McGeer A, et al. Early diagnosis of SARS: lessons from the Toronto SARS outbreak. Eur J Clin Microbiol Infect Dis. 2006;25:230–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Roberts A, Thomas WD, Guarner J, et al. Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters. J Infect Dis. 2006;193:685–92.PubMedCrossRefGoogle Scholar
  27. 27.
    Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348:1967–76.PubMedCrossRefGoogle Scholar
  28. 28.
    Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–66.PubMedCrossRefGoogle Scholar
  29. 29.
    Booth TF, Kournikakis B, Bastien N, et al. Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. J Infect Dis. 2005;191:1472–7.PubMedCrossRefGoogle Scholar
  30. 30.
    Adachi D, Johnson G, Draker R, et al. Comprehensive detection and identification of human coronaviruses, including the SARS associated coronavirus, with a single RT-PCR assay. J Virol Methods. 2004;122:29–36.PubMedCrossRefGoogle Scholar
  31. 31.
    Kumar D, Tellier R, Draker R, et al. Severe acute respiratory syndrome (SARS) in a liver transplant recipient and guidelines for donor SARS screening. Am J Transplant. 2003;3:977–81.PubMedCrossRefGoogle Scholar
  32. 32.
    Farcas GA, Poutanen SM, Mazzulli T, et al. Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus. J Infect Dis. 2005;191:193–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Xu J, Zhing S, Liu J, et al. Detection of severe acute respiratory syndrome coronavirus in the rain: potential role of the chemokine Mig in pathogenesis. Clin Infect Dis. 2005;41:1089–96.PubMedCrossRefGoogle Scholar
  34. 34.
    Svoboda T, Henry B, Shulman L, et al. Public health measures to control the spread of the severe acute respiratory syndrome during the outbreak in Toronto. N Engl J Med. 2004;350:2352–61.PubMedCrossRefGoogle Scholar
  35. 35.
    Gautret P, Gray GC, Charrel RN, et al. Emerging viral respiratory tract infections – environmental risk factors and transmission. Lancet Infect Dis. 2014;14:1113–22.PubMedCrossRefGoogle Scholar
  36. 36.
    Drosten C, Seilmaier M, Corman VM, et al. Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet. 2013;13:745–51.PubMedCrossRefGoogle Scholar
  37. 37.
    Rasmussen SA, Gerber SI, Swerdlow DL. Middle East Respiratory Syndrome Coronavirus: update for clinicians. Clin Infect Dis. 2015;60(11):1686–9.PubMedPubMedCentralCrossRefGoogle Scholar
  38. 38.
    Arabi YM, Arifi AA, Balkhy HH, et al. Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection. Ann Intern Med. 2014;160:389–97.PubMedCrossRefGoogle Scholar
  39. 39.
    Memish ZA, Zumla AI, Assiri A. Middle East respiratory syndrome coronavirus infections in health care workers. N Engl J Med. 2013;369:884–6.PubMedCrossRefGoogle Scholar
  40. 40.
    Al-Abdallat MM, Payne DC, Alqasrawi S, et al. Hospital associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis. 2014;59:1225–33.PubMedPubMedCentralCrossRefGoogle Scholar
  41. 41.
    Memish ZA, Cotton M, Meyer B, et al. Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerg Infect Dis. 2014;20(6):1012–5.PubMedPubMedCentralCrossRefGoogle Scholar
  42. 42.
    AlGhamdi M, Mushtaq F, Awn N, Shalhoub S. MERS CoV infection in two renal transplant recipients: case report. Am J Transplant. 2015;15:1101–4.PubMedCrossRefGoogle Scholar
  43. 43.
    Chan JFW, Chan K-H, Kao RYT, et al. Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus. J Infect. 2013;67:606–16.PubMedCrossRefGoogle Scholar
  44. 44.
    Falzarano D, de Wit E, Rasmussen AL, et al. Treatment with interferon –alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med. 2013;19:1313–7.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Omrani AS, Saad MM, Baig K, et al. Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study. Lancet Infect Dis. 2014;14:1090–5.PubMedCrossRefGoogle Scholar
  46. 46.
    Garbino J, Crespo S, Aubert JD, et al. A prospective hospital based study of the clinical impact of non-severe acute respiratory syndrome (non-SARS)-related human coronavirus infection. Clin Infect Dis. 2006;43:1009–15.PubMedCrossRefGoogle Scholar
  47. 47.
    Pene F, Merlat A, Vabret A. Coronavirus 229E-related pneumonia in immunocompromised patients. Clin Infect Dis. 2003;37:929–32.PubMedCrossRefGoogle Scholar
  48. 48.
    Dalton HR, Bendall R, Ijaz S, Banks M. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis. 2008;8:698–709.PubMedCrossRefGoogle Scholar
  49. 49.
    Banks M, Heath GS, Grierson SS, et al. Evidence for the presence of hepatitis E virus in pigs in the United Kingdom. Vet Rec. 2004;154:223–7.PubMedCrossRefGoogle Scholar
  50. 50.
    Wang YC, Zhang HY, Xia NS, et al. Prevalence, isolation and partial sequence analysis of hepatitis E virus from domestic animals in China. J Med Virol. 2002;67:516–21.PubMedCrossRefGoogle Scholar
  51. 51.
    Mansuy JM, Legrand-Abravanel F, Calot JP, et al. High prevalence of anti-hepatitis E virus antibodies in blood donors from south west France. J Med Virol. 2008;80:289–93.PubMedCrossRefGoogle Scholar
  52. 52.
    Thomas DL, Yarbough PO, Vlahov D, et al. Seroreactivity to hepatitis E virus in areas where the disease is not endemic. J Clin Microbiol. 1997;35:1244–7.PubMedPubMedCentralGoogle Scholar
  53. 53.
