Typical and Atypical Mycobacterium Infections After Hematopoietic Stem Cell or Solid Organ Transplantation

Chapter

Abstract

Mycobacterial infections are infrequent among recipients of transplantation. These infections are more common among recipients of solid organ versus stem cell transplantation. Mortality is increased with multidrug-resistant strains or disseminated infections. Infection responds well to treatment, provided the diagnosis is made and treatment is initiated early in the course of disease. The incidence of tuberculosis varies by geographical location. Single drug treatment of latent infection is less toxic than multidrug therapy of active infection, so screening for and treating latent infection among high-risk transplant candidates is preferred. Both the tuberculin skin test and interferon gamma release assays can be used to screen for latent infection, which can then be treated prior to initiation of exogenous immunosuppression.

Keywords

Mycobacterium Tuberculosis Hematopoietic stem cell transplant Renal transplant Heart transplant Lung transplant Interferon gamma release assay 

References

  1. 1.
    Timpe A, Runyon EH. The relationship of atypical acid-fast bacteria to human disease; a preliminary report. J Lab Clin Med. 1954;44(2):202–9.PubMedGoogle Scholar
  2. 2.
    Tortoli E. Microbiological features and clinical relevance of new species of the genus Mycobacterium. Clin Microbiol Rev. 2014;27(4):727–52.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Runyon EH. Anonymous mycobacteria in pulmonary disease. Med Clin North Am. 1959;43(1):273–90.PubMedCrossRefGoogle Scholar
  4. 4.
    Johnston RF, Wildrick KH. The impact of chemotherapy on the care of patients with tuberculosis. Am Rev Respir Dis. 1974;109(6):636–64.PubMedGoogle Scholar
  5. 5.
    Peterson EM, Lu R, Floyd C, Nakasone A, Friedly G, de la Maza LM. Direct identification of Mycobacterium tuberculosis, Mycobacterium avium, and Mycobacterium intracellulare from amplified primary cultures in BACTEC media using DNA probes. J Clin Microbiol. 1989;27(7):1543–7.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Wilen CB, McMullen AR, Burnham CA. Comparison of sample preparation, instrumentation platforms, and contemporary commercial databases for MALDI-TOF MS identification of clinically relevant mycobacteria. J Clin Microbiol. 2015;53(7):2308–15.PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    Tran A, Alby K, Kerr A, Jones M, Gilligan PH. Cost savings incurred by implementation of routine microbiological identification by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry. J. Clin. Microbiol. August 2015. 53(8):2473–2479.Google Scholar
  8. 8.
    Good RC, Snider Jr DE. Isolation of nontuberculous mycobacteria in the United States, 1980. J Infect Dis. 1982;146(6):829–33.PubMedCrossRefGoogle Scholar
  9. 9.
    Gruft H, Falkinham 3rd JO, Parker BC. Recent experience in the epidemiology of disease caused by atypical mycobacteria. Rev Infect Dis. 1981;3(5):990–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis. 1979;119(1):107–59.PubMedGoogle Scholar
  11. 11.
    Woods GL, Washington 2nd JA. Mycobacteria other than Mycobacterium tuberculosis: review of microbiologic and clinical aspects. Rev Infect Dis. 1987;9(2):275–94.PubMedCrossRefGoogle Scholar
  12. 12.
    American Thoracic Society. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Crit Care Med. 1997;156(2 Pt 2):S1–25.Google Scholar
  13. 13.
    Ahn CH, McLarty JW, Ahn SS, Ahn SI, Hurst GA. Diagnostic criteria for pulmonary disease caused by Mycobacterium kansasii and Mycobacterium intracellulare. Am Rev Respir Dis. 1982;125(4):388–91.PubMedGoogle Scholar
  14. 14.
    Tubo NJ, Jenkins MK. CD4+ T cells: guardians of the phagosome. Clin Microbiol Rev. 2014;27(2):200–13.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Maeda T, Kusumi E, Kami M, et al. Disseminated tuberculosis following reduced-intensity cord blood transplantation for adult patients with hematological diseases. Bone Marrow Transplant. 2005;35(1):91–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Benito N, Garcia-Vazquez E, Horcajada JP, et al. Clinical features and outcomes of tuberculosis in transplant recipients as compared with the general population: a retrospective matched cohort study. Clin Microbiol Infect. 2015;21(7):651–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Fauci AS, Dale DC. The effect of hydrocortisone on the kinetics of normal human lymphocytes. Blood. 1975;46(2):235–43.PubMedGoogle Scholar
  18. 18.
    Saxon A, Stevens RH, Ramer SJ, Clements PJ, Yu DT. Glucocorticoids administered in vivo inhibit human suppressor T lymphocyte function and diminish B lymphocyte responsiveness in in vitro immunoglobulin synthesis. J Clin Invest. 1978;61(4):922–30.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    Vernon-Roberts B. The effects of steroid hormones on macrophage activity. Int Rev Cytol. 1969;25:131–59.PubMedCrossRefGoogle Scholar
  20. 20.
