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Guillain–Barré Syndrome and Campylobacter jejuni Enteritis

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Neuro-Immuno-Gastroenterology

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Abstract

Guillain–Barré syndrome is an immune-mediated neuropathy that accounts for one of the most common acute neuromuscular paralysis worldwide. Characteristic to its history is an antecedent illness and this includes Campylobacter jejuni enteritis. The pathogenesis of C. jejuni-related Guillain–Barré syndrome has been extensively studied, and there is good evidence to support molecular mimicry between self and microbial components as the mechanism of disease. Self-antigens in the form of gangliosides which are predominantly cell-surface glycolipids highly expressed in nervous tissue share similar characteristics as lipo-oligosaccharides of C. jejuni outer membrane. Molecular mimicry has been demonstrated between GM1 ganglioside and lipo-oligosaccharide of C. jejuni isolated from Guillain–Barré syndrome patients. This includes the establishment of disease models by sensitisation of rabbits with GM1 and C. jejuni lipo-oligosaccharide. This chapter discusses the current understanding of Guillain–Barré syndrome following C. jejuni enteritis.

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Author information

Authors and Affiliations

  1. Department of Neurology, University Malaya Medical Centre, Kuala Lumpur, Malaysia

    Nortina Shahrizaila DM, FRCP

  2. Departments of Medicine and Physiology, National University of Singapore, Neuroscience Research Centre, Centre for Translational Medicine, Singapore, Singapore

    Nobuhiro Yuki MD, PhD

Authors
  1. Nortina Shahrizaila DM, FRCP
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  2. Nobuhiro Yuki MD, PhD
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Correspondence to Nobuhiro Yuki MD, PhD .

Editor information

Editors and Affiliations

  1. Neurology, C Floor South Block, University of Nottingham, Nottingham, United Kingdom

    Cris Constantinescu

  2. Atlantic Digestive Health Institute, Morristown Medical Center, Columbus, Ohio, USA

    Razvan Arsenescu

  3. Armedica LLC, Columbus, Ohio, USA

    Violeta Arsenescu

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Shahrizaila, N., Yuki, N. (2016). Guillain–Barré Syndrome and Campylobacter jejuni Enteritis. In: Constantinescu, C., Arsenescu, R., Arsenescu, V. (eds) Neuro-Immuno-Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-28609-9_9

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  • DOI: https://doi.org/10.1007/978-3-319-28609-9_9

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  • Online ISBN: 978-3-319-28609-9

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