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Radiobiology of Glioblastoma pp 209–224Cite as

Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Tumor cell death is the final goal of both radio- and chemotherapy. For several decades, apoptosis has been considered as the principal type of programmed cell death (PCD) in mammalian tissues. Resistance to apoptosis was closely linked to tumorigenesis, and has taken a central position in cell death research. However, in the last years it has become evident that radiotherapy as well as other therapeutic agents, including temozolomide (TMZ) are able to elicit non-apoptotic pathways of PCD, which are not always mutually exclusive, as thought in the past.In this chapter we will address this topic, focusing on apoptosis and autophagy-related cell death in cancer, their induction by IR and TMZ, and implication in glioblastoma (GB) treatment.We will review currently known mechanisms of both IR and TMZ in inducing cell death, the possibility to modulate PCD as well as other approaches which will open new perspectives for improving the efficacy of therapy in GB.

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Authors and Affiliations

  1. Tuscany Tumor Institute, Florence, Italy

    Marzia Toscano & Paolo Tini

  2. Unit of Radiation Oncology, Department of Medicine, Surgery and Neurosciences University of Siena, Siena, Italy

    Marzia Toscano & Silvia Palumbo

  3. Unit of Radiation Oncology, University Hospital of Siena (Azienda Ospedaliera-Universitaria Senese), Viale Bracci 11, Siena, 53100, Italy

    Paolo Tini

  4. Unit of Pathological Anatomy, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy

    Clelia Miracco

  5. Department of Radiological, Oncological and Anatomo-Pathological Sciences, University of Rome “La Sapienza”, Rome, Italy

    Giovanni Luca Gravina

  6. Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

    Sergio Comincini

Authors
  1. Marzia Toscano
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  2. Silvia Palumbo
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  3. Paolo Tini
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  4. Clelia Miracco
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  5. Giovanni Luca Gravina
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  6. Sergio Comincini
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Corresponding author

Correspondence to Marzia Toscano .

Editor information

Editors and Affiliations

  1. University of Siena, Sec. of Radiation Oncology,Dept. of Med., Siena, Italy

    Luigi Pirtoli

  2. Dept. of Applied Clinical & Biotech Sci., University of L’Aquila, L’Aquila, Italy

    Giovanni Luca Gravina

  3. Department of Biology, Temple University, Philadelphia, Pennsylvania, USA

    Antonio Giordano

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Toscano, M., Palumbo, S., Tini, P., Miracco, C., Gravina, G.L., Comincini, S. (2016). Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide. In: Pirtoli, L., Gravina, G., Giordano, A. (eds) Radiobiology of Glioblastoma. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-28305-0_13

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  • DOI: https://doi.org/10.1007/978-3-319-28305-0_13

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