    Matsuda H, Okada K, Takahashi K, Mishiro S. Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar. J Infect Dis. 2003;188:944.PubMedCrossRefGoogle Scholar
  54. 54.
    Tei S, Kitajima N, Takahashi K, Mishiro S. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet. 2003;362:371–3.PubMedCrossRefGoogle Scholar
  55. 55.
    Feagins AR, Opriessnig T, Guenette DK, et al. Detection and characterization of infectious hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. J Gen Virol. 2007;88:912–7.PubMedCrossRefGoogle Scholar
  56. 56.
    Mitsui T, Tsukamoto Y, Yamazaki C, et al. Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. J Med Virol. 2004;74:563–72.PubMedCrossRefGoogle Scholar
  57. 57.
    Boxall E, Herborn A, Kochethu G, et al. Transfusion-transmitted hepatitis E in a “nonhyperendemic” country. Transfus Med. 2006;16:79–83.PubMedCrossRefGoogle Scholar
  58. 58.
    Khuroo MS, Kamili S, Yattoo GN. Hepatitis E infection may be transmitted through blood transfusions in an endemic area. J Gastroenterol Hepatol. 2004;19:778–84.PubMedCrossRefGoogle Scholar
  59. 59.
    Matsubayashi K, Nagaoka Y, Sakata H, et al. Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion. 2004;44:934–40.PubMedCrossRefGoogle Scholar
  60. 60.
    Clayson ET, Myint KS, Snitbhan R, et al. Viremia, fecal shedding and IgM and IgG responses in patients with hepatitis E. J Infect Dis. 1995;172:927–33.PubMedCrossRefGoogle Scholar
  61. 61.
    Khuroo MS, Kamili S. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. J Viral Hepat. 2003;10:61–9.PubMedCrossRefGoogle Scholar
  62. 62.
    Bhatia V, Singhal A, Panda SK, Acharya SK. A 20-year single center experience with acute liver failure during pregnancy: is the prognosis really worse? Hepatology. 2008;48:1577–85.PubMedCrossRefGoogle Scholar
  63. 63.
    Halac U, Beland K, Lapierre P, et al. Chronic hepatitis E in children with liver transplantation. Gut. 2012;61:597–603.PubMedCrossRefGoogle Scholar
  64. 64.
    Legrand-Abravanel F, Kamar N, Sandres-Saune K, et al. Hepatitis E virus infection without reactivation in solid organ transplant recipients, France. Emerg Infect Dis. 2011;17:30–7.PubMedPubMedCentralCrossRefGoogle Scholar
  65. 65.
    Kamar N, Selves J, Mansuy J-M, et al. Hepatitis E virus and chronic hepatitis in solid organ transplant recipients. N Engl J Med. 2008;358:811–7.PubMedCrossRefGoogle Scholar
  66. 66.
    leCoutre P, Meisel H, Hoffman J, et al. Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukemia after allogeneic stem cell transplantation. Gut. 2009;58:699–702.CrossRefGoogle Scholar
  67. 67.
    Haagsma EB, Niesters HGM, van den Berg AP, et al. Prevalence of hepatitis E virus infection in liver transplant recipients. Liver Transpl. 2009;15:1225–8.PubMedCrossRefGoogle Scholar
  68. 68.
    Versluis J, Pas SD, Agteresch HJ, et al. Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation. Blood. 2013;122:1079–86.PubMedCrossRefGoogle Scholar
  69. 69.
    Kamar N, Weclawiak H, Guilbeau-Frugier C, et al. Hepatitis E virus and the kidney in solid organ transplant patients. Transplantation. 2012;93:617–23.PubMedGoogle Scholar
  70. 70.
    Pischke S, Suneetha PV, Baechlein C, et al. Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients. Liver Transpl. 2010;16:74–82.PubMedCrossRefGoogle Scholar
  71. 71.
    Kamar N, Izopet J, Cintas P, et al. Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis. Am J Transplant. 2010;10:1321–4.PubMedCrossRefGoogle Scholar
  72. 72.
    Kamar N, Rostaing L, Abravanel F, et al. Pegylated interferon-alpha for treating chronic hepatitis E virus infection after liver transplantation. Clin Infect Dis. 2010;50:e30–3.PubMedCrossRefGoogle Scholar
  73. 73.
    Kamar N, Rostaing L, Abravanel F, et al. Ribavirin therapy inhibits viral replication on patients with chronic hepatitis E virus infection. Gastroenterology. 2010;139:1612–8.PubMedCrossRefGoogle Scholar
  74. 74.
    Fischer SA, Graham MB, Kuehnert MJ, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med. 2006;354:2235–49.PubMedCrossRefGoogle Scholar
  75. 75.
    Centers for Disease Control and Prevention (CDC). Lymphocytic choriomeningitis virus infection in organ transplant recipients – Massachusetts, Rhode Island, 2005. MMWR Morb Mortal Wkly Rep. 2005;54:537–9.Google Scholar
  76. 76.
    Paddock C, Ksiazek T, Comer JA, et al. Pathology of fatal lymphocytic choriomeningitis virus infection in multiple organ transplant recipients from a common donor. Mod Pathol. 2005;18 Suppl 1:263A.Google Scholar
  77. 77.
    Palacios G, Druce J, Du L, et al. A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med. 2008;358:991–8.PubMedCrossRefGoogle Scholar
  78. 78.
    Simmonds P. A new arenavirus in transplantation. N Engl J Med. 2008;358:2638–9.PubMedCrossRefGoogle Scholar
  79. 79.
