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Sleep Disorders in Children pp 155–184Cite as

Pediatric Insomnia

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Abstract

Sleep disorders in children can compromise quality of life of both children and families, and chronic sleep deprivations are associated with poorer developmental outcome, overweight, and behavioral disturbances.

Assessment should follow medical approach and examining primary and secondary contributing factors and maladaptive behaviors related to sleep, and clinicians should incorporate questions about sleep into their routine health assessment of children, examining the sleep/wake schedule, abnormal movements or behavior during sleep, and daytime consequences of sleep deprivation.

Sleeping environment and bedtime routines should be examined to identify behavioral issues related to sleep.

Polysomnography is not routinely indicated for children with insomnia, but actigraphy can give an estimation of objective sleep parameters.

Treatment options include sleep hygiene, behavioral strategies, and pharmacological treatment for selected cases.

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References

  1. Olson LM, Inkelas M, Halfon N, Schuster MA, O’Connor KG, Mistry R. Overview of the content of health supervision for young children: reports from parents and pediatricians. Pediatrics. 2004;113(6 suppl):1907–16.

    PubMed  Google Scholar 

  2. Owens JA, Spirito A, McGuinn M, Nobile C. Sleep habits and sleep disturbance in elementary school-aged children. J Dev Behav Pediatr. 2000;21(1):27–36.

    Article  CAS  PubMed  Google Scholar 

  3. Owens JA, Spirito A, McGuinn M. The Children’s Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep. 2000;23(8):1043–51.

    CAS  PubMed  Google Scholar 

  4. Liu X, Liu L, Owens JA, Kaplan DL. Sleep patterns and sleep problems among schoolchildren in the United States and China. Pediatrics. 2005;115(1 suppl):241–9.

    Article  PubMed  Google Scholar 

  5. Meltzer LJ, Johnson C, Crosette J, Ramos M, Mindell JA. Prevalence of diagnosed sleep disorders in pediatric primary care practices. Pediatrics. 2010;125(6):e1410–8.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sadeh A, Mindell JA, Luedtke K, et al. Sleep and sleep ecology in the first 3 years: a web-based study. J Sleep Res. 2009;18:60–73.

    Article  PubMed  Google Scholar 

  7. Kataria S, Swanson MS, Trevathan GE. Persistence of sleep disturbances in preschool children. J Pediatr. 1987;110:642–6.

    Article  CAS  PubMed  Google Scholar 

  8. Bruni O, Baumgartner E, Sette S, Ancona M, Caso G, Di Cosimo ME, Mannini A, Ometto M, Pasquini A, Ulliana A, Ferri R. Longitudinal study of sleep behavior in normal infants during the first year of life. J Clin Sleep Med. 2014;10(10):1119–27.

    PubMed  PubMed Central  Google Scholar 

  9. Owens JA, Mindell JA. Pediatric insomnia. Pediatr Clin North Am. 2011;58(3):555–69.

    Article  PubMed  Google Scholar 

  10. Owens J, Adolescent Sleep Working Group, Committee on Adolescence. Insufficient sleep in adolescents and young adults: an update on causes and consequences. Pediatrics. 2014;134(3):e921–32.

    Article  PubMed  Google Scholar 

  11. Roberts RE, Roberts CR, Chan W. Persistence and change in symptoms of insomnia among adolescents. Sleep. 2008;31(2):177–84.

    PubMed  PubMed Central  Google Scholar 

  12. Roberts RE, Roberts CR, Duong HT. Chronic insomnia and its negative consequences for health and functioning of adolescents: a 12-month prospective study. J Adolesc Health. 2008;42(3):294–302.

    Article  PubMed  Google Scholar 

  13. Hoban T. Sleep disorders in children. Contin (Minneap Minn). 2013;19(1):185–98.

    Google Scholar 

  14. Roane BM, Taylor DJ. Adolescent insomnia as a risk factor for early adult depression and substance abuse. Sleep. 2008;31(10):1351–6.

