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Typical and Atypical Mycobacterium Infections After Hematopoietic Stem Cell or Solid Organ Transplantation

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Transplant Infections

Abstract

Mycobacterial infections are infrequent among recipients of transplantation. These infections are more common among recipients of solid organ versus stem cell transplantation. Mortality is increased with multidrug-resistant strains or disseminated infections. Infection responds well to treatment, provided the diagnosis is made and treatment is initiated early in the course of disease. The incidence of tuberculosis varies by geographical location. Single drug treatment of latent infection is less toxic than multidrug therapy of active infection, so screening for and treating latent infection among high-risk transplant candidates is preferred. Both the tuberculin skin test and interferon gamma release assays can be used to screen for latent infection, which can then be treated prior to initiation of exogenous immunosuppression.

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Authors and Affiliations

  1. Editor-in-Chief, Clinical Microbiology Reviews, American Society of Microbiology, Washington, DC, USA

    Jo-Anne H. Young M.D.

  2. Department of Medicine, University of Minnesota Medical Center, 420 Delaware St. SE, MMC 250, Minneapolis, MN, 55455, USA

    Jo-Anne H. Young M.D. & Daniel J. Weisdorf M.D.

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  1. Jo-Anne H. Young M.D.
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  2. Daniel J. Weisdorf M.D.
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Correspondence to Jo-Anne H. Young M.D. .

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  1. Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Per Ljungman

  2. Tufts University School of Medicine Tufts Medical Center, Boston, MA, USA

    David Snydman

  3. University of Washington Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Michael Boeckh

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Young, JA.H., Weisdorf, D.J. (2016). Typical and Atypical Mycobacterium Infections After Hematopoietic Stem Cell or Solid Organ Transplantation. In: Ljungman, P., Snydman, D., Boeckh, M. (eds) Transplant Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-28797-3_22

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