    Gregg MB. Recent outbreaks of lymphocytic choriomeningitis in the United States of America. Bull World Health Organ. 1975;52:549–53.PubMedGoogle Scholar
  80. 80.
    MacNeil A, Stoher U, Farnon E, et al. Solid organ transplant-associated lymphocytic choriomeningitis virus, United States, 2011. Emerg Infect Dis. 2012;18:1256–62.PubMedPubMedCentralCrossRefGoogle Scholar
  81. 81.
    Hirsch MS, Moellering Jr RC, Pope HG, et al. Lymphocytic choriomeningitis virus infection traced to a pet hamster. N Engl J Med. 1974;291:610–2.PubMedCrossRefGoogle Scholar
  82. 82.
    Skinner HH, Knight EH. The potential role of Syrian hamsters and other small animals as reservoirs of lymphocytic choriomeningitis virus. J Small Anim Pract. 1979;20:145–61.PubMedCrossRefGoogle Scholar
  83. 83.
    Childs JE, Glass GE, Ksiazek TG, et al. Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner city population. Am J Trop Med Hyg. 1991;44:117–21.PubMedCrossRefGoogle Scholar
  84. 84.
    Amman BR, Pavlin BI, Albarino CG, et al. Pet rodents and fatal lymphocytic choriomeningitis in transplant patients. Emerg Infect Dis. 2007;13:719–25.PubMedPubMedCentralCrossRefGoogle Scholar
  85. 85.
    Warkel RL, Rinaldi CF, Bancroft WH, et al. Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. Neurology. 1973;23:198–203.PubMedCrossRefGoogle Scholar
  86. 86.
    Dare R, Sanghavi S, Bullotta A, et al. Diagnosis of human metapneumovirus infection in immunocompromised lung transplant recipients and children evaluated for pertussis. J Clin Microbiol. 2007;45:548–52.PubMedCrossRefGoogle Scholar
  87. 87.
    Esper F, Boucher D, Weibel C, et al. Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging respiratory infection in children. Pediatrics. 2003;111:1407–10.PubMedCrossRefGoogle Scholar
  88. 88.
    Bastien N, Ward D, Van Caeseele P, et al. Human metapneumovirus infection in the Canadian population. J Clin Microbiol. 2003;41:4642–6.PubMedPubMedCentralCrossRefGoogle Scholar
  89. 89.
    Esper F, Martinello RA, Boucher D, et al. A 1-year experience with human metapneumovirus in children aged <5 years. J Infect Dis. 2004;189:1388–96.PubMedCrossRefGoogle Scholar
  90. 90.
    Boivin G, De Serres G, Hamelin ME, et al. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clin Infect Dis. 2007;44:1152–8.PubMedCrossRefGoogle Scholar
  91. 91.
    Sumino KC, Agapov E, Pierce RA, et al. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. J Infect Dis. 2005;192:1052–60.PubMedCrossRefGoogle Scholar
  92. 92.
    Larcher C, Geltner C, Fischer H, et al. Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology. J Heart Lung Transplant. 2005;24:1891–901.PubMedCrossRefGoogle Scholar
  93. 93.
    Dosanjh A. Respiratory metapneumovirus infection without co-infection in association with acute and chronic lung allograft dysfunction. J Inflamm Res. 2015;8:79–82.PubMedPubMedCentralCrossRefGoogle Scholar
  94. 94.
    Richards A, Chuen JN, Taylor C, et al. Acute respiratory infection in a renal transplant recipient. Nephrol Dial Transplant. 2005;20:2848–50.PubMedCrossRefGoogle Scholar
  95. 95.
    Englund JA, Boeckh M, Kuypers J, et al. Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients. Ann Intern Med. 2006;144:344–9.PubMedCrossRefGoogle Scholar
  96. 96.
    Debiaggi M, Canducci F, Sampaolo M, et al. Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients. J Infect Dis. 2006;194:474–8.PubMedCrossRefGoogle Scholar
  97. 97.
    Gerna G, Vitulo P, Rovida F, et al. Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients. J Med Virol. 2006;78:408–16.PubMedCrossRefGoogle Scholar
  98. 98.
    Hamlin ME, Prince GA, Boivin G. Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Antimicrob Agents Chemother. 2006;50:774–7.CrossRefGoogle Scholar
  99. 99.
    Raza K, Ismailjee SB, Crespo M, et al. Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin. J Heart Lung Transplant. 2007;26:862–4.PubMedCrossRefGoogle Scholar
  100. 100.
    Centers for Disease Control and Prevention (CDC). Import associated measles outbreak-Indiana, May–June 2005. MMWR Morb Mortal Wkly Rep. 2005;54:1073–75.Google Scholar
  101. 101.
    Centers for Disease Control and Prevention (CDC). Measles among adults associated with adoption of children in China—California, Missouri, and Washington, July–August 2006. MMWR Morb Mortal Wkly Rep. 2007;56:144–6.Google Scholar
  102. 102.
    Centers for Disease Control and Prevention (CDC). Multistate measles outbreak associated with an international youth sporting event—Pennsylvania, Michigan and Texas, August–September 2007. MMWR Morb Mortal Wkly Rep. 2008;57:169–73.Google Scholar
  103. 103.
    Centers for Disease Control and Prevention (CDC). Outbreak of measles – San Diego, California, January–February 2008. MMWR Morb Mortal Wkly Rep. 2008;57:203–6.Google Scholar
  104. 104.
    Centers for Disease Control and Prevention (CDC). Measles—United States, January 1–April 25, 2008. MMWR Morb Mortal Wkly Rep. 2008;57:1–4.Google Scholar
  105. 105.