    PubMed  PubMed Central  Google Scholar 

  15. Gradisar M, Gardner G, Dohnt H. Recent worldwide sleep patterns and problems during adolescence: a review and meta-analysis of age, region, and sleep. Sleep Med. 2011;12(2):110–8.

    Article  PubMed  Google Scholar 

  16. Hysing M, Pallesen S, Stormark KM, Lundenvold AJ, Sivertsen B. Sleep patterns and insomnia among adolescents: a population-based study. J Sleep Res. 2013;22:549–56.

    Article  PubMed  Google Scholar 

  17. Keyes KM, Maslowsky J, Hamilton A, Schulenberg J. The great sleep recession: changes in sleep duration among US adolescents, 1991–2012. Pediatrics. 2015;135(3):460–8.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Kronholm E, Puusniekka R, Jokela J, Villberg J, Urrila AS, Paunio T, Välimaa R, Tynjälä J. Trends in self-reported sleep problems, tiredness and related school performance among Finnish adolescents from 1984 to 2011. J Sleep Res. 2015;24(1):3–10.

    Article  PubMed  Google Scholar 

  19. Crowley SJ, Acebo C, Carskadon MA. Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Med. 2007;8(6):602–12.

    Article  PubMed  Google Scholar 

  20. Beebe DW, Ris MD, Kramer ME, Long E, Amin R. The association between sleep disordered breathing, academic grades, and cognitive and behavioral functioning among overweight subjects during middle to late childhood. Sleep. 2010;33(11):1447–56.

    PubMed  PubMed Central  Google Scholar 

  21. Matricciani L, Olds T, Petkov J. In search of lost sleep: secular trends in the sleep time of school-aged children and adolescents. Sleep Med Rev. 2012;16(3):203–11.

    Article  PubMed  Google Scholar 

  22. Cain N, Gradisar M. Electronic media use and sleep in school-aged children and adolescents: a review. Sleep Med. 2010;11:735–42.

    Article  PubMed  Google Scholar 

  23. Gradisar M, Wolfson AR, Harvey AG, Hale L, Rosenberg R, Czeisler CA. The sleep and technology use of Americans: findings from the National Sleep Foundation’s 2011 sleep in America Poll. J Clin Sleep Med. 2013;9(12):1291–9.

    PubMed  PubMed Central  Google Scholar 

  24. Bruni O, Alonso-Alconada D, Besag F, Biran V, Braam W, Cortese S, Moavero R, Parisi P, Smits M, Van der Heijden K, Curatolo P. Current role of melatonin in pediatric neurology: clinical recommendations. Eur J Paediatr Neurol. 2015;19(2):122–33.

    Article  PubMed  Google Scholar 

  25. Bruni O, Sette S, Fontanesi L, Baiocco R, Laghi F, Baumgartner E. Technology use and sleep quality in preadolescence and adolescence. J Clin Sleep Med. 2015;11(12):1433–41.

    Google Scholar 

  26. Mindell JA, Sadeh A, Wiegand B, How TH, Goh DY. Cross-cultural differences in infant and toddler sleep. Sleep Med. 2010;11(3):274–80.

    Article  PubMed  Google Scholar 

  27. Angriman M, Caravale B, Novelli L, Ferri R, Bruni O. Sleep in children with neurodevelopmental disabilities. Neuropediatrics. 2015;46(3):199–210.

    Article  PubMed  Google Scholar 

  28. Honaker SM, Meltzer LJ. Bedtime problems and night wakings in young children: an update of the evidence. Paediatr Respir Rev. 2014;15(4):333–9.

    PubMed  Google Scholar 

  29. Byars KC, Yolton K, Rausch J, Lanphear B, Beebe DW. Prevalence, patterns, and persistence of sleep problems in the first 3 years of life. Pediatrics. 2012;129(2):e276–84.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Jenni OG, Fuhrer HZ, Iglowstein I, Molinari L, Largo RH. A longitudinal study of bed sharing and sleep problems among Swiss children in the first 10 years of life. Pediatrics. 2005;115(1 Suppl):233–40.

