Abstract
Avocados have a high content of phytochemicals especially antioxidants with potential neuroprotective effect. Aging is the major risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. A large body of evidence indicates that oxidative stress is involved in the pathophysiology of these diseases. Oxidative stress can induce neuronal damages and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. There is evidence for increased oxidative damage to macromolecules in amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, and Alzheimer’s disease. Thus, antioxidants have been used for their effectiveness in reducing these deleterious effects and neuronal death in many in vitro and in vivo studies. The critical review results indicate that compounds in avocado are unique antioxidants, preferentially suppressing radical generation, and thus may be promising as effective neuropreventive agents. The diverse array of bioactive nutrients present in avocado plays a pivotal role in the prevention and cure of various neurodegenerative diseases.
Keywords
- Avocado
- Neuron
- Alzheimer’s disease (AD)
- Antioxidants
An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-28383-8_24
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References
Acar A, Akil E, Alp H, et al. Oxidative damage is ameliorated by curcumin treatment in the brain and sciatic nerve of diabetic rats. Int J Neurosci. 2012;122(7):367–72.
ADA (American Dietetic Association). Position of the American Dietetic Association: functional foods. J Am Diet Assoc. 2009;109:735–46.
Alberti KG, Zimmer PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.
Bresgen N, Karlhuber G, Krizbai I, Bauer H, Bauer HC, Eckl PM. Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis. J Neurosci Res. 2003;72:327–33.
Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer’s disease. Alzheimers Demen. 2007;3(3):186–91.
Carranza-Madrigal J, Alvizouri-Mũnoz M, Herrera-Abarca JE, Chávez-Carbajal F. Efectos del aguacatecomofuente de ácidosgrasosmonoinsaturados en lìpidosséricos, metabolismo de la glucosa y reología en pacientes con diabetes tipo 2. Med Intern México. 2008;24(4):267–72.
Ceretta LB, Réus GZ, Rezin GT, Scaini G, Streck EL, Quevedo J. Brain energy metabolism parameters in an animal model of diabetes. Metab Brain Dis. 2010;25(4):391–6.
Ceretta LB, Réus GZ, Abelaira HM, et al. Increased oxidative stress and imbalance in antioxidant enzymes in the brains of alloxan-induced diabetic rats. Exp Diabetes Res. 2012;2012:302682. 8 pages.
Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr. 2000;71:621S–9.
Crews C, Hough P, Godward J. Study of the main constituents of some authentic walnut oils. J Agric Food Chem. 2005;53:4853–60.
Demopoulos HB, Flamm ES, Pietronegro DD, Seligman ML. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl. 1980;492:91–119.
Dreher ML, Davenport AJ. Hass avocado composition and potential health effects. Crit Rev Food Sci Nutr. 2013;53(7):738–50.
Duster KC. Avocados a look beyond basic nutrition for one of nature’s whole foods. Nutr Today. 2000;35(4):151–7.
Edwards JL, Quattrini A, Lentz SI, et al. Diabetes regulates mitochondrial biogenesis and fission in mouse neurons. Diabetologia. 2010;53(1):160–9.
Finkel T. Signal transduction by reactive oxygen species. J Cell Biol. 2011;194(1):7–15.
Freidovich I. Fundamental aspects of reactive oxygen species, or what’s the matter with oxygen? N Y Acad Sci. 1999;893:13.
Gilgun-Sherki Y, Melamed E, Offen D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology. 2001;40:959–75.
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta 42 fibrils. Science. 2001;293:1491–5.
Growers CA. Available from: http://www.californiaavocadogrowers.com/; 2012.
Haegele AD, Gillette C, O’Neill C, Wolfe P, Heimendinger J, Sedlacek S, Thompson HJ. Plasma xanthophyll carotenoids correlate inversely with indices of oxidative DNA damage and lipid peroxidation AMC cancer. Cancer Epidemiol Biomarkers Prev. 2000;9:421–5.
Halliwell B. Reactive oxygen species and central nervous systems. J Neurochem. 1992;59:1609–23.