    Kennedy AM, Gust DA. Measles outbreak associated with a church congregation: a study of immunization attitudes of congregation members. Public Health Rep. 2008;123:126–34.PubMedPubMedCentralCrossRefGoogle Scholar
  106. 106.
    Sugarman DE, Barskey AE, Delea MG, et al. Measles outbreak in a highly vaccinated population, San Diego, 2008: role of the intentionally undervaccinated. Pediatrics. 2010;125:747–55.CrossRefGoogle Scholar
  107. 107.
    Centers for Disease Control and Prevention (CDC). Notes from the field: measles outbreak among members of a religious community – Brooklyn, New York, March – June 2013. MMWR Morb Mortal Wkly Rep. 2013;62:752–3.Google Scholar
  108. 108.
    Zipprich J, Winter K, Hacker J, et al. Measles outbreak-California, December 2014-February 2015. MMWR Morb Mortal Wkly Rep. 2015;64:153–4.PubMedPubMedCentralGoogle Scholar
  109. 109.
    Wong RD, Goetz MB. Clinical and laboratory features of measles in hospitalized adults. Am J Med. 1993;95:377–83.PubMedCrossRefGoogle Scholar
  110. 110.
    Peltola H, Kulkarni PS, Kapre SV, et al. Mumps outbreak in Canada and the United States: time for new thinking on mumps vaccines. Clin Infect Dis. 2007;45:459–66.PubMedCrossRefGoogle Scholar
  111. 111.
    Centers for Disease Control and Prevention (CDC). Update: multistate outbreak of mumps-United States, January 1–May 2, 2006. MMWR Morb Mortal Wkly Rep. 2006;55:1.Google Scholar
  112. 112.
    Centers for Disease Control and Prevention (CDC). Update: multistate outbreak of mumps-United States, January 1–May 2, 2006. MMWR Morb Mortal Wkly Rep. 2006;55:559.Google Scholar
  113. 113.
    Centers for Disease Control and Prevention (CDC). Update: mumps activity—United States, January 1–October 7, 2006. MMWR Morb Mortal Wkly Rep. 2006;55:1152.Google Scholar
  114. 114.
    Dayan GH, Quinlisk P, Parker AA, et al. Recent resurgence of mumps in the United States. N Engl J Med. 2008;358:1580–9.PubMedCrossRefGoogle Scholar
  115. 115.
    Park DW, Nam M-H, Kim JY, et al. Mumps outbreak in a highly vaccinated school population: assessment of secondary vaccine failure using IgG avidity measurements. Vaccine. 2007;25:4665–70.PubMedCrossRefGoogle Scholar
  116. 116.
    Reid F, Hassan J, Irwin F, et al. Epidemiologic and diagnostic evaluation of a recent mumps outbreak using oral fluid samples. J Clin Virol. 2008;41:134–7.PubMedCrossRefGoogle Scholar
  117. 117.
    Shanley JD. The resurgence of mumps in young adults and adolescents. Cleve Clin J Med. 2007;74(42–44):47–8.Google Scholar
  118. 118.
    Bitsko RH, Cortese MM, Dayan GH, et al. Detection of RNA of mumps virus during an outbreak in a population with a high level of measles, mumps, and rubella vaccine coverage. J Clin Microbiol. 2008;46:1101–3.PubMedPubMedCentralCrossRefGoogle Scholar
  119. 119.
    Jin L, Feng Y, Parry R, et al. Real-time PCR and its application to mumps rapid diagnosis. J Med Virol. 2007;79:1761–7.PubMedCrossRefGoogle Scholar
  120. 120.
    Patel SR, Ortin M, Cohen BJ, et al. Revaccination with measles, tetanus, poliovirus, Haemophilus influenzae b, meningococcus C, and pneumococcus vaccines in children after hematopoietic stem cell transplantation. Clin Infect Dis. 2007;44:625–34.PubMedCrossRefGoogle Scholar
  121. 121.
    Centers for Disease Control and Prevention (CDC). Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of CDC, the Infectious Diseases Society of America, and the American Society of Blood and Marrow Transplantation. MMWR Morb Mortal Wkly Rep. 2000;49(RR10):1–125.Google Scholar
  122. 122.
    Centers for Disease Control and Prevention (CDC). Updated norovirus outbreak management and disease prevention guidelines. MMWR Morb Mort Wkly Rep. 2011;60(RR03):1–15.Google Scholar
  123. 123.
    Mead PS, Slutsker L, Dietz V, et al. Food-related illness and death in the United States. Emerg Infect Dis. 1999;5:607–25.PubMedPubMedCentralCrossRefGoogle Scholar
  124. 124.
    Marshall JA, Hellard ME, Sinclair MI, et al. Incidence and characteristics of endemic Norwalk-like virus-associated gastroenteritis. J Med Virol. 2003;69:568–78.PubMedCrossRefGoogle Scholar
  125. 125.
    Lopman BA, Adak GK, Reacher MH, et al. Two epidemiologic patterns of norovirus outbreaks: surveillance in England and Wales, 1992–2000. Emerg Infect Dis. 2003;9:71–7.PubMedPubMedCentralCrossRefGoogle Scholar
  126. 126.
    Tu ET-V, Bull RA, Kim M-J, et al. Norovirus excretion in an aged-care setting. J Clin Microbiol. 2008;46:2119–21.PubMedPubMedCentralCrossRefGoogle Scholar
  127. 127.
    Makary P, Maunula L, Niskanen T, et al. Multiple norovirus outbreaks among workplace canteen users in Finland, July 2006. Epidemiol Infect. 2009;137:402–7.PubMedCrossRefGoogle Scholar
  128. 128.