    Article  PubMed  Google Scholar 

  31. Meltzer LJ, Plaufcan MR, Thomas JH, Mindell JA. Sleep problems and sleep disorders in pediatric primary care: treatment recommendations, persistence, and health care utilization. J Clin Sleep Med. 2014;10(4):421–6.

    PubMed  PubMed Central  Google Scholar 

  32. Beebe DW. Cognitive, behavioral, and functional consequences of inadequate sleep in children and adolescents. Pediatr Clin North Am. 2011;58(3):649–65.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Bell JF, Zimmerman FJ. Shortened nighttime sleep duration in early life and subsequent childhood obesity. Arch Pediatr Adolesc Med. 2010;164(9):840–5.

    Article  PubMed  Google Scholar 

  34. Magee L, Hale L. Longitudinal associations between sleep duration and subsequent weight gain: a systematic review. Sleep Med Rev. 2012;16(3):231–41.

    Article  PubMed  Google Scholar 

  35. Roberts RE, Roberts CR, Chen IG. Impact of insomnia on future functioning of adolescents. J Psychosom Res. 2002;53(1):561–9.

    Article  PubMed  Google Scholar 

  36. Singareddy R, Krishnamurthy VB, Vgontzas AN, Fernandez-Mendoza J, Calhoun SL, Shaffer ML, Bixler EO. Subjective and objective sleep and self-harm behaviors in young children: a general population study. Psychiatry Res. 2013;209(3):549–53.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Wong MM, Brower KJ, Zucker RA. Sleep problems, suicidal ideation, and self-harm behaviors in adolescence. J Psychiatr Res. 2011;45(4):505–11.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Hiscock H, Wake M. Randomised controlled trial of behavioural infant sleep intervention to improve infant sleep and maternal mood. BMJ. 2002;324(7345):1062–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Meltzer LJ, Mindell JA. Relationship between child sleep disturbances and maternal sleep, mood, and parenting stress: a pilot study. J Fam Psychol. 2007;21(1):67–73.

    Article  PubMed  Google Scholar 

  40. Thome M, Skuladottir A. Changes in sleep problems, parents’ distress and impact of sleep problems from infancy to preschool age for referred and unreferred children. Scand J Caring Sci. 2005;19(2):86–94.

    Article  PubMed  Google Scholar 

  41. Hiscock H, Canterford L, Ukoumunne OC, Wake M. Adverse associations of sleep problems in Australian preschoolers: national population study. Pediatrics. 2007;119:86–93.

    Article  PubMed  Google Scholar 

  42. Owens JA, Fernando S, McGuinn M. Sleep disturbance and injury risk in young children. Behav Sleep Med. 2005;3:18–31.

    Article  PubMed  Google Scholar 

  43. Taveras EM, Rifas-Shiman SL, Oken E, Gunderson EP, Gillman MW. Short sleep duration in infancy and risk of childhood overweight. Arch Pediatr Adolesc Med. 2008;162:305–11.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Fatima Y, Doi SA, Mamun AA. Longitudinal impact of sleep on overweight and obesity in children and adolescents: a systematic review and bias-adjusted meta-analysis. Obes Rev. 2015;16(2):137–49.

    Article  CAS  PubMed  Google Scholar 

  45. American Academy of Sleep Medicine. International classification of sleep disorders, 3rd ed. Darien, IL, USA; 2014.

    Google Scholar 

  46. American Academy of Sleep Medicine. International classification of sleep disorders. 2nd ed. Westchester: Diagnostic and coding manual; 2005.

    Google Scholar 

  47. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed. (DSM-5). Washington; 2013.

    Google Scholar 

  48. Miano S, Peraita-Abrados R. Pediatric insomnia: clinical, diagnosis and treatment. Rev Neurol. 2014;58(1):35–42.

    PubMed  Google Scholar 

  49. Perquin CW, Hazebroek-Kampschreur AAJM, Hunfeld JAM, et al. Pain in children and adolescents: a common experience. Pain. 2000;87(1):51–8.