Harper PS. The epidemiology of Huntington’s disease. Hum Genet. 1992;89(4):365–76.
Hashimura H, Ueda C, Kawabata J, Kasai T. Acetyl-CoA carboxylase inhibitors from avocado (Persea americana Mill) fruits. Biosci Biotechnol Biochem. 2001;65:1656–8.
http://www.naturalnews.com/040067-avocado-cancer-prevention- superfood. html#ixzz2Rb7Hjbxs.
Hughes KJ, Mayne ST, Blumberg JB, Ribaya-Mercardo JD, Johnson EJ, Cartmel B. Plasma carotenoids and biomarkers of oxidative stress in patients with prior head and neck cancer. Biomark Insights. 2009;4:17–26.
Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci. 1999;19:8114–21.
Kim OK, Murakami A, Takahashi D, Nakamura Y, Torikai K, Kim HW, Ohigashi H. An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin. Biosci Biotechnol Biochem. 2000a;64:2504–7.
Kim OK, Murakami A, Nakamura Y, Kim HW, Ohigash H. Inhibition by persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes. Biosci Biotechnol Biochem. 2000b;64:2500–3.
KolominskyRabas PL, Sarti C, Heuschmann PU, Graf C, Siemonsen S, Neundoerfer B, et al. A prospective community based study of stroke in Germany. The Erlangen Stroke Project (ESPro): incidence and case fatality at 1, 3, and 12 months. Stroke. 1998;29:2501–6.
Kumar V. Potential medicinal plants for CNS disorders: an overview. Phytother Res. 2006;20:1023–35.
Kurtzke JF. Epidemiology of amyotrophic lateral sclerosis. Adv Neurol. 1982;36:281–302.
Lamers Y. Folate recommendations for pregnancy, lactation, and infancy. Ann Nutr Metab. 2011;59(1):32–7.
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001;21:8370–7.
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4:118–26 [PMCID: PMC3249911].
McCann JC, Ames BN. Is docosahexaenoic acid, an n23 long chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr. 2005;82:281–95.
Mecocci P, Polidori MC, Ingegni T, Cherubini A, Chionne F, Cecchetti R, Senin U. Oxidative damage to DNA in lymphocytes from AD patients. Neurology. 1998;51:1014–7.
Migliore L, Fontana I, Trippi F, Colognato R, Coppede F, Tognoni G, Nucciarone B, Siciliano G. Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol Aging. 2005;26:567–73.
Moreira PI, Oliveira CR. Mitochondria as potential targets in antidiabetic therapy. In: Schwanstecher M, editor. Diabetes—perspectives in drug therapy, vol. 203 of Handbook of experimental pharmacology. Berlin, Germany: Springer; 2011. p. 331–56.
Moreira PI, Santos MS, Moreno AM, Proença T, Seiça R, deOliveira CR. Effect of streptozotocin-induced diabetes on rat brain mitochondria. J Neuroendocrinol. 2004;16(1):32–8.
Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, Perry G. Oxidative Damage and Alzheimer’s disease: are antioxidant therapies useful? Drug News Perspect. 2005;18:13–9.
Nakamura T, Lipton SA. Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding. Cell Death Diff. 2007;14(7):1305–14.
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol. 2001;60:759–67.
Ola MS, Aleisa AM, Al-Rejaie SS, et al. Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats. Neurol Sci. 2014;35(7):1003–8.
Ortiz-Avila O, Sámano-García CA, Calderón-Cortés E, et al. Dietary avocado oil supplementation attenuates the alterations induced by type I diabetes and oxidative stress in electron transfer at the complex II-complex III segment of the electron transport chain in rat kidney mitochondria. J Bioenerg Biomembr. 2013;45(3):271–87.
Ortiz-Avila O, Esquivel-Martínez M, Olmos-Orizaba BE, Saavedra-Molina A, Rodriguez-Orozco AR, Cortés-Rojo C. Avocado oil improves mitochondrial function and decreases oxidative stress in brain of diabetic rats. J Diabetes Res. 2015;2015:485759.