    Chen S-Y, Tsai C-N, Lai M-W, et al. Norovirus infection as a cause of diarrhea-associated benign infantile seizures. Clin Infect Dis. 2009;48:849–55.PubMedCrossRefGoogle Scholar
  129. 129.
    Patel MM, Hall AJ, Vinje J, et al. Noroviruses: a comprehensive review. J Clin Virol. 2009;44:1–8.PubMedCrossRefGoogle Scholar
  130. 130.
    Berg DE, Kohn MA, Farley TA, et al. Multistate outbreaks of acute gastroenteritis traced to fecal-contaminated oysters harvested in Louisiana. J Infect Dis. 2000;181 Suppl 2:S381–6.PubMedCrossRefGoogle Scholar
  131. 131.
    Anderson AD, Garrett VD, Sobel J, et al. Multistate outbreak of Norwalk-like virus gastroenteritis associated with a common caterer. Am J Epidemiol. 2001;154:1013–9.PubMedCrossRefGoogle Scholar
  132. 132.
    Centers for Disease Control and Prevention. Norwalk-like virus associated gastroenteritis in a large, high-density encampment—Virginia, July 2001. JAMA. 2001;288:1711–3.Google Scholar
  133. 133.
    Becker KM, Moe CL, Southwick KL, et al. Transmission of Norwalk virus during a football game. N Engl J Med. 2000;343:1223–7.PubMedCrossRefGoogle Scholar
  134. 134.
    Kuritsky JN, Osterholm MT, Greenberg HB, et al. Norwalk gastroenteritis: a community outbreak associated with bakery product consumption. Ann Intern Med. 1984;100:519–21.PubMedCrossRefGoogle Scholar
  135. 135.
    Long SM, Adak GK, O’Brien SJ, et al. General outbreaks of infectious intestinal disease linked with salad vegetables and fruit, England and Wales, 1992–2000. Commun Dis Public Health. 2002;5:101–5.PubMedGoogle Scholar
  136. 136.
    Lawson HW, Braun MM, Glass RI, et al. Waterborne outbreak of Norwalk virus gastroenteritis at a southwest US resort: role of geological formations in contamination of well water. Lancet. 1991;337:1200–4.PubMedCrossRefGoogle Scholar
  137. 137.
    Baron RC, Murphy FD, Greenberg HB, et al. Norwalk gastrointestinal illness: an outbreak associated with swimming in a recreational lake and secondary person-to-person transmission. Am J Epidemiol. 1982;115:163–72.PubMedCrossRefGoogle Scholar
  138. 138.
    Gotz H, Ekdahl K, Lindback J, et al. Clinical spectrum and transmission characteristics of infection with Norwalk-like virus: findings from a large community outbreak in Sweden. Clin Infect Dis. 2001;33:622–8.PubMedCrossRefGoogle Scholar
  139. 139.
    Hewitt J, Bell D, Simmons GC, et al. Gastroenteritis outbreak caused by waterborne norovirus at a New Zealand ski resort. Appl Environ Microbiol. 2007;73:7853–7.PubMedPubMedCentralCrossRefGoogle Scholar
  140. 140.
    Green KY, Belliot G, Taylor JL, et al. A predominant role for Norwalk-like viruses as agents of epidemic gastroenteritis in Maryland nursing homes for the elderly. Clin Infect Dis. 2001;33:622–8.CrossRefGoogle Scholar
  141. 141.
    Ahmad K. Norwalk-like virus attacks troops in Afghanistan. Lancet Infect Dis. 2002;2:391.PubMedCrossRefGoogle Scholar
  142. 142.
    Mattner F, Sohr D, Heim A, et al. Risk groups for clinical complications of norovirus infections: an outbreak investigation. Clin Microbiol Infect. 2006;12:69–74.PubMedCrossRefGoogle Scholar
  143. 143.
    Said MA, Perl TM, Sears CL. Gastrointestinal flu: norovirus in health care and long-term care facilities. Clin Infect Dis. 2008;47:1202–8.PubMedCrossRefGoogle Scholar
  144. 144.
    Cunha BA, Thekkel V, Eisenstein L. Community-acquired norovirus diarrhoea outbreak mimicking a community-acquired C. difficile diarrhoea outbreak. J Hosp Infect. 2008;70:98–100.PubMedCrossRefGoogle Scholar
  145. 145.
    Centers for Disease Control and Prevention (CDC). Norovirus outbreak associated with a natural lake used for recreation – Oregon, 2014. MMWR Morb Mortal Wkly Rep. 2015;64:485–90.Google Scholar
  146. 146.
    Harris JP, Edmunds J, Pebody R, et al. Deaths from norovirus among the elderly, England and Wales. Emerg Infect Dis. 2008;14:1546–52.PubMedPubMedCentralCrossRefGoogle Scholar
  147. 147.
    Verhoef LPB, Kroneman A, van Duynhoven Y, et al. Selection tool for foodborne norovirus outbreaks. Emerg Infect Dis. 2009;15:31–8.PubMedPubMedCentralCrossRefGoogle Scholar
  148. 148.
    Patel MM, Widdowson M-A, Glass RI, et al. Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerg Infect Dis. 2008;14:1224–31.PubMedPubMedCentralCrossRefGoogle Scholar
  149. 149.
    Ludwig A, Adams O, Laws H-J, et al. Quantitative detection of norovirus excretion in pediatric patients with cancer and prolonged gastroenteritis and shedding of norovirus. J Med Virol. 2008;80:1461–7.PubMedCrossRefGoogle Scholar
  150. 150.