    Anderson RJ, Schafer LA, Olin DB, Eickhoff TC. Infectious risk factors in the immunosuppressed host. Am J Med. 1973;54(4):453–60.PubMedCrossRefGoogle Scholar
  21. 21.
    Gustafson TL, Schaffner W, Lavely GB, Stratton CW, Johnson HK, Hutcheson Jr RH. Invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy. J Infect Dis. 1983;148(2):230–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Winkelstein A. The effects of azathioprine and 6 MP on immunity. J Immunopharmacol. 1979;1(4):429–54.PubMedCrossRefGoogle Scholar
  23. 23.
    Kahan BD, van Buren CT, Flechner SM, et al. Clinical and experimental studies with cyclosporine in renal transplantation. Surgery. 1985;97(2):125–40.PubMedGoogle Scholar
  24. 24.
    Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science. 1989;246(4937):1617–20.PubMedCrossRefGoogle Scholar
  25. 25.
    Kronke M, Leonard WJ, Depper JM, et al. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A. 1984;81(16):5214–8.PubMedPubMedCentralCrossRefGoogle Scholar
  26. 26.
    Canadian Multicentre Transplant Study Group. A randomized clinical trial of cyclosporine in cadaveric renal transplantation. N Engl J Med. 1983;309(14):809–15.CrossRefGoogle Scholar
  27. 27.
    Najarian JS, Fryd DS, Strand M, et al. A single institution, randomized, prospective trial of cyclosporin versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients. Ann Surg. 1985;201(2):142–57.PubMedPubMedCentralCrossRefGoogle Scholar
  28. 28.
    Novick RJ, Moreno-Cabral CE, Stinson EB, et al. Nontuberculous mycobacterial infections in heart transplant recipients: a seventeen-year experience. J Heart Transplant. 1990;9(4):357–63.PubMedGoogle Scholar
  29. 29.
    Oh CS, Stratta RJ, Fox BC, Sollinger HW, Belzer FO, Maki DG. Increased infections associated with the use of OKT3 for treatment of steroid-resistant rejection in renal transplantation. Transplantation. 1988;45(1):68–73.PubMedCrossRefGoogle Scholar
  30. 30.
    Mason JW, Stinson EB, Hunt SA, Schroeder JS, Rider AK. Infections after cardiac transplantation: relation to rejection therapy. Ann Intern Med. 1976;85(1):69–72.PubMedCrossRefGoogle Scholar
  31. 31.
    Peterson PK, Balfour Jr HH, Fryd DS, Ferguson R, Kronenberg R, Simmons RL. Risk factors in the development of cytomegalovirus-related pneumonia in renal transplant recipients. J Infect Dis. 1983;148(6):1121.PubMedCrossRefGoogle Scholar
  32. 32.
    Singh N, Dummer JS, Kusne S, et al. Infections with Cytomegalovirus and other herpesviruses in 121 liver transplant recipients: transmission by donated organ and the effect of OKT3 antibodies. J Infect Dis. 1988;158(1):124–31.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Subramanian AK, Morris MI, A.S.T. Infectious Diseases Community of Practice. Mycobacterium tuberculosis infections in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:68–76.PubMedCrossRefGoogle Scholar
  34. 34.
    Tomblyn M, Chiller T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009;15(10):1143–238.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    Pai M, Denkinger CM, Kik SV, et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014;27(1):3–20.PubMedPubMedCentralCrossRefGoogle Scholar
  36. 36.
    Kim JS, Cho JH, Park GY, et al. Comparison of QuantiFERON-TB Gold with tuberculin skin test for detection of latent tuberculosis infection before kidney transplantation. Transpl Proc. 2013;45(8):2899–902.CrossRefGoogle Scholar
  37. 37.
    Qin LL, Wang QR, Wang Q, et al. T-SPOT.TB for detection of tuberculosis infection among hematological malignancy patients and hematopoietic stem cell transplant recipients. Asian Pac J Cancer Prev. 2013;14(12):7415–9.PubMedCrossRefGoogle Scholar
  38. 38.
    Lee YM, Lee SO, Choi SH, et al. A prospective longitudinal study evaluating the usefulness of the interferon-gamma releasing assay for predicting active tuberculosis in allogeneic hematopoietic stem cell transplant recipients. J Infect. 2014;69(2):165–73.PubMedCrossRefGoogle Scholar
  39. 39.
    Meyers BR, Halpern M, Sheiner P, Mendelson MH, Neibart E, Miller C. Tuberculosis in liver transplant patients. Transplantation. 1994;58(3):301–6.PubMedCrossRefGoogle Scholar
  40. 40.
