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The Development of a Stem Cell Therapy for Deafness

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Regenerative Medicine - from Protocol to Patient

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Abstract

Medicine is at the doorstep of a phenomenal revolution, brought about by the advances in the stem cell field and the development of new technologies to engineer cells and tissues into more complex organs. The promise of a true regenerative approach to organ damage and loss of function is closer than ever to becoming a reality. The auditory field is participating in these developments with high expectations. Since the cochlea is an organ of difficult access and with very limited regenerative capacity, conventional therapeutic approaches have failed and, currently, the only treatments available are in the form of hearing aids and cochlear implants. The potential restoration of hearing by the use of exogenous stem cells will offer a solution to a condition that has very limited options. In this chapter, we review the increasing volume of research on this emerging field and discuss the key elements that need to be developed further, in order to translate the basic science into a clinical reality.

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Acknowledgements

This work was supported by grants from the Medical Research Council (MRC), EU (FP7) and Action on Hearing Loss (AoHL) to MR.

Author information

Authors and Affiliations

  1. Centre for Stem Cell Biology and Department of Biomedical Sciences, University of Sheffield, Firth Court Bldg, Western Bank, S10 2TN, Sheffield, UK

    Nopporn Jongkamonwiwat, Leila Abbas, Darrell Barrott, Sarah L. Boddy, A. Sameer Mallick & Marcelo N. Rivolta

Authors
  1. Nopporn Jongkamonwiwat
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  2. Leila Abbas
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  3. Darrell Barrott
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  4. Sarah L. Boddy
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  5. A. Sameer Mallick
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  6. Marcelo N. Rivolta
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Corresponding author

Correspondence to Marcelo N. Rivolta .

Editor information

Editors and Affiliations

  1. KIlinik und Poliklinik für Herzchirurgie, Universitätsmedizin Rostock, Rostock, Mecklenburg-Vorpomm., Germany

    Gustav Steinhoff

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© 2016 Springer International Publishing Switzerland

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Jongkamonwiwat, N., Abbas, L., Barrott, D., Boddy, S.L., Mallick, A.S., Rivolta, M.N. (2016). The Development of a Stem Cell Therapy for Deafness. In: Steinhoff, G. (eds) Regenerative Medicine - from Protocol to Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-28293-0_11

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