    Roos-Weil D, Ambert-Balay K, Lanternier F, et al. Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrhea. Transplantation. 2011;92:61–9.PubMedCrossRefGoogle Scholar
  151. 151.
    Robles JDR, Cheuk DKL, Ha SY, et al. Norovirus infection in pediatric hematopoietic stem cell transplantation recipients: incidence, risk factors, and outcome. Biol Blood Marrow Transplant. 2012;18:1883–9.PubMedCrossRefGoogle Scholar
  152. 152.
    Schwartz S, Vergoulidou M, Schreier E, et al. Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation. Blood. 2011;117:5850–6.PubMedCrossRefGoogle Scholar
  153. 153.
    Schreier E, Doring F, Kunkel U. Molecular epidemiology of outbreaks of gastroenteritis associated with small round structured viruses in Germany in 1997/98. Arch Virol. 2000;145:443–53.PubMedCrossRefGoogle Scholar
  154. 154.
    Kauffman SS, Cahtterjee NK, Fuschino ME, et al. Calicivirus enteritis in an intestinal transplant recipient. Am J Transplant. 2003;3:764–8.CrossRefGoogle Scholar
  155. 155.
    Eid AJ. Posfay-Barbe KM and the AST Infectious Diseases Community of Practice. Am J Transplant. 2009;9 Suppl 4:S147–50.PubMedCrossRefGoogle Scholar
  156. 156.
    Bonvicini F, Marinacci G, Pajno MC, et al. Meningoencephalitis with persistent parvovirus B19 infection in an apparently healthy woman. Clin Infect Dis. 2008;47:384–7.CrossRefGoogle Scholar
  157. 157.
    Douvoyiannis M, Litman N, Goldman DL. Neurologic manifestations associated with parvovirus B19 infection. Clin Infect Dis. 2009;48:1713–23.PubMedCrossRefGoogle Scholar
  158. 158.
    Klumpen H-J, Petersen EJ, Verdonck LF. Severe multiorgan failure after parvovirus B19 infection in an allogeneic stem cell transplant recipient. Bone Marrow Transplant. 2004;34:469–70.PubMedCrossRefGoogle Scholar
  159. 159.
    Laurenz M, Winkelmann B, Roigas J, et al. Severe parvovirus B19 encephalitis after renal transplantation. Pediatr Transplant. 2006;10:978–81.PubMedCrossRefGoogle Scholar
  160. 160.
    Park JB, Kim D-J, Woo S-Y, et al. Clinical implications of quantitative real time-polymerase chain reaction of parvovirus B19 in kidney transplant recipients – a prospective study. Transpl Int. 2009;22:455–62.PubMedCrossRefGoogle Scholar
  161. 161.
    Yango A, Morrissey P, Gohh R, et al. Donor-transmitted parvovirus infection in a kidney transplant recipient presenting as pancytopenia and allograft dysfunction. Transpl Infect Dis. 2002;4:163–6.PubMedCrossRefGoogle Scholar
  162. 162.
    Wasak-Szullkowska E, Grabarczyk P, Rzepecki P. Pure red cell aplasia due to parvovirus B19 infection transmitted probably through hematopoietic stem cell transplantation. Transpl Infect Dis. 2008;10:201–5.CrossRefGoogle Scholar
  163. 163.
    Muetherig A, Christopeit M, Muller LP, et al. Human parvovirus B19 infection with GvHD-like erythema in two allogeneic stem cell transplant recipients. Bone Marrow Transplant. 2007;39:315–6.PubMedCrossRefGoogle Scholar
  164. 164.
    Plentz A, Hahn J, Holler E, et al. Long-term parvovirus B19 viraemia associated with pure red cell aplasia after allogeneic bone marrow transplantation. J Clin Virol. 2004;31:16–9.PubMedCrossRefGoogle Scholar
  165. 165.
    Renoult E, Bachelet C, Krier-Coudert M-J, et al. Recurrent anemia in kidney transplant recipients with parvovirus B19 infection. Transplant Proc. 2006;38:2321–3.PubMedCrossRefGoogle Scholar
  166. 166.
    Beckhoff A, Steffen I, Sandoz P, et al. Relapsing severe anaemia due to primary parvovirus B19 infection after renal transplantation: a case report and review of the literature. Nephrol Dial Transplant. 2007;22:3660–3.PubMedCrossRefGoogle Scholar
  167. 167.
    Ardalan MR, Shoja MM, Tubbs RS, Jayne D. Parvovirus B19 microepidemic in renal transplant recipients with thrombotic microangiopathy and allograft vasculitis. Exp Clin Transplant. 2008;6:137–43.PubMedGoogle Scholar
  168. 168.
    Ardalan MR, Shoja MM, Tubbs RS, et al. Postrenal transplant hemophagocytic lymphohistiocytosis and thrombotic microangiopathy associated with parvovirus B19 infection. Am J Transplant. 2008;8:1340–4.PubMedCrossRefGoogle Scholar
  169. 169.
    Barzon L, Murer L, Pacenti M, et al. Investigation of intrarenal infections in kidney transplant recipients unveils an association between parvovirus B19 and chronic allograft injury. J Infect Dis. 2009;199:372–80.PubMedCrossRefGoogle Scholar
  170. 170.
    Breinholt JP, Moulik M, Dreyer WJ, et al. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010;29:739–46.PubMedPubMedCentralCrossRefGoogle Scholar
  171. 171.
    Allander T, Andreasson K, Gupta S, et al. Identification of a third human polyomavirus. J Virol. 2007;81:4130–6.PubMedPubMedCentralCrossRefGoogle Scholar
  172. 172.
