Abstract
Cluster of Differentiation 71 protein (CD71), also known as the Transferrin receptor protein 1 (TfR1) is a protein encoded by the TFRC gene located on chromosome 3q29. It is found as a cell surface membrane protein in humans and is essential for iron delivery to the cells. TfR1 expression is up-regulated or down-regulated in response to cell’s iron need. A regulatory protein that regulates the interaction between Transferrin and Transferrin receptor is known as HFE1 and its mutation is thought to increase the risk of Alzheimer Disease. TfR1 knockdown cells have been also found to enhance VEGF production and angiogenesis in vivo. CD71 is used as a marker in breast cancer and has also been linked to many other cancers such as lungs, pancreas, lymph nodes and colon. The gene is currently being explored for its diagnostic and therapeutic opportunities. Currently, CD71 is a new target for the potential treatment of human lymphoma & leukaemia.
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Salajegheh, A. (2016). Cluster of Differentiation 71 (CD71). In: Angiogenesis in Health, Disease and Malignancy. Springer, Cham. https://doi.org/10.1007/978-3-319-28140-7_8
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DOI: https://doi.org/10.1007/978-3-319-28140-7_8
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