    Article  CAS  PubMed  Google Scholar 

  50. Berrin SJ, Malcarne VL, Varni JW, et al. Pain, fatigue, and school functioning in children with cerebral palsy: a path-analytic model. J Pediatr Psychol. 2007;32(3):330–7.

    Article  PubMed  Google Scholar 

  51. Untley ED, Campo JV, Dahl RE, et al. Sleep characteristics of youth with functional abdominal pain and a healthy comparison group. J Pediatr Psychol. 2007;32(8):938–49.

    Article  Google Scholar 

  52. Long AC, Krishnamurthy V, Palermo TM. Sleep disturbances in school-age children with chronic pain. J Pediatr Psychol. 2008;33(3):258–68.

    Article  PubMed  Google Scholar 

  53. Palermo TM, Wilson AC, Lewandowski AS, et al. Behavioral and psychosocial factors associated with insomnia in adolescents with chronic pain. Pain. 2011;152(1):89–94.

    Article  PubMed  Google Scholar 

  54. Mindell J, Owens J. A clinical guide to pediatric sleep. Philadelphia: Lipincott Williams & Wilkins; 2010.

    Google Scholar 

  55. Bruni O, Ottaviano S, Guidetti V, et al. The sleep disturbance scale for children (SDSC). Construction and validation of an instrument to evaluate sleep disturbance in childhood and adolescence. J Sleep Res. 1996;5:251–61.

    Article  CAS  PubMed  Google Scholar 

  56. Sadeh A. A brief screening questionnaire for infant sleep problems: validation and findings for an internet sample. Pediatrics. 2004;113(6):e570–7.

    Article  PubMed  Google Scholar 

  57. Chervin RD, Hedger K, Dillon JE, Pituch KJ. Pediatric Sleep Questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med. 2000;1:21–32.

    Article  PubMed  Google Scholar 

  58. Kushida CA, Littner MR, Morganthaler T, et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep. 2005;28:499–519.

    PubMed  Google Scholar 

  59. Sadeh A. The role and validity of actigraphy in sleep medicine: un update. Sleep Med Rev. 2011;15(4):259–67.

    Article  PubMed  Google Scholar 

  60. Mindell JA, Emslie G, Blumer J, Genel M, Glaze D, Ivanenko A, Johnson K, Rosen C, Steinberg F, Roth T, Banas B. Pharmacologic management of insomnia in children and adolescents: consensus statement. Pediatrics. 2006;117(6):e1223–32.

    Article  PubMed  Google Scholar 

  61. Mindell JA, Kuhn B, Lewin DS, Meltzer LJ, Sadeh A, American Academy of Sleep Medicine. Behavioral treatment of bedtime problems and night wakings in infants and young children. Sleep. 2006;29(10):1263–76.

    PubMed  Google Scholar 

  62. Morgenthaler T, Kramer M, Alessi C, Friedman L, Boehlecke B, Brown T, Coleman J, Kapur V, Lee-Chiong T, Owens J, Pancer J, Swick T, American Academy of Sleep Medicine. Practice parameters for the psychological and behavioral treatment of insomnia: an update. An american academy of sleep medicine report. Sleep. 2006;29(11):1415–9.

    PubMed  Google Scholar 

  63. Bruni O, Addessi E, Angriman M, Riccioni A, Dosi, Ferri R. Toward a clinical and therapeutic classification of insomnia of childhood. Sleep Med. 2013;S14:e18–92.

    Google Scholar 

  64. Bruni O, Angriman M. Pediatric insomnia: new insights in clinical assessment and treatment options. Arch Ital Biol. 2015;153(2–3):154–66.

    Google Scholar 

  65. Bruni O, Angriman M, Luchetti A, Ferri R. Leg kicking and rubbing as a highly suggestive sign of pediatric RLS. Sleep Med. 2015;16(12):1576–7.

    Article  PubMed  Google Scholar 

  66. Picchietti DL, Rajendran RR, Wilson MP, Picchietti MA. Pediatric restless legs syndrome and periodic limb movement disorder: parent-child pairs. Sleep Med. 2009;10(8):925–31.