    Qunibi WY, al-Sibai MB, Taher S, et al. Mycobacterial infection after renal transplantation—report of 14 cases and review of the literature. Q J Med. 1990;77(282):1039–60.PubMedCrossRefGoogle Scholar
  41. 41.
    Mazurek GH, Jereb J, Lobue P, Iademarco MF, Metchock B, Vernon A. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR Recomm Rep. 2005;54(RR-15):49–55.PubMedGoogle Scholar
  42. 42.
    Mazurek GH, Jereb J, Vernon A, et al. Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection—United States. MMWR Recomm Rep. 2010;59(RR-5):1–25.PubMedGoogle Scholar
  43. 43.
    Kobashi Y, Obase Y, Fukuda M, Yoshida K, Miyashita N, Oka M. Clinical reevaluation of the QuantiFERON TB-2G test as a diagnostic method for differentiating active tuberculosis from nontuberculous mycobacteriosis. Clin Infect Dis. 2006;43(12):1540–6.PubMedCrossRefGoogle Scholar
  44. 44.
    Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med. 2008;149(3):177–84.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Lee SS, Liu YC, Huang TS, et al. Comparison of the interferon-gamma release assay and the tuberculin skin test for contact investigation of tuberculosis in BCG-vaccinated health care workers. Scand J Infect Dis. 2008;40(5):373–80.PubMedCrossRefGoogle Scholar
  46. 46.
    Manuel O, Humar A, Preiksaitis J, et al. Comparison of quantiferon-TB gold with tuberculin skin test for detecting latent tuberculosis infection prior to liver transplantation. Am J Transplant. 2007;7(12):2797–801.PubMedCrossRefGoogle Scholar
  47. 47.
    Codeluppi M, Cocchi S, Guaraldi G, et al. Posttransplant Mycobacterium tuberculosis disease following liver transplantation and the need for cautious evaluation of Quantiferon TB GOLD results in the transplant setting: a case report. Transplant Proc. 2006;38(4):1083–5.PubMedCrossRefGoogle Scholar
  48. 48.
    Nguyen M, Perry S, Parsonnet J. QuantiFERON-TB predicts tuberculin skin test boosting in U.S. foreign-born. Int J Tuberc Lung Dis. 2005;9(9):985–91.PubMedGoogle Scholar
  49. 49.
    Tavil B, Gulhan B, Ozcelik U, et al. Tuberculin skin test positivity in pediatric allogeneic BMT recipients and donors in Turkey. Pediatr Transplant. 2007;11(4):414–8.PubMedCrossRefGoogle Scholar
  50. 50.
    Skinner R, Appleton AL, Sprott MS, et al. Disseminated BCG infection in severe combined immunodeficiency presenting with severe anaemia and associated with gross hypersplenism after bone marrow transplantation. Bone Marrow Transplant. 1996;17(5):877–80.PubMedGoogle Scholar
  51. 51.
    Cordonnier C, Martino R, Trabasso P, et al. Mycobacterial infection: a difficult and late diagnosis in stem cell transplant recipients. Clin Infect Dis. 2004;38(9):1229–36.PubMedCrossRefGoogle Scholar
  52. 52.
    Agarwal SK, Gupta S, Dash SC, Bhowmik D, Tiwari SC. Prospective randomised trial of isoniazid prophylaxis in renal transplant recipient. Int Urol Nephrol. 2004;36(3):425–31.PubMedCrossRefGoogle Scholar
  53. 53.
    Ahmed P, Anwar M, Khan B, et al. Role of isoniazid prophylaxis for prevention of tuberculosis in haemopoietic stem cell transplant recipients. J Pak Med Assoc. 2005;55(9):378–81.PubMedGoogle Scholar
  54. 54.
    John GT, Thomas PP, Thomas M, Jeyaseelan L, Jacob CK, Shastry JC. A double-blind randomized controlled trial of primary isoniazid prophylaxis in dialysis and transplant patients. Transplantation. 1994;57(11):1683–4.PubMedCrossRefGoogle Scholar
  55. 55.
    Budak-Alpdogan T, Tangun Y, Kalayoglu-Besisik S, et al. The frequency of tuberculosis in adult allogeneic stem cell transplant recipients in Turkey. Biol Blood Marrow Transplant. 2000;6(4):370–4.PubMedCrossRefGoogle Scholar
  56. 56.
    Stucchi RSB, Boin IFSF, Angerami RN, Zanaga L, Ataide EC, Udo EY. Is isoniazid safe for liver transplant candidates with latent tuberculosis? Transpl Proc. 2012;44(8):2406–10.CrossRefGoogle Scholar
  57. 57.
    Singh N, Wagener MM, Gayowski T. Safety and efficacy of isoniazid chemoprophylaxis administered during liver transplant candidacy for the prevention of posttransplant tuberculosis. Transplantation. 2002;74(6):892–5.PubMedCrossRefGoogle Scholar
  58. 58.
