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New Weapons to Control Bacterial Growth pp 453–487Cite as

The Use of Nanoparticles for Antimicrobial Delivery

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Abstract

Many currently used antibiotics suffer from some drawbacks such as local and systemic side effects, inadequate therapeutic index, and high antimicrobial resistance to bacteria. Since the emergence of multidrug-resistant bacteria, new antibiotic approaches are required. In recent years, nanotechnology has appeared as a successful tool for the encapsulation of antibiotics into nanoparticles (NPs) aiming to treat bacterial infections and overcoming, at the same time, some of the limitations of traditional antimicrobial therapeutics. Drug delivery systems (DDS) provide several advantages over the free drug such as protection from environmental inactivation and specific target site that can lead to an improvement in the treatment of such diseases. Moreover, NPs can overcome tissue and cellular barriers, thereby can treat infections caused by intracellular microorganisms. NPs are capable of reducing drug dose and toxicity as well as dosing frequency which improve patient compliance. Many nanostructures including liposomes, nanoparticles, or dendrimers have demonstrated their ability to increase the therapeutic efficacy of antibiotics and fight against infectious diseases. In this chapter we provide an overview of the current progress of the latest nanosystems developed to delivery antibiotics to combat microbial infection.

María Moreno-Sastre, Marta Pastor equally contributed to the chapter.

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Authors and Affiliations

  1. Laboratory of Pharmaceutics, NanoBioCel Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006, Vitoria-Gasteiz, Spain

    María Moreno-Sastre, Marta Pastor, Amaia Esquisabel & José Luis Pedraz

  2. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain

    María Moreno-Sastre, Marta Pastor, Amaia Esquisabel & José Luis Pedraz

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  1. María Moreno-Sastre
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  2. Marta Pastor
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  3. Amaia Esquisabel
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  4. José Luis Pedraz
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Correspondence to José Luis Pedraz .

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Editors and Affiliations

  1. Faculty of Pharmacy, University of Santiago de Compostel, Santiago de Compostela, Spain

    Tomas G. Villa

  2. Faculty of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain

    Miguel Vinas

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Moreno-Sastre, M., Pastor, M., Esquisabel, A., Pedraz, J.L. (2016). The Use of Nanoparticles for Antimicrobial Delivery. In: Villa, T., Vinas, M. (eds) New Weapons to Control Bacterial Growth. Springer, Cham. https://doi.org/10.1007/978-3-319-28368-5_17

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