    Article  PubMed  Google Scholar 

  67. Tilma J, Tilma K, Norregaard O, Ostergaard JR. Early childhood-onset restless legs syndrome: symptoms and effect of oral iron treatment. Acta Paediatr. 2013;102:e221–6.

    Article  PubMed  Google Scholar 

  68. Gregory AM, Caspi A, Eley TC, Moffitt TE, O’Connor TG, Poulton R. Prospective longitudinal associations between persistent sleep problems in childhood and anxiety and depression disorders in adulthood. J Abnorm Child Psychol. 2005;33:157–63.

    Article  PubMed  Google Scholar 

  69. Greene G, Gregory AM, Fone D, White J. Childhood sleeping difficulties and depression in adulthood: the 1970 British Cohort Study. J Sleep Res. 2015;24:19–23.

    Article  PubMed  Google Scholar 

  70. Monti J. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011;15:269–81.

    Article  PubMed  Google Scholar 

  71. Thakkar MM. Histamine in the regulation of wakefulness. Sleep Med Rev. 2011;15:65–74.

    Article  PubMed  Google Scholar 

  72. Brescianini S, Volzone A, Fagnani C, Patriarca V, Grimaldi V, Lanni R, Serino L, Mastroiacovo P, Stazi MA. Genetic and environmental factors shape infant sleep patterns: a study of 18-month-old twins. Pediatrics. 2011;127(5):e1296–302.

    Article  PubMed  Google Scholar 

  73. Touchette E, Dionne G, Forget-Dubois N, Petit D, Pérusse D, Falissard B, Tremblay RE, Boivin M, Montplaisir JY. Genetic and environmental influences on daytime and nighttime sleep duration in early childhood. Pediatrics. 2013;131(6):e1874–80.

    Article  PubMed  Google Scholar 

  74. LeBlanc M, Mérette C, Savard J, Ivers H, Baillargeon L, Morin CM. Incidence and risk factors of insomnia in a population-based sample. Sleep. 2009;32(8):1027–37.

    PubMed  PubMed Central  Google Scholar 

  75. Harvey CJ, Gehrman P, Espie CA. Who is predisposed to insomnia: a review of familial aggregation, stress-reactivity, personality and coping style. Sleep Med Rev. 2014;18:237–47.

    Article  PubMed  Google Scholar 

  76. Palagini L, Biber K, Riemann D. The genetics of insomnia – evidence for epigenetic mechanisms? Sleep Med Rev. 2014;18(3):225–35.

    Article  PubMed  Google Scholar 

  77. Sadeh A. Assessment of intervention for infant night waking: parental reports and activity-based home monitoring. J Consult Clin Psychol. 1994;62:63–8.

    Article  CAS  PubMed  Google Scholar 

  78. Galland BC, Mitchell EA. Helping children sleep. Arch Dis Child. 2010;95(10):850–3.

    Article  PubMed  Google Scholar 

  79. Owens J, Maxim R, McGuinn M, Nobile C, Msall M, Alario A. Television-viewing habits and sleep disturbance in school children. Pediatrics. 1999;104(3):e27.

    Article  CAS  PubMed  Google Scholar 

  80. Davis KF, Parker KP, Montgomery GL. Sleep in infants and young children: part one: normal sleep. J Pediatr Health Care. 2004;18(2):65–71.

    Article  PubMed  Google Scholar 

  81. Driver HS, Taylor SR. Exercise and sleep. Sleep Med Rev. 2000;4(4):387–402.

    Article  PubMed  Google Scholar 

  82. Mindell JA, Meltzer LJ, Carskadon MA, Chervin RD. Developmental aspects of sleep hygiene: findings from the 2004 National Sleep Foundation Sleep in America Poll. Sleep Med. 2009;10(7):771–9.

    Article  PubMed  Google Scholar 

  83. Hiscock H, Bayer JK, Hampton A, Ukoumunne OC, Wake M. Long-term mother and child mental health effects of a population-based infant sleep intervention: cluster-randomized, controlled trial. Pediatrics. 2008;122:e621–7.