    Avery RK. Infections after lung transplantation. Semin Respir Crit Care Med. 2006;27(5):544–51.PubMedCrossRefGoogle Scholar
  59. 59.
    Liu M, Yang C, Liu L, et al. Hematopoietic stem cell transplantation for treatment of patients with leukemia concomitant with active tuberculosis infection. Med Sci Monit. 2014;20:2484–8.PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Vikrant S, Agarwal SK, Gupta S, et al. Prospective randomized control trial of isoniazid chemoprophylaxis during renal replacement therapy. Transpl Infect Dis. 2005;7(3–4):99–108.PubMedCrossRefGoogle Scholar
  61. 61.
    Roman A, Bravo C, Levy G, et al. Isoniazid prophylaxis in lung transplantation. J Heart Lung Transplant. 2000;19(9):903–6.PubMedCrossRefGoogle Scholar
  62. 62.
    Naqvi R, Naqvi A, Akhtar S, et al. Use of isoniazid chemoprophylaxis in renal transplant recipients. Nephrol Dial Transpl. 2010;25(2):634–7.CrossRefGoogle Scholar
  63. 63.
    Sud K, Muthukumar T, Singh B, et al. Isoniazid does not affect bioavailability of cyclosporine in renal transplant recipients. Methods Find Exp Clin Pharmacol. 2000;22(8):647–9.PubMedCrossRefGoogle Scholar
  64. 64.
    Torre-Cisneros J, San-Juan R, Rosso-Fernandez CM, et al. Tuberculosis prophylaxis with levofloxacin in liver transplant patients is associated with a high incidence of tenosynovitis: safety analysis of a multicenter randomized trial. Clin Infect Dis. 2015;60(11):1642–9.PubMedCrossRefGoogle Scholar
  65. 65.
    Hernandez-Hernandez E, Alberu J, Gonzalez-Michaca L, et al. Screening for tuberculosis in the study of the living renal donor in a developing country. Transplantation. 2006;81(2):290–2.PubMedCrossRefGoogle Scholar
  66. 66.
    Lee J, Yew WW, Wong CF, Wong PC, Chiu CS. Multidrug-resistant tuberculosis in a lung transplant recipient. J Heart Lung Transplant. 2003;22(10):1168–73.PubMedCrossRefGoogle Scholar
  67. 67.
    Shitrit D, Bendayan D, Saute M, Kramer MR. Multidrug resistant tuberculosis following lung transplantation: treatment with pulmonary resection. Thorax. 2004;59(1):79–80.PubMedPubMedCentralGoogle Scholar
  68. 68.
    Gottesdiener KM. Transplanted infections: donor-to-host transmission with the allograft. Ann Intern Med. 1989;110(12):1001–16.PubMedCrossRefGoogle Scholar
  69. 69.
    Peters TG, Reiter CG, Boswell RL. Transmission of tuberculosis by kidney transplantation. Transplantation. 1984;38(5):514–6.PubMedCrossRefGoogle Scholar
  70. 70.
    Blaschke S, Steffgen J, Grunewald RW, Muller GA. Tuberculous meningitis in a renal transplant recipient. J Nephrol. 2002;15(1):93–5.PubMedGoogle Scholar
  71. 71.
    de la Camara R, Martino R, Granados E, et al. Tuberculosis after hematopoietic stem cell transplantation: incidence, clinical characteristics and outcome. Spanish Group on Infectious Complications in Hematopoietic Transplantation. Bone Marrow Transplant. 2000;26(3):291–8.PubMedCrossRefGoogle Scholar
  72. 72.
    Gaviria JM, Garcia PJ, Garrido SM, Corey L, Boeckh M. Nontuberculous mycobacterial infections in hematopoietic stem cell transplant recipients: characteristics of respiratory and catheter-related infections. Biol Blood Marrow Transplant. 2000;6(4):361–9.PubMedCrossRefGoogle Scholar
  73. 73.
    Roy V, Weisdorf D. Mycobacterial infections following bone marrow transplantation: a 20 year retrospective review. Bone Marrow Transplant. 1997;19(5):467–70.PubMedCrossRefGoogle Scholar
  74. 74.
    Navari RM, Sullivan KM, Springmeyer SC, et al. Mycobacterial infections in marrow transplant patients. Transplantation. 1983;36(5):509–13.PubMedCrossRefGoogle Scholar
  75. 75.
    Aljurf M, Gyger M, Alrajhi A, et al. Mycobacterium tuberculosis infection in allogeneic bone marrow transplantation patients. Bone Marrow Transplant. 1999;24(5):551–4.PubMedCrossRefGoogle Scholar
  76. 76.
