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Stretchable Bioelectronics for Medical Devices and Systems pp 275–291Cite as

In Vitro Neural Recording by Microelectrode Arrays

Part of the Microsystems and Nanosystems book series (MICRONANO)

Abstract

Neural interface SeeAlsoSeeAlsoIn vitro neural recording by microelectrode arrays plays an important role in monitoring and modulating brain activity. In order to study the neural information processing in vitro, microelectrode array (MEA) platform is used with cell culture or brain slice. To measure neural signals simultaneously from multiple cells for long-term period, extracellular neural recording technique is preferred and subcellular-scale microelectrodes , dense array, and flexible substrates are ideal. In this chapter, we will introduce the state-of-the-art in vitro neural recording technology based on microfabricated electrodes or transistors. MEAs with metal-type microelectrodes are passive types, and MEAs with active electronic components (field-effect transistors or integrated circuits) are active types. The motivation, operation principles, fabrication processes and materials, and current trends are reviewed.

Keywords

  • Microelectrode array (MEA)
  • Neural interface
  • Neural recording
  • Action potentials
  • Extracellular recording

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Fig. 14.1
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Authors and Affiliations

  1. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

    Hongki Kang & Yoonkey Nam

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  1. Hongki Kang
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  2. Yoonkey Nam
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Correspondence to Yoonkey Nam .

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  1. Urbana-Champaign, University of Illinois at, Urbana, Illinois, USA

    John A. Rogers

  2. MC10 Inc., Cambridge, Massachusetts, USA

    Roozbeh Ghaffari

  3. School of Chemical and, Seoul National University, Seoul, Korea (Republic of)

    Dae-Hyeong Kim

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Kang, H., Nam, Y. (2016). In Vitro Neural Recording by Microelectrode Arrays. In: Rogers, J., Ghaffari, R., Kim, DH. (eds) Stretchable Bioelectronics for Medical Devices and Systems. Microsystems and Nanosystems. Springer, Cham. https://doi.org/10.1007/978-3-319-28694-5_14

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