Human Polyomavirus and Papillomavirus Infection and Disease Posttransplant

  • Hans H. Hirsch


Human papillomavirus (HPV) and human polyomavirus (HPyV) infections are widespread in the general population, but cause very little acute illness. However, certain HPV species are the key etiology of condylomata acuminata, cervical cancer, and also anorectal and head-and-neck cancer, and potentially preventable by current vaccines in immunocompetent individuals. In immunocompromised patients, particularly after solid organ transplantation or hematopoietic stem transplantation, HPV and HPyV show an aggravated clinical course. Here, aspects of pathogenesis, diagnosis, and clinical management are discussed for HPyV-associated nephropathy, hemorrhagic cystitis, and progressive multifocal leukoencephalopathy, as well as HPV-associated proliferative disorders of skin and mucosa including cancer.


Polyoma Papilloma Nephropathy Nephritis Cancer Cervix Virus Transplantation 


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© Springer International Publishing Switzerland 2016

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  1. 1.Department of Biomedicine (Transplantation & Clinical Virology) or Clinic for Infectious Diseases & Hospital EpidemiologyUniversity Hospital BaselBaselSwitzerland

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