    Martino R, Martinez C, Brunet S, Sureda A, Lopez R, Domingo-Albos A. Tuberculosis in bone marrow transplant recipients: report of two cases and review of the literature. Bone Marrow Transplant. 1996;18(4):809–12.PubMedGoogle Scholar
  77. 77.
    Ku SC, Tang JL, Hsueh PR, Luh KT, Yu CJ, Yang PC. Pulmonary tuberculosis in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001;27(12):1293–7.PubMedCrossRefGoogle Scholar
  78. 78.
    Lee J, Lee MH, Kim WS, et al. Tuberculosis in hematopoietic stem cell transplant recipients in Korea. Int J Hematol. 2004;79(2):185–8.PubMedCrossRefGoogle Scholar
  79. 79.
    George B, Mathews V, Srivastava V, Srivastava A, Chandy M. Tuberculosis among allogeneic bone marrow transplant recipients in India. Bone Marrow Transplant. 2001;27(9):973–5.PubMedCrossRefGoogle Scholar
  80. 80.
    Ip MSM, Yuen KY, Woo PCY, et al. Risk factors for pulmonary tuberculosis in bone marrow transplant recipients. Am J Respir Crit Care Med. 1998;158(4):1173–7.PubMedCrossRefGoogle Scholar
  81. 81.
    Ullah K, Raza S, Ahmed P, et al. Pulmonary tuberculosis in allogeneic stem cell transplant recipients. J Pak Med Assoc. 2007;57(11):567–9.PubMedGoogle Scholar
  82. 82.
    Unal E, Yen C, Saiman L, et al. A low incidence of nontuberculous mycobacterial infections in pediatric hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant. 2006;12(11):1188–97.PubMedCrossRefGoogle Scholar
  83. 83.
    Kurzrock R, Zander A, Vellekoop L, Kanojia M, Luna M, Dicke K. Mycobacterial pulmonary infections after allogeneic bone marrow transplantation. Am J Med. 1984;77(1):35–40.PubMedCrossRefGoogle Scholar
  84. 84.
    Eom KS, Lee DG, Lee HJ, et al. Tuberculosis before hematopoietic stem cell transplantation in patients with hematologic diseases: report of a single-center experience. Transpl Infect Dis. 2015;17(1):73–9.PubMedPubMedCentralCrossRefGoogle Scholar
  85. 85.
    Fan WC, Liu CJ, Hong YC, et al. Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study. Int J Tuberc Lung Dis. 2015;19(1):58–64.PubMedCrossRefGoogle Scholar
  86. 86.
    Bekassy AN, Miorner H, Hagerstrand I, Anders F. Graft failure disclosing disseminated Mycobacterium avium-intracellulare infection. Bone Marrow Transplant. 1992;10(5):476.PubMedGoogle Scholar
  87. 87.
    McWhinney PH, Yates M, Prentice HG, Thrussell M, Gillespie SH, Kibbler CC. Infection caused by Mycobacterium chelonae: a diagnostic and therapeutic problem in the neutropenic patient. Clin Infect Dis. 1992;14(6):1208–12.PubMedCrossRefGoogle Scholar
  88. 88.
    Toren A, Ackerstein A, Gazit D, et al. Oral tuberculosis following autologous bone marrow transplantation for Hodgkin’s disease with interleukin-2 and alpha-interferon immunotherapy. Bone Marrow Transplant. 1996;18(1):209–10.PubMedGoogle Scholar
  89. 89.
    Ozkaynak MF, Lenarsky C, Kohn D, Weinberg K, Parkman R. Mycobacterium avium-intracellulare infections after allogeneic bone marrow transplantation in children. Am J Pediatr Hematol Oncol. 1990;12(2):220–4.PubMedCrossRefGoogle Scholar
  90. 90.
    Al-Anazi KA, Al-Jasser AM, Alsaleh K. Infections caused by Mycobacterium tuberculosis in recipients of hematopoietic stem cell transplantation. Front Oncol. 2014;4:231.PubMedPubMedCentralGoogle Scholar
  91. 91.
    Hermida G, Richard C, Baro J, et al. Allogeneic BMT in a patient with CML and prior disseminated infection by Mycobacterium avium complex. Bone Marrow Transplant. 1995;16(1):183–5.PubMedGoogle Scholar
  92. 92.
    Ward MS, Lam KV, Cannell PK, Herrmann RP. Mycobacterial central venous catheter tunnel infection: a difficult problem. Bone Marrow Transplant. 1999;24(3):325–9.PubMedCrossRefGoogle Scholar
  93. 93.
    Ghafari A, Makhdoomi K, Ahmadpoor P, Afshari AT, Fallah MM, Rezaee K. Tuberculosis in Iranian kidney transplant recipients: a single-center experience. Transplant Proc. 2007;39(4):1008–11.PubMedCrossRefGoogle Scholar
  94. 94.
