Abstract
Adenosine triphosphate-binding cassette (ABC) transmembrane proteins are a family of transporters moving variety of molecules across extracellular and intracellular membranes. Categorized into seven major subfamilies of transporters ABCA to ABCG, mostly involved in lipid transport and homeostasis. ABCA1 and ABCG1 are the two members of this family known to be involved and interactive in the process of angiogenesis and mainly the stability of the circulatory system. ABCA1 acts as the transporter in the process of cholesterol and phospholipid efflux pump forming high density lipoproteins (HDL) and as HDL levels have been correlated with improved cardiovascular health, ABCA1 has an essential role in maintaining the circulatory system. ABCG1 located at intracellular vesicles and endosomes of the cell membrane will promotes cholesterol efflux for removal by mature HDL and macrophages. ABCG1 is accountable for intracellular cholesterol homeostasis with a protective role in the cardiovascular system. There were limited evidence in the relationship between ABCA1 and ABCG1 and cancer. The majority of research of ABC transport in cancer was mainly derived from its role in cholesterol efflux and reverse cholesterol transport.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Apte RS (2013) Inhibition of choroidal neovascularization. US Patent US 20130317090 A1, 28 Nov 2013
Bachmeier BE, Iancu CM, Killian PH, Kronski E, Mirisola V, Angelini G, Jochum M, Nerlich AG, Pfeffer U (2009) Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells. Mol Cancer 8:129. doi:10.1186/1476-4598-8-129
Baldan A, Gomes AV, Ping P, Edwards PA (2008) Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol (Baltimore, MD: 1950) 180(5):3560–3568
Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P (2008) LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134(1):97–111. doi:10.1016/j.cell.2008.04.052
Calkin AC, Tontonoz P (2010) Liver X receptor signaling pathways and atherosclerosis. Arterioscler Thromb Vasc Biol 30(8):1513–1518. doi:10.1161/atvbaha.109.191197
de Jong PT (2006) Age-related macular degeneration. N Engl J Med 355(14):1474–1485. doi:10.1056/NEJMra062326
Duygu Sag CC (2013) ABCG1 as a novel link between cholesterol homeostasis and tumor immunity. J Immunol 190(53):2031
El Roz A, Bard JM, Huvelin JM, Nazih H (2012) LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. Anticancer Res 32(7):3007–3013
Gietl A, Giegling I, Hartmann AM, Schneider B, Schnabel A, Maurer K, Moller HJ, Rujescu D (2007) ABCG1 gene variants in suicidal behavior and aggression-related traits. Eur Neuropsychopharmacol 17(6–7):410–416. doi:10.1016/j.euroneuro.2006.11.004
Kennedy MA, Barrera GC, Nakamura K, Baldan A, Tarr P, Fishbein MC, Frank J, Francone OL, Edwards PA (2005) ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab 1(2):121–131. doi:10.1016/j.cmet.2005.01.002
Lee C-H, Plutzky J (2006) Liver X receptor activation and high-density lipoprotein biology: a reversal of fortune? Circulation 113(1):5–8. doi:10.1161/circulationaha.105.590273
Lou J, Zhou H, Li C, Hu L, Lu X, Li J, Yao H, Li W, Zhang X, Xu M (2014) ABCA1 and ABCG1 expression in the small intestine of type 2 diabetic rats. Lab Med 45(1):17–24
Mauldin JP (2009) Macrophage ABCG1 expression and regulation in type 2 diabetes. ASSAY Drug Dev Technol 7(1):101
Mauldin JP, Srinivasan S, Mulya A, Gebre A, Parks JS, Daugherty A, Hedrick CC (2006) Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem 281(30):21216–21224. doi:10.1074/jbc.M510952200
Miroshnikova VV, Demina EP, Mayorov NV, Davydenko VV, Kurjanov PS, Vavilov VN, Vinogradov AG, Denisenko AD, Schwarzman AL (2014) The expression of ABCG1 transporter gene in peripheral blood mononuclear cells of patients with atherosclerosis. Cell Tissue Biol 8(4):337–343. doi:10.1134/s1990519x14040063
Ordovas JM (2000) ABC1: the gene for Tangier disease and beyond. Nutr Rev 58(3 Pt 1):76–79
Out R, Hoekstra M, Meurs I, de Vos P, Kuiper J, Van Eck M, Van Berkel T (2007) Po2-44 Abcg1 protects against atherosclerotic lesion development. Atheroscler Suppl 8(1):29. doi:10.1016/s1567-5688(07)71054-1
Sahebzamani FM, D’Aoust RF, Friedrich D, Aiyer AN, Reis SE, Kip KE (2013) Relationship among low cholesterol levels, depressive symptoms, aggression, hostility, and cynicism. J Clin Lipidol 7(3):208–216. doi:10.1016/j.jacl.2013.01.004
Santamarina-Fojo S, Peterson K, Qiu Y, Freeman L, Cheng J-F, Osorio J, Remaley A, Yang X-P, Haudenschild C, Prades C, Chimini G, Blackmon E, Francois T, Duverger N, Rubin EM, Rosier M, Denèfle P, Fredrickson DS, Brewer HBJ (2000) Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette a promoter. Proc Natl Acad Sci U S A 97(14):7987–7992
Sturek JM, Castle JD, Trace AP, Page LC, Castle AM, Evans-Molina C, Parks JS, Mirmira RG, Hedrick CC (2010) An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. J Clin Invest 120(7):2575–2589. doi:10.1172/jci41280
Tarling EJ (2013) Expanding roles of ABCG1 and sterol transport. Curr Opin Lipidol 24(2):138–146. doi:10.1097/MOL.0b013e32835da122
Tarling EJ, Edwards PA (2011) ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci 108(49):19719–19724. doi:10.1073/pnas.1113021108
Wagner EM, Basso F, Kim CS, Amar MJA (2014) ABC lipid transporters. In: AccessScience. McGraw-Hill Education. http://dx.doi.org/10.1036/1097-8542.801530. Accessed 15 Sept 2015
Yokoyama S (2006) ABCA1 and biogenesis of HDL. J Atheroscler Thromb 13(1):1–15
Yvan-Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, Li R, Welch C, Tall AR (2007) Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 117(12):3900–3908. doi:10.1172/jci33372
Yvan-Charvet L, Wang N, Tall AR (2010) Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol 30(2):139–143. doi:10.1161/atvbaha.108.179283
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Salajegheh, A. (2016). Adenosine Triphosphate-Binding Cassette (