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Carbon-Based Nanostructures for Matrix-Free Mass Spectrometry

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Carbon Nanoparticles and Nanostructures

Part of the book series: Carbon Nanostructures ((CARBON))

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a widespread analytical tool for peptides, proteins and most other biomolecules. However, due to a competitive desorption of parasitic ions from the matrix, it is difficult to detect low molecular weight compounds (<700 Da). To enable desorption/ionization of small molecules, techniques operating in absence of an organic matrix were developed. These techniques known as surface assisted laser desorption/ionization mass spectrometry (SALDI-MS) rely on the use of nanostructured surfaces as laser desorption/ionization-assisted material. As compared to traditional MALDI-MS, SALDI-MS offers several advantages such as the ability to detect small molecules (<700 Da), easy sample preparation, low noise background, high salt tolerance and fast data collection. Carbon-based interfaces such as carbon-like graphite, carbon nanotubes, fullerenes or amorphous carbon have been employed as SALDI substrates for the detection of small macromolecules such as synthetic polymers and biomolecules. While the drawback of fullerenes and their derivatives is the general limited sensitivity, carbon nanotubes, which exhibit high sensitivities, are hardly soluble in aqueous solutions, limiting their use in bioanalytical applications. More recently, diamond-like carbon (DLC) and diamond nanowires have been successfully introduced as SALDI interfaces. This chapter summarizes recent developments in the use of carbon-based materials for SALDI-MS. A particular emphasis will be put on the use of diamond nanowires as novel SALDI substrates.

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Acknowledgement

The authors gratefully acknowledge financial support from the Centre National de la Recherche Scientifique (CNRS), the Université Lille 1 and the Nord Pas de Calais region.

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  1. Institut d’Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR 8520), Cité Scientifique, Avenue Poincaré, B.P. 60069, 59652, Villeneuve d’Ascq, France

    Yannick Coffinier, Rabah Boukherroub & Sabine Szunerits

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  1. Yannick Coffinier
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  2. Rabah Boukherroub
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  3. Sabine Szunerits
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Correspondence to Sabine Szunerits .

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  1. Inst of Materials Eng'g, PA-235, University of Siegen, Siegen, Germany

    Nianjun Yang

  2. LOT-Institute of Materials Eng'g, University of Siegen, Siegen, Germany

    Xin Jiang

  3. Wuhan University, Wuhan, China

    Dai-Wen Pang

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Coffinier, Y., Boukherroub, R., Szunerits, S. (2016). Carbon-Based Nanostructures for Matrix-Free Mass Spectrometry. In: Yang, N., Jiang, X., Pang, DW. (eds) Carbon Nanoparticles and Nanostructures. Carbon Nanostructures. Springer, Cham. https://doi.org/10.1007/978-3-319-28782-9_10

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