    Queipo JA, Broseta E, Santos M, Sanchez-Plumed J, Budia A, Jimenez-Cruz F. Mycobacterial infection in a series of 1261 renal transplant recipients. Clin Microbiol Infect. 2003;9(6):518–25.PubMedCrossRefGoogle Scholar
  95. 95.
    Sayiner A, Ece T, Duman S, et al. Tuberculosis in renal transplant recipients. Transplantation. 1999;68(9):1268–71.PubMedCrossRefGoogle Scholar
  96. 96.
    Spence RK, Dafoe DC, Rabin G, et al. Mycobacterial infections in renal allograft recipients. Arch Surg. 1983;118(3):356–9.PubMedCrossRefGoogle Scholar
  97. 97.
    Yildiz A, Sever MS, Turkmen A, et al. Tuberculosis after renal transplantation: experience of one Turkish centre. Nephrol Dial Transplant. 1998;13(7):1872–5.PubMedCrossRefGoogle Scholar
  98. 98.
    Hall CM, Willcox PA, Swanepoel CR, Kahn D, Van Zyl Smit R. Mycobacterial infection in renal transplant recipients. Chest. 1994;106(2):435–9.PubMedCrossRefGoogle Scholar
  99. 99.
    Kaaroud H, Beji S, Boubaker K, et al. Tuberculosis after renal transplantation. Transplant Proc. 2007;39(4):1012–3.PubMedCrossRefGoogle Scholar
  100. 100.
    Sakhuja V, Jha V, Varma PP, Joshi K, Chugh KS. The high incidence of tuberculosis among renal transplant recipients in India. Transplantation. 1996;61(2):211–5.PubMedCrossRefGoogle Scholar
  101. 101.
    Apaydin S, Altiparmak MR, Serdengecti K, Ataman R, Ozturk R, Erek E. Mycobacterium tuberculosis infections after renal transplantation. Scand J Infect Dis. 2000;32(5):501–5.PubMedCrossRefGoogle Scholar
  102. 102.
    Malouf MA, Glanville AR. The spectrum of mycobacterial infection after lung transplantation. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1611–6.PubMedCrossRefGoogle Scholar
  103. 103.
    Kesten S, Chaparro C. Mycobacterial infections in lung transplant recipients. Chest. 1999;115(3):741–5.PubMedCrossRefGoogle Scholar
  104. 104.
    Munoz P, Palomo J, Munoz R, Rodriguez-Creixems M, Pelaez T, Bouza E. Tuberculosis in heart transplant recipients. Clin Infect Dis. 1995;21(2):398–402.PubMedCrossRefGoogle Scholar
  105. 105.
    Delaney V, Sumrani N, Hong JH, Sommer B. Mycobacterial infections in renal allograft recipients. Transplant Proc. 1993;25(3):2288–9.PubMedGoogle Scholar
  106. 106.
    Lloveras J, Peterson PK, Simmons RL, Najarian JS. Mycobacterial infections in renal transplant recipients. Seven cases and a review of the literature. Arch Intern Med. 1982;142(5):888–92.PubMedCrossRefGoogle Scholar
  107. 107.
    Malhotra KK, Dash SC, Dhawan IK, Bhuyan UN, Gupta A. Tuberculosis and renal transplantation—observations from an endemic area of tuberculosis. Postgrad Med J. 1986;62(727):359–62.PubMedPubMedCentralCrossRefGoogle Scholar
  108. 108.
    Patel R, Roberts GD, Keating MR, Paya CV. Infections due to nontuberculous mycobacteria in kidney, heart, and liver transplant recipients. Clin Infect Dis. 1994;19(2):263–73.PubMedCrossRefGoogle Scholar
  109. 109.
    Fairhurst RM, Kubak BM, Pegues DA, et al. Mycobacterium haemophilum infections in heart transplant recipients: case report and review of the literature. Am J Transplant. 2002;2(5):476–9.PubMedCrossRefGoogle Scholar
  110. 110.
    Munoz RM, Alonso-Pulpon L, Yebra M, Segovia J, Gallego JC, Daza RM. Intestinal involvement by nontuberculous mycobacteria after heart transplantation. Clin Infect Dis. 2000;30(3):603–5.PubMedCrossRefGoogle Scholar
  111. 111.
    Caliskan Y, Demirturk M, Cagatay AA, et al. Isolated hepatic tuberculous abscess in a renal transplant recipient. Transplant Proc. 2006;38(5):1341–3.PubMedCrossRefGoogle Scholar
  112. 112.
    Czachor JS, Gopalakrishnan R. Coexistent gout and Mycobacterium avium-intracellulare arthritis in a renal transplant recipient. Kidney Blood Press Res. 1997;20(1):62–3.PubMedCrossRefGoogle Scholar
  113. 113.
    de Jong JJ, van Gelder T, Ijzermans JN, Endtz HP, Weimar W. Atypical mycobacterium infection with dermatological manifestation in a renal transplant recipient. Transpl Int. 1999;12(1):71–3.PubMedCrossRefGoogle Scholar
  114. 114.