    Article  PubMed  Google Scholar 

  84. Price AM, Wake M, Ukoumunne OC, Hiscock H. Outcomes at six years of age for children with infant sleep problems: longitudinal community-based study. Sleep Med. 2012;13:991–8.

    Article  PubMed  Google Scholar 

  85. Adachi Y, Sato C, Nishino N, Ohryoji F, Hayama J, Yamagami T. A brief parental education for shaping sleep habits in 4-month-old infants. Clin Med Res. 2009;7:85–92.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Meltzer LJ. Clinical management of behavioral insomnia of childhood: treatment of bedtime problems and night wakings in young children. Behav Sleep Med. 2010;8(3):172–89.

    Article  PubMed  Google Scholar 

  87. Tikotzky L, Sadeh A. The role of cognitive–behavioral therapy in behavioral childhood insomnia. Sleep Med. 2010;11(7):686–91.

    Article  PubMed  Google Scholar 

  88. Taylor DJ, Roane BM. Treatment of insomnia in adults and children: a practice-friendly review of research. J Clin Psychol. 2010;66(11):1137–47.

    Article  PubMed  Google Scholar 

  89. Meltzer LJ, Mindell JA. Systematic review and meta-analysis of behavioral interventions for pediatric insomnia. J Pediatr Psychol. 2014;39:932–48.

    Article  PubMed  Google Scholar 

  90. Pelayo R, Yuen K. Pediatric sleep pharmacology. Child Adolesc Psychiatr Clin N Am. 2012;21(4):861–83.

    Article  PubMed  Google Scholar 

  91. Pelayo R, Dubik M. Pediatric sleep pharmacology. Semin Pediatr Neurol. 2008;15(2):79–90.

    Article  PubMed  Google Scholar 

  92. Bruni O, Ferri R, Miano S, Verrillo E. L-5-hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr. 2004;163(7):402–7.

    Article  CAS  PubMed  Google Scholar 

  93. Bruni O, Violani C, Luchetti A, Miano S, Verrillo E, Di Brina C, Valente D. The sleep knowledge of pediatricians and child neuropsychiatrists. Sleep Hypn. 2004;6(3):130–8.

    Google Scholar 

  94. Owens JA. Pharmacotherapy of pediatric insomnia. J Am Acad Child Adolesc Psychiatry. 2009;48(2):99–107.

    Article  PubMed  Google Scholar 

  95. Heussler H, Chan P, Price AM, Waters K, Davey MJ, Hiscock H. Pharmacological and non-pharmacological management of sleep disturbance in children: an Australian Paediatric Research Network survey. Sleep Med. 2013;14(2):189–94.

    Article  PubMed  Google Scholar 

  96. Lieberman HR, Corkin S, Spring BJ, Wurtman RJ, Growdon JH. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr. 1985;42(2):366–70.

    CAS  PubMed  Google Scholar 

  97. Körner E, Bertha G, Flooh E, Reinhart B, Wolf R, Lechner H. Sleep-inducing effect of L-tryptophan. Eur Neurol. 1986;25 Suppl 2:75–81.

    PubMed  Google Scholar 

  98. Schneider-Helmert D, Spinweber CL. Evaluation of L-tryptophan for treatment of insomnia: a review. Psychopharmacology (Berl). 1986;89(1):1–7.

    Article  CAS  Google Scholar 

  99. Hartmann E, Spinweber CL. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. J Nerv Ment Dis. 1979;167(8):497–9.

    Article  CAS  PubMed  Google Scholar 

  100. Meoli AL, Rosen C, Kristo D, et al. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. J Clin Sleep Med. 2005;1(2):173–87.