    Gaynor AM, Missen MD, Whiley DM, et al. Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog. 2007;3:595–604.CrossRefGoogle Scholar
  173. 173.
    Sharp CP, Norja P, Anthony I, Bell JE, Simmonds P. Reactivation and mutation of newly discovered WU, KI and Merkel Cell carcinoma polyomaviruses in immunosuppressed individuals. J Infect Dis. 2009;199:398–404.PubMedCrossRefGoogle Scholar
  174. 174.
    Mourez T, Bergeron A, Ribaud P, et al. Polyomaviruses KI and WU in immunocompromised patients with respiratory disease. Emerg Infect Dis. 2009;15:107–9.PubMedPubMedCentralCrossRefGoogle Scholar
  175. 175.
    Dibiaggi M, Canducci F, Brerra R, et al. Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients. J Med Virol. 2010;82:153–6.CrossRefGoogle Scholar
  176. 176.
    Penn I, First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation. 1999;68:1717–21.PubMedCrossRefGoogle Scholar
  177. 177.
    Stelzmueller I, Wiesmayr S, Swenson BR, et al. Rotavirus enteritis in solid organ transplant recipients: an underestimated problem? Transpl Infect Dis. 2007;9:281–5.PubMedCrossRefGoogle Scholar
  178. 178.
    Yin Y, Metselaar HJ, Sprengers D, et al. Rotavirus in organ transplantation: drug-virus-host interactions. Am J Transplant. 2015;15:585–93.PubMedCrossRefGoogle Scholar
  179. 179.
    Haber P, Patel M, Izurieta HS, et al. Postlicensure monitoring of intussusception after RotaTeq vaccination in the United States, February 1, 2006 to September 25, 2007. Pediatrics. 2008;121:1206–12.PubMedCrossRefGoogle Scholar
  180. 180.
    Heyse JF, Kuter BJ, Dallas MJ, et al. Evaluating the safety of a rotavirus vaccine: the REST of the story. Clin Trials. 2008;5:131–9.PubMedPubMedCentralCrossRefGoogle Scholar
  181. 181.
    Reisinger KS, Block SL. Characteristics of an ideal rotavirus vaccine. Clin Pediatr. 2008;47:555–63.CrossRefGoogle Scholar
  182. 182.
    Rubin LG, Levin MJ, Davies EG, et al. 2013 IDSA clinical guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:309–18.PubMedCrossRefGoogle Scholar
  183. 183.
    Gubler DJ. The continuing spread of West Nile virus in the western hemisphere. Clin Infect Dis. 2007;45:1039–46.PubMedCrossRefGoogle Scholar
  184. 184.
    Planitzer CB, Modrof J, Kreil TR. West Nile virus neutralization by US plasma-derived immunoglobulin products. J Infect Dis. 2007;196:435–40.PubMedCrossRefGoogle Scholar
  185. 185.
    Nash D, Mostashari F, Fine A, et al. The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med. 2001;344:1807–14.PubMedCrossRefGoogle Scholar
  186. 186.
    Gea-Banacloche J, Johnson RT, Bagic A, et al. West Nile virus: pathogenesis and therapeutic options. Ann Intern Med. 2004;140:545–53.PubMedCrossRefGoogle Scholar
  187. 187.
    Ferguson DD, Gershman K, LeBailly A, et al. Characteristics of the rash associated with West Nile virus fever. Clin Infect Dis. 2005;41:1204–7.PubMedCrossRefGoogle Scholar
  188. 188.
    Sejvar JJ. The long-tern outcomes of human West Nile virus infection. Clin Infect Dis. 2007;44:1617–24.PubMedCrossRefGoogle Scholar
  189. 189.
    Bode AV, Sejvar JJ, Pape J, et al. West Nile virus disease: a descriptive study of 228 patents hospitalized in a 4-county region of Colorado in 2003. Clin Infect Dis. 2006;42:1234–40.PubMedCrossRefGoogle Scholar
  190. 190.
    Sejvar JJ, Haddad MB, Tierney BC, et al. Neurologic manifestations and outcome of West Nile virus infection. JAMA. 2003;290:511–5.PubMedCrossRefGoogle Scholar
  191. 191.
    Paddock CD, Nicholson WL, Bhatnager J, et al. Fatal hemorrhagic fever caused by West Nile virus in the United States. Clin Infect Dis. 2006;42:1527–35.PubMedCrossRefGoogle Scholar
  192. 192.
    Centers for Disease Control and Prevention (CDC). Possible dialysis-related West Nile virus transmission-Georgia, 2003. MMWR Morb Mortal Wkly Rep. 2004;53:738–9.Google Scholar
  193. 193.
    Iwamoto M, Jernigan DB, Guasch A, et al. Transmission of West Nile virus from an organ donor to four transplant recipients. N Engl J Med. 2003;348:2196–203.PubMedCrossRefGoogle Scholar
  194. 194.
    Centers for Disease Control and Prevention (CDC). Public health dispatch: West Nile virus infection in organ donor and transplant recipients-Georgia and Florida, 2002. MMWR Morb Mortal Wkly Rep. 2002;51:790.Google Scholar
  195. 195.
    Centers for Disease Control and Prevention (CDC). Update: investigations of West Nile virus infections in recipients of organ transplantation and blood transfusion. MMWR Morb Mortal Wkly Rep. 2002;51:833–6.Google Scholar
  196. 196.
    Centers for Disease Control and Prevention (CDC). Public health dispatch: investigations of West Nile virus infections in recipients of blood transfusions. MMWR Morb Mortal Wkly Rep. 2002;51:973–4.Google Scholar
  197. 197.
