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Chemoradiation in Esophagogastric Junction Cancer

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Adenocarcinoma of the Esophagogastric Junction

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Abstract

For decades, primary surgery and radiotherapy (RT) alone were two treatment options for potentially curable esophageal cancer. Outcomes were poor, with most patients developing recurrent disease with associated morbidity and mortality. Both treatment options evolved over time as a result of better staging [1–3] and improved surgical [4–6] and radiation techniques [7, 8]. Furthermore, the addition of chemotherapy (CT) to RT and the combination of surgical and nonsurgical approaches were important developments in the treatment of esophageal cancer. However, due to a lack of high-quality evidence, treatment of choice for esophageal cancer still remains controversial. Institutional preferences and clinical opinions still dominate the applied treatments. In this chapter, we give an overview of the role of chemoradiotherapy (CRT) in the treatment of adenocarcinomas (AC) of the distal esophagus and esophagogastric junction (EGJ).

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Authors and Affiliations

  1. Department of Surgery, Erasmus MC – University Medical Center, Suite Z-839, Rotterdam, 3000 CA, The Netherlands

    Bo J. Noordman MD, Bas P. L. Wijnhoven MD, PhD, Joel Shapiro MD & Jan J. B. van Lanschot MD, PhD

  2. Department of Radiotherapy, Academic Medical Center, Amsterdam, The Netherlands

    Maarten C. C. M. Hulshof MD, PhD

  3. Department of Medical Oncology, Erasmus MC – University Medical Center, Rotterdam, The Netherlands

    Ate van der Gaast MD, PhD

Authors
  1. Bo J. Noordman MD
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  2. Bas P. L. Wijnhoven MD, PhD
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  3. Joel Shapiro MD
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  4. Maarten C. C. M. Hulshof MD, PhD
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  5. Ate van der Gaast MD, PhD
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  6. Jan J. B. van Lanschot MD, PhD
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Correspondence to Bo J. Noordman MD .

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Editors and Affiliations

  1. Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

    Simone Giacopuzzi

  2. Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

    Andrea Zanoni

  3. Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

    Giovanni de Manzoni

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Noordman, B.J., Wijnhoven, B.P.L., Shapiro, J., Hulshof, M.C.C.M., van der Gaast, A., van Lanschot, J.J.B. (2017). Chemoradiation in Esophagogastric Junction Cancer. In: Giacopuzzi, S., Zanoni, A., de Manzoni, G. (eds) Adenocarcinoma of the Esophagogastric Junction. Springer, Cham. https://doi.org/10.1007/978-3-319-28776-8_16

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  • DOI: https://doi.org/10.1007/978-3-319-28776-8_16

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