Human Herpesvirus 6A, 6B, 7, and 8 Infections After Hematopoietic Stem Cell Transplantation



Human herpesvirus (HHV) 6A, HHV-6B, HHV-7, and HHV-8 (also known as Kaposi’s sarcoma associated herpesvirus, or KSHV) are the most recently discovered HHVs. HHV-6B reactivation occurs frequently after hematopoietic stem cell transplantation (HCT), and it is the most common cause of encephalitis in this population. HHV-6B has also been implicated in numerous other disease processes and mortality after HCT, but it is unclear whether its relationship with these outcomes is causal. Complications attributed to HHV-6A and HHV-7 are infrequent, and KSHV is a rare cause of Kaposi’s sarcoma after HCT. The overall clinical impact of reactivation or infection with these viruses requires additional study to determine optimal testing and treatment strategies. Multicenter randomized controlled treatment and prevention trials are needed to explore a causal link between reactivation of these viruses and adverse outcomes in HCT recipients.


Herpesvirus HHV-6 HHV-7 HHV-8 Transplantation HCT 


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© Springer International Publishing Switzerland 2016

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  1. 1.Department of Medicine, Division of Allergy and Infectious DiseasesUniversity of WashingtonSeattleUSA
  2. 2.Vaccine and Infectious Disease DivisionFred Hutchinson Cancer Research CenterSeattleUSA
  3. 3.Department of Pediatrics, Division of Infectious DiseasesUniversity of WashingtonSeattleUSA
  4. 4.Seattle Children’s Research InstituteSeattleUSA

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