Yeast Infections After Haematopoietic Stem Cell Transplantation

  • Jason A. Trubiano
  • Sharon C.-A. Chen
  • Monica A. Slavin


Invasive fungal disease (IFD) caused by yeasts and yeast-like pathogens complicates both autologous and allogeneic haematopoietic stem cell transplantation (HSCT). Epidemiology varies according to geographic location and antifungal prophylaxis and treatment practices. Invasive candidiasis (IC), including bloodstream infection (candidemia) and deep-seated tissue infection, continues to be the most common yeast infection after HSCT. Risk factors, epidemiology, impact of antifungal prophylaxis, diagnostic approaches including non-culture-based tests and emergence of azole and echinocandin resistance in Candida species are discussed. Risks for, timing of onset after HSCT and treatments for IC as well as infections due to rare and endemic yeasts such as Cryptococcus, Rhodotorula, Trichosporon and Coccidiodes are described.


Candida disease Cryptococcus Trichosporon Antifungal treatment Antifungal resistance Haematopoietic stem cell transplantation 


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© Springer International Publishing Switzerland 2016

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Jason A. Trubiano
    • 1
  • Sharon C.-A. Chen
    • 2
  • Monica A. Slavin
    • 1
  1. 1.Department of Infectious DiseasesPeter MacCallum Cancer CentreMelbourneAustralia
  2. 2.Department of Microbiology and Infectious DiseasesWestmead HospitalSydneyAustralia

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