    Domej W, Wirnsberger GH, Zitta S, et al. Tuberculosis of the small bowel with perforation and hematogenous spread in a renal transplant recipient. Z Gastroenterol. 1993;31(6):401–4.PubMedGoogle Scholar
  115. 115.
    Endzweig CH, Strauss E, Murphy F, Rao BK. A case of cutaneous Mycobacterium chelonae abscessus infection in a renal transplant patient. J Cutan Med Surg. 2001;5(1):28–32.PubMedGoogle Scholar
  116. 116.
    Farooqui MA, Berenson C, Lohr JW. Mycobacterium marinum infection in a renal transplant recipient. Transplantation. 1999;67(11):1495–6.PubMedCrossRefGoogle Scholar
  117. 117.
    Feriozzi S, Meschini L, Costantini S, et al. Fatal intestinal tubercolosis in a uremic patient with a renal transplant. J Nephrol. 2002;15(5):593–6.PubMedGoogle Scholar
  118. 118.
    Jefferson HJ, Ho TB. Tuberculosis after renal transplantation. Nephrol Dial Transplant. 1999;14(5):1341–2.PubMedCrossRefGoogle Scholar
  119. 119.
    Jha V, Sakhuja V, Gupta D, et al. Successful management of pulmonary tuberculosis in renal allograft recipients in a single center. Kidney Int. 1999;56(5):1944–50.PubMedCrossRefGoogle Scholar
  120. 120.
    Lichtenstein IH, MacGregor RR. Mycobacterial infections in renal transplant recipients: report of five cases and review of the literature. Rev Infect Dis. 1983;5(2):216–26.PubMedCrossRefGoogle Scholar
  121. 121.
    Mrowka C, Heintz B, Reul J, Sieberth H. Cerebral tuberculoma 11 years after renal transplantation. Am J Nephrol. 1998;18(6):557–9.PubMedCrossRefGoogle Scholar
  122. 122.
    Neff TA, Hudgel DW. Miliary tuberculosis in a renal transplant recipient. Am Rev Respir Dis. 1973;108(3):677–8.PubMedGoogle Scholar
  123. 123.
    Riska H, Gronhagen-Riska C, Ahonen J. Tuberculosis and renal allograft transplantation. Transplant Proc. 1987;19(5):4096–7.PubMedGoogle Scholar
  124. 124.
    Wong KK, Lim ST, Yeung CK, Ng WL, Ong GB. Disseminated tuberculosis in a renal transplant recipient. Aust N Z J Surg. 1983;53(2):173–5.PubMedCrossRefGoogle Scholar
  125. 125.
    Marques ID, Azevedo LS, Pierrotti LC, et al. Clinical features and outcomes of tuberculosis in kidney transplant recipients in Brazil: a report of the last decade. Clin Transplant. 2013;27(2):E169–76.PubMedCrossRefGoogle Scholar
  126. 126.
    Jereb JA, Kelly GD, Dooley Jr SW, Cauthen GM, Snider Jr DE. Tuberculosis morbidity in the United States: final data, 1990. MMWR CDC Surveill Summ. 1991;40(3):23–7.PubMedGoogle Scholar
  127. 127.
    Meyers BR, Papanicolaou GA, Sheiner P, Emre S, Miller C. Tuberculosis in orthotopic liver transplant patients: increased toxicity of recommended agents; cure of disseminated infection with nonconventional regimens. Transplantation. 2000;69(1):64–9.PubMedCrossRefGoogle Scholar
  128. 128.
    Bodro M, Sabe N, Santin M, et al. Clinical features and outcomes of tuberculosis in solid organ transplant recipients. Transplant Proc. 2012;44(9):2686–9.PubMedCrossRefGoogle Scholar
  129. 129.
    Chen CY, Liu CJ, Feng JY, et al. Incidence and risk factors for tuberculosis after liver transplantation in an endemic area: a nationwide population-based matched cohort study. Am J Transplant. 2015;15(8):2180–7.PubMedCrossRefGoogle Scholar
  130. 130.
    Fairhurst RM, Kubak BM, Shpiner RB, Levine MS, Pegues DA, Ardehali A. Mycobacterium abscessus empyema in a lung transplant recipient. J Heart Lung Transplant. 2002;21(3):391–4.PubMedCrossRefGoogle Scholar
  131. 131.
    Baldi S, Rapellino M, Ruffini E, Cavallo A, Mancuso M. Atypical mycobacteriosis in a lung transplant recipient. Eur Respir J. 1997;10(4):952–4.PubMedGoogle Scholar
  132. 132.
