Hepatobiliary Infections After Solid Organ or Hematopoietic Cell Transplantation



Liver and biliary tract infections are common after solid organ (SOT) or hematopoietic cell transplantation (HCT). SOT recipients who receive liver grafts develop more liver problems than recipients of other organs, but liver issues such as gallstones, viral infections, and cholestasis related to drugs and infection are common after kidney, lung, heart, and pancreas transplants. Hematopoietic cell recipients must also face the toxicity of myeloablative conditioning regimens, absence of cellular immunity pending engraftment, acute and chronic GVHD, and delayed immune reconstitution. When hepatobiliary problems develop after a transplant, there is a wide differential diagnosis that encompasses both infectious and noninfectious causes, and sometimes, both simultaneously.


Solid organ transplant Hematopoietic cell transplant Infection Diagnosis Treatment 


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© Springer International Publishing Switzerland 2016

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  1. 1.Clinical Professor of Medicine, University of Washington HepatologyNorthwest Hospital & Medical Center SeattleWashingtonUSA
  2. 2.Professor of Medicine, Division of Gastroenterology, University of Washington Member, Gastroenterology/HepatologySection, Clinical Research DivisionWashingtonUSA
  3. 3.Clinical Research DivisionFred Hutchinson Cancer Research CenterSeattleUSA
  4. 4.Department of MedicineUniversity of Washington School of MedicineSeattleUSA
  5. 5.Gastroenterology/Hepatology Section (D5-114)Fred Hutchinson Cancer Research CenterSeattleUSA

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