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Cancer-Induced Inflammation

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Book cover Oncodynamics: Effects of Cancer Cells on the Body

Abstract

The relationship between inflammation and cancer has long been discussed, ever since Virchow first postulated the role of chronic inflammation in the onset of cancer. Though much research since then has focused on inflammation-induced cancer, it is of equal importance to consider the impact tumour cells can have on the immune system. Stemming from the broader concept of “oncodynamics”, this chapter will discuss cancer-induced inflammation and immunosuppression caused by the release of tumour-derived factors that act on the body’s immune cells.

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Abbreviations

ARG1:

Arginase 1

CSF1:

Colony stimulating factor 1

CTL:

Cytotoxic T lymphocyte (CD8+ T-cell)

DC:

Dendritic cell

FOXP3:

Forkhead box P3

IFN:

Interferon

IL:

Interleukin

iMC:

Immature myeloid cell

iNOS:

Inducible nitric oxide synthase

JAK:

Janus kinase

LPS:

Lipopolysaccharide

M-CSF:

Macrophage colony-stimulating factor

MDSC:

Myeloid-derived suppressor cell

MHC:

Major histocompatibility complex

MSC:

Myeloid suppressor cell

NF-κB:

Nuclear factor kappa B

NK:

Natural killer

NO:

Nitric oxide

NOS2:

Inducible nitric oxide synthase

ROS:

Reactive oxygen species

STAT:

Signal transducer and activator of transcription

TAM:

Tumour-associated macrophage

TAN:

Tumour-associated neutrophil

TCR:

T cell receptor

TGF-β:

Transforming growth factor beta

TLR:

Toll-like receptor

TME:

Tumour microenvironment

TNF:

Tumour necrosis factor

Treg :

Regulatory T cell

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada

    Kimberly Young & Gurmit Singh

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  1. Kimberly Young
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  2. Gurmit Singh
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Correspondence to Gurmit Singh .

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Editors and Affiliations

  1. Dept. Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

    Gurmit Singh

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Young, K., Singh, G. (2016). Cancer-Induced Inflammation. In: Singh, G. (eds) Oncodynamics: Effects of Cancer Cells on the Body. Springer, Cham. https://doi.org/10.1007/978-3-319-28558-0_4

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