    Google Scholar 

  101. Das YT, Bagchi M, Bagchi D, Preuss HG. Safety of 5-hydroxy-L-tryptophan. Toxicol Lett. 2004;150(1):111–22.

    Article  CAS  PubMed  Google Scholar 

  102. Mignot E, Taheri S, Nishino S. Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nat Neurosci. 2002;5:1071–5.

    Article  CAS  PubMed  Google Scholar 

  103. Russo RM, Gururaj VJ, Allen JE. The effectiveness of diphenhydramine HCI in pediatric sleep disorders. J Clin Pharmacol. 1976;16(5–6):284–8.

    Article  CAS  PubMed  Google Scholar 

  104. Merenstein D, Diener-West M, Halbower AC, Krist A, Rubin HR. The trial of infant response to diphenhydramine: the TIRED study – a randomized, controlled, patient-oriented trial. Arch Pediatr Adolesc Med. 2006;160(7):707–12.

    Article  PubMed  Google Scholar 

  105. Gringras P. When to use drugs to help sleep. Arch Dis Child. 2008;93(11):976–81.

    Article  CAS  PubMed  Google Scholar 

  106. France KG, Blampied NM, Wilkinson P. A multiple-baseline, double-blind evaluation of the effects of trimeprazine tartrate on infant sleep disturbance. Exp Clin Psychopharmacol. 1999;7(4):502–13.

    Article  CAS  PubMed  Google Scholar 

  107. Ottaviano S, Giannotti F, Cortesi F. The effect of niaprazine on some common sleep disorders in children. A double-blind clinical trial by means of continuous home-video recorded sleep. Childs Nerv Syst. 1991;7(6):332–5.

    Article  CAS  PubMed  Google Scholar 

  108. Montanari G, Schiaulini P, Covre A, Steffan A, Furlanut M. Niaprazine vs chlordesmethyldiazepam in sleep disturbances in pediatric outpatients. Pharmacol Res. 1992;25 Suppl 1:83–4.

    Article  CAS  PubMed  Google Scholar 

  109. van Geijlswijk IM, van der Heijden KB, Egberts AC, Korzilius HP, Smits MG. Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. Psychopharmacology (Berl). 2010;212(3):379–91.

    Article  CAS  Google Scholar 

  110. Phillips L, Appleton RE. Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. Dev Med Child Neurol. 2004;46(11):771–5.

    Article  PubMed  Google Scholar 

  111. Braam W, Didden R, Maas AP, Korzilius H, Smits MG, Curfs LM. Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. J Intellect Disabil Res. 2010;54(1):52–9.

    Article  CAS  PubMed  Google Scholar 

  112. Van der Heijden KB, Smits MG, Van Someren EJ, Gunning WB. Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int. 2005;22(3):559–70.

    Article  PubMed  Google Scholar 

  113. Van der Heijden KB, Smits MG, Van Someren EJ, Ridderinkhof KR, Gunning WB. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad Child Adolesc Psychiatry. 2007;46(2):233–41.

    Article  PubMed  Google Scholar 

  114. Smits MG, van Stel HF, van der Heijden K, Meijer AM, Coenen AM, Kerkhof GA. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2003;42(11):1286–93.

    Article  PubMed  Google Scholar 

  115. Weiss MD, Wasdell MB, Bomben MM, Rea KJ, Freeman RD. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry. 2006;45(5):512–9.

    Article  PubMed  Google Scholar 

  116. Appleton RE, Jones AP, Gamble C, et al. The use of Melatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS). Health Technol Assess. 2012;16(40):i–239.

    Article  CAS  PubMed  Google Scholar 

  117. Kordas K, Siegel EH, Olney DK, Katz J, Tielsch JM, Chwaya HM, Kariger PK, Leclerq SC, Khatry SK, Stoltzfus RJ. Maternal reports of sleep in 6-18-month-old infants from Nepal and Zanzibar: association with iron deficiency anemia and stunting. Early Hum Dev. 2008;84(6):389–98.

    Article  PubMed  Google Scholar 

  118. Kordas K, Siegel EH, Olney DK, Katz J, Tielsch JM, Kariger PK, Khalfan SS, LeClerq SC, Khatry SK, Stoltzfus RJ. The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar. J Dev Behav Pediatr. 2009;30(2):131–9.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol. 2004;56(6):803–7.