Petrozzi L, Lucetti C, Scarpato R, Gambaccini G, Trippi F, Bernardini S, Del Dotto P, Migliore L, Bonuccelli U. Cytogenetic alterations in lymphocytes of Alzheimer’s disease and Parkinson’s disease patients. Neurol Sci. 2002;23 Suppl 2:S97–8.
Raider JI, Schneeman BO. Prevalence of neural tube defects, folate status, and folate fortification of enriched cereal-grain products in the United States. Pediatrics. 2006;117(4):1394–9.
Rainey C, Affleck M, Bretschger K, Roslyn A-S. The California avocado: a new look. Nutr Today. 1994;29:23–7.
Rajput AH. Frequency and cause of Parkinson’s disease. Can J Neurol Sci. 1992;19(1 Suppl):103–7.
Salganik RI. The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr. 2001;20(Suppl):464S–72.
Scott JM. Evidence of folic acid and folate in the prevention of neural tube defects. Bib Nutr Diet. 2001;55:192–5.
Selvam AB. Inventory of vegetable crude drug samples housed in the botanical survey of India, Howrah. Pharmacogn Rev. 2008;2:61–94.
Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med. 2002;346(7):476–83.
St. George-Hyslop PH. Piecing together Alzheimer’s. Sci Am. 2000;283:76–83.
Thomas P, O’Callaghan NJ, Fenech M. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer’s disease. Mech Ageing Dev. 2008;129:183–90.
Toth C. Diabetes and neurodegeneration in the brain. In: Zochodne DW, Malik RA, editors. Diabetes and the nervous system, vol. 126 of Handbook of clinical neurology. New York, NY: Elsevier; 2014. p. 489–511.
USDA (U.S. Department of Agriculture). Avocado, almond, pistachio and walnut Composition, Nutrient Data Laboratory. USDA National Nutrient Database for Standard Reference, Release 24. Washington, DC: U.S. Department of Agriculture; 2011.
van Rensburg SJ, van Zyl JM, Potocnik FC, Daniels WM, Uys J, Marais L, Hon D, van der Walt BJ, Erasmus RT. The effect of stress on the antioxidative potential of serum: implications for Alzheimer’s disease. Metab Brain Dis. 2006;21:171–9.
Vincent AM, McLean LL, Backus C, Feldman EL. Short-term hyperglycemia produces oxidative damage and apoptosis in neurons. FASEB J. 2005;19(6):638–40.
Von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci. 2009;908:99–110.
Walker JG, Batterham PJ, Mackinnon AJ, Jorm AF, Hickie I, Fenech M, et al. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms—the Beyond Ageing Project: a randomized controlled trial. Am J Clin Nutr. 2012;95(1):194–203.
Wilson RD, Johnson JA, Wyatt P, Allen V, Gagnon A, Langlois S, et al. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can. 2007;29(12):1003–26.
Winner B, Kohl Z, Gage FH. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci. 2011;33(6):1139–51.
Yasir M, Das S, Kharya MD. The phytochemical and pharmacological profile of Persea americana Mill. Pharmacogn Rev. 2010;4(7):77–84.
Yehuda S, Rabinovitz S, Carasso RL. The role of polyunsaturated fatty acids in restoring the aging neuronal membrane. Neurobiol Aging. 2002;23:843–53.
Youdim MBH, Lavie L. Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson’s disease. Life Sci. 1994;55:2077–82.
Young LC, Petersen MR, Sigurdson AJ, Sampson LA, Ward EM, Sampson LA. High density antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots. Am J Clin Nutr. 2009;90:1402–10.
Yun-Zhong F, Sheng Y, Guoyao W. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18:872–9.
Zheng M, Storz G. Redox sensing by prokaryotic transcription factors. Biochem Pharmacol. 2000;59:1–6.
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Ameer, K. (2016). Avocado as a Major Dietary Source of Antioxidants and Its Preventive Role in Neurodegenerative Diseases. In: Essa, M., Akbar, M., Guillemin, G. (eds) The Benefits of Natural Products for Neurodegenerative Diseases. Advances in Neurobiology, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-28383-8_18
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