    LeMense GP, VanBakel AB, Crumbley 3rd AJ, Judson MA. Mycobacterium scrofulaceum infection presenting as lung nodules in a heart transplant recipient. Chest. 1994;106(6):1918–20.PubMedCrossRefGoogle Scholar
  133. 133.
    Kristjansson M, Bieluch VM, Byeff PD. Mycobacterium haemophilum infection in immunocompromised patients: case report and review of the literature. Rev Infect Dis. 1991;13(5):906–10.PubMedCrossRefGoogle Scholar
  134. 134.
    Straus WL, Ostroff SM, Jernigan DB, et al. Clinical and epidemiologic characteristics of Mycobacterium haemophilum, an emerging pathogen in immunocompromised patients. Ann Intern Med. 1994;120(2):118–25.PubMedCrossRefGoogle Scholar
  135. 135.
    Ulubay G, Kupeli E, Duvenci Birben O, et al. A 10-year experience of tuberculosis in solid-organ transplant recipients. Exp Clin Transplant. 2015;13 Suppl 1:214–8.PubMedGoogle Scholar
  136. 136.
    Zhang XF, Lv Y, Xue WJ, et al. Mycobacterium tuberculosis infection in solid organ transplant recipients: experience from a single center in China. Transplant Proc. 2008;40(5):1382–5.PubMedCrossRefGoogle Scholar
  137. 137.
    Sever MS, Steinmuller DR, Hayes JM, Streem SB, Novick AC. Pericarditis following renal transplantation. Transplantation. 1991;51(6):1229–32.PubMedCrossRefGoogle Scholar
  138. 138.
    Voigtlander T, Cornberg M, Gottlieb J, Welte T, Suerbaum S, Bange FC. When a respiratory pathogen turns to the skin: cutaneous tuberculosis in a lung transplant patient. Ther Adv Respir Dis. 2015;9(5):260–2.PubMedCrossRefGoogle Scholar
  139. 139.
    John GT, Juneja R, Mukundan U, et al. Gastric aspiration for diagnosis of pulmonary tubercolosis in adult renal allograft recipients. Transplantation. 1996;61(6):972–3.PubMedGoogle Scholar
  140. 140.
    Farrell FJ, Keeffe EB, Man KM, Imperial JC, Esquivel CO. Treatment of hepatic failure secondary to isoniazid hepatitis with liver transplantation. Dig Dis Sci. 1994;39(10):2255–9.PubMedCrossRefGoogle Scholar
  141. 141.
    Marra F, Cox VC, FitzGerald JM, Moadebi S, Elwood RK. Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant. Int J Tuberc Lung Dis. 2004;8(7):905–9.PubMedGoogle Scholar
  142. 142.
    Api TB. Consensus guidelines 2006: management of pulmonary tuberculosis, extra-pulmonary tuberculosis and tuberculosis in special situations. J Assoc Physicians India. 2006;54:219–34.Google Scholar
  143. 143.
    McDiarmid SV, Blumberg DA, Remotti H, et al. Mycobacterial infections after pediatric liver transplantation: a report of three cases and review of the literature. J Pediatr Gastroenterol Nutr. 1995;20(4):425–31.PubMedCrossRefGoogle Scholar
  144. 144.
    John GT, Shankar V. Mycobacterial infections in organ transplant recipients. Semin Respir Infect. 2002;17(4):274–83.PubMedCrossRefGoogle Scholar
  145. 145.
    Le Meur A, Arvieux C, Guggenbuhl P, Cormier M, Jolivet-Gougeon A. Tenosynovitis of the wrist due to resistant Mycobacterium tuberculosis in a heart transplant patient. J Clin Microbiol. 2005;43(2):988–90.PubMedPubMedCentralCrossRefGoogle Scholar
  146. 146.
    Di Perri G, Luzzati R, Forni A, et al. Fatal primary multidrug-resistant tuberculosis in a heart transplant recipient. Transpl Int. 1998;11(4):305–7.PubMedCrossRefGoogle Scholar
  147. 147.
    Altclas J, Lescano A, Salgueira C, et al. Multidrug-resistant tuberculosis in bone marrow transplant recipient. Transpl Infect Dis. 2005;7(1):45–6.PubMedCrossRefGoogle Scholar
  148. 148.
    John GT, Mukundan U, Vincent L, Jacob CK, Shastry JC. Primary drug resistance to Mycobacterium tuberculosis in renal transplant recipients. Natl Med J India. 1995;8(5):211–2.PubMedGoogle Scholar
  149. 149.
    Nagai S, Fujimoto Y, Taira K, et al. Liver transplantation without isoniazid prophylaxis for recipients with a history of tuberculosis. Clin Transplant. 2007;21(2):229–34.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Editor-in-Chief, Clinical Microbiology ReviewsAmerican Society of MicrobiologyWashingtonUSA
  2. 2.Department of MedicineUniversity of Minnesota Medical CenterMinneapolisUSA

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