    Article  PubMed  Google Scholar 

  120. Picchietti DL, Stevens HE. Early manifestations of restless legs syndrome in childhood and adolescence. Sleep Med. 2008;9:770–81.

    Article  PubMed  Google Scholar 

  121. Kryger MH, Otake K, Foerster J. Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers. Sleep Med. 2002;3(2):127–32.

    Article  PubMed  Google Scholar 

  122. McCarty DE, Chesson Jr AL, Jain SK, Marino AA. The link between vitamin D metabolism and sleep medicine. Sleep Med Rev. 2014;18(4):311–9.

    Article  PubMed  Google Scholar 

  123. Prince JB, Wilens TE, Biederman J, et al. Clonidine for sleep disturbances associated with attention-deficit hyperactivity disorder: a systematic chart review of 62 cases. J Am Acad Child Adolesc Psychiatr. 1996;35(5):599–605.

    Article  CAS  Google Scholar 

  124. Nguyen M, Tharani S, Rahmani M, Shapiro M. A review of the use of clonidine as a sleep aid in the child and adolescent population. Clin Pediatr (Phila). 2014;53(3):211–6.

    Article  Google Scholar 

  125. Kotagal S. Treatment of dyssomnias and parasomnias in childhood. Curr Treat Options Neurol. 2012;14(6):630–49.

    Article  PubMed  Google Scholar 

  126. Owens JA, Babcock D, Blumer J, Chervin R, Ferber R, Goetting M, Glaze D, Ivanenko A, Mindell J, Rappley M, Rosen C, Sheldon S. The use of pharmacotherapy in the treatment of pediatric insomnia in primary care: rational approaches. A consensus meeting summary. J Clin Sleep Med. 2005;1(1):49–59.

    PubMed  Google Scholar 

  127. Zisapel N. Drugs for insomnia. Expert Opin Emerg Drugs. 2012;17(3):299–317.

    Article  CAS  PubMed  Google Scholar 

  128. Blumer JL, Findling RL, Shih WJ, Soubrane C, Reed MD. Controlled clinical trial of zolpidem for the treatment of insomnia associated with attention-deficit/hyperactivity disorder in children 6 to 17 years of age. Pediatrics. 2009;123:e770–6.

    Article  PubMed  Google Scholar 

  129. Liskow B, Pikalov A. Zaleplon overdose associated with sleepwalking and complex behavior. J Am Acad Child Adolesc Psychiatr. 2004;43(8):927–8.

    Article  Google Scholar 

  130. Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated? Paediatr Drugs. 2002;4(6):391–403.

    Article  PubMed  Google Scholar 

  131. Wichniak A, Wierzbicka A, Jernajczyk W. Sleep and antidepressant treatment. Curr Pharm Des. 2012;18:5802–17.

    Article  CAS  PubMed  Google Scholar 

  132. Carrey N, Baath S. Trazodone for sleep in children. Child Adolesc Psychopharmacol News. 1996;1:10–1.

    Google Scholar 

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Authors and Affiliations

  1. Department of Developmental and Social Psychology, S. Andrea Hospital, Sapienza University, Via dei Marsi 78, Rome, Italy

    Oliviero Bruni

  2. Department of Pediatrics, Child Neurology and Neurorehabilitation Unit, Central Hospital of Bolzano, Bohler Street 5, Bolzano, 39100, Italy

    Marco Angriman

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  1. Oliviero Bruni
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  2. Marco Angriman
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Correspondence to Oliviero Bruni .

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Editors and Affiliations

  1. Department of Neurology, Charles University and General Teaching Hospital, Prague, Czech Republic

    Soňa Nevšímalová

  2. Sapienza University, S. Andrea Hospital, Department of Developmental and Social Psychology, Rome, Roma, Italy

    Oliviero Bruni

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Bruni, O., Angriman, M. (2017). Pediatric Insomnia. In: Nevšímalová, S., Bruni, O. (eds) Sleep Disorders in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-28640-2_9

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