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Risks and Epidemiology of Infections After Liver Transplantation

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Abstract

Liver transplant recipients have a high risk of infectious complications, compared with recipients of other solid organs, despite the improvement in surgical techniques, shortening of operative times, and the development of novel anti-infective agents in the last decade. A careful examination of risk factors, diligent surveillance for early signs of infection, and prompt intervention are necessary to minimize serious infectious complications, which often contribute to graft loss and death in this population. Future strategies to develop diagnostic assays that are rapid, cost-effective, standardized, and easily performed will improve our abilities to prevent donor-transmitted infections. Ability to assess the immune competence of the recipients and to optimally prescribe appropriate antimicrobial prophylaxis will allow us to prevent infection. Areas such as liver transplant in HIV coinfection and the prevention of recurrence of viral hepatitides after transplantation have made some progress but require further research before the establishment of accepted therapeutic strategies.

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Acknowledgment.

We would like to acknowledge the help of Dr. E. J. Kwak from University of Pittsburgh Medical Center who assisted in writing the previous edition of this chapter.

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Authors and Affiliations

  1. Department of Infectious Diseases, Mayo Clinic, 5777 East Mayo Blvd., Phoenix, AZ, 85054, USA

    Roberto Patron M.D.

  2. Department of Medicine/Infectious Diseases, Mayo Clinic in Arizona, 5777 East Mayo Blvd., Phoenix, AZ, 85054, USA

    Shimon Kusne M.D.

  3. Department of Surgery, Yale New Haven Hospital, 333 Cedar St. FMB 121, New Haven, CT, 06520, USA

    David Mulligan M.D., F.A.C.S.

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  1. Roberto Patron M.D.
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  2. Shimon Kusne M.D.
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  3. David Mulligan M.D., F.A.C.S.
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Correspondence to Shimon Kusne M.D. .

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Editors and Affiliations

  1. Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Per Ljungman

  2. Tufts University School of Medicine Tufts Medical Center, Boston, MA, USA

    David Snydman

  3. University of Washington Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Michael Boeckh

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Patron, R., Kusne, S., Mulligan, D. (2016). Risks and Epidemiology of Infections After Liver Transplantation. In: Ljungman, P., Snydman, D., Boeckh, M. (eds) Transplant Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-28797-3_14

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