    Barshes NR, Agee EE, Zgabay T, et al. West Nile virus encephalopathy following pancreatic islet transplantation. Am J Transplant. 2006;6:3037.PubMedCrossRefGoogle Scholar
  198. 198.
    Shepard JC, Subramanian A, Montgomery RA, et al. West Nile virus encephalitis in a kidney transplant recipient. Am J Transplant. 2004;4:830–3.CrossRefGoogle Scholar
  199. 199.
    Armali Z, Ramadan R, Chlebowski A, et al. West Nile meningoencephalitis infection in a kidney transplant recipient. Transplant Proc. 2003;35:2935–6.PubMedCrossRefGoogle Scholar
  200. 200.
    DeSalvo D, Roy-Chaudhury P, Peddi R, et al. West Nile virus encephalitis in organ transplant recipients: another high-risk group for meningoencephalitis and death. Transplantation. 2004;77:466–9.PubMedCrossRefGoogle Scholar
  201. 201.
    Kumar D, Prasad GV, Zaltzman J, et al. Community-acquired West Nile virus infection in solid-organ transplant recipients. Transplantation. 2004;77:399–402.PubMedCrossRefGoogle Scholar
  202. 202.
    Kleinschmidt-DeMasters BK, Marder BA, Levi ME, et al. Naturally acquired West Nile virus encephalitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological features. Arch Neurol. 2004;61:1210–20.PubMedCrossRefGoogle Scholar
  203. 203.
    Penn RG, Guarner J, Sejvar JJ, et al. Persistent neuroinvasive West Nile virus infection in an immunocompromised patient. Clin Infect Dis. 2006;42:680–3.PubMedCrossRefGoogle Scholar
  204. 204.
    Hong DS, Jacobson KL, Raad II, et al. West Nile encephalitis in 2 hematopoietic stem cell transplant recipients: case series and literature review. Clin Infect Dis. 2003;37:1044–9.PubMedCrossRefGoogle Scholar
  205. 205.
    Hiatt B, Desjardin L, Carter T, et al. A fatal case of West Nile virus infection in a bone marrow transplant recipient. Clin Infect Dis. 2003;37:e129–31.PubMedCrossRefGoogle Scholar
  206. 206.
    Tilley PA, Fox JD, Jayaraman GC, et al. Nucleic acid testing for West Nile virus RNA in plasma enhances rapid diagnosis of acute infection in symptomatic patients. J Infect Dis. 2006;193:1361–4.PubMedCrossRefGoogle Scholar
  207. 207.
    Jordan I, Briese T, Fischer N, et al. Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J Infect Dis. 2000;182:1214–7.PubMedCrossRefGoogle Scholar
  208. 208.
    Hamden A, Green P, Mendelson E, et al. Possible benefit of intravenous immunoglobulin therapy in a lung transplant recipient with West Nile virus encephalitis. Transpl Infect Dis. 2002;4:160–2.CrossRefGoogle Scholar
  209. 209.
    Ben-Nathan D, Lustig S, Tam G, et al. Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treating West Nile virus infection in mice. J Infect Dis. 2003;188:5–12.PubMedCrossRefGoogle Scholar
  210. 210.
    Makhoul B, Braun E, Herskovitz M, et al. Hyperimmune gammaglobulin for the treatment of West Nile Virus encephalitis. Isr Med Assoc J. 2009;11:151–3.PubMedGoogle Scholar
  211. 211.
    Carson PJ, Konewko P, Wold KS, et al. Long-term clinical and neuropsychological outcomes of West Nile virus infection. Clin Infect Dis. 2006;43:723–30.PubMedCrossRefGoogle Scholar
  212. 212.
    Morelli MC, Sambri V, Grazi GL, et al. Absence of neuroinvasive disease in a liver transplant recipient who acquired West Nile Virus (WNV) infection from the organ donor and who received WNV antibodies prophylactically. Clin Infect Dis. 2010;51:e34–7.PubMedCrossRefGoogle Scholar
  213. 213.
    Martin JE, Pierson TC, Hubka S, et al. A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase I clinical trial. J Infect Dis. 2007;196:1732–40.PubMedPubMedCentralCrossRefGoogle Scholar
  214. 214.
    Funk GA, Gosert R, Hirsch HH. Viral dynamics in transplant patients: implications for disease. Lancet Infect Dis. 2007;7:460–72.PubMedCrossRefGoogle Scholar
  215. 215.
    Wada K, Kubota N, Ito Y, et al. Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay. J Clin Microbiol. 2007;45:1426–32.PubMedPubMedCentralCrossRefGoogle Scholar
  216. 216.
    Smith TF, Espy MJ, Mandrekar J, et al. Quantitative real-time polymerase chain reaction for evaluating DNAemia due to cytomegalovirus, Epstein-Barr virus, and BK virus in solid-organ transplant recipients. Clin Infect Dis. 2007;45:1056–61.PubMedCrossRefGoogle Scholar
  217. 217.
    Weinberg A, Zamora MR, Li S, et al. The value of polymerase chain reaction for the diagnosis of viral respiratory tract infections on lung transplant recipients. J Clin Virol. 2002;25:171–5.PubMedCrossRefGoogle Scholar
  218. 218.
    Kumar D, Erdman D, Keshavjee S, et al. Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. Am J Transplant. 2005;5:2031–6.PubMedCrossRefGoogle Scholar
  219. 219.
    Matar LD, McAdams HP, Palmer SM, et al. Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation. Radiology. 1999;213:735–42.PubMedCrossRefGoogle Scholar

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© Springer International Publishing Switzerland 2016

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  1. 1.Department of Infectious DiseasesThe Warren Alpert Medical School of Brown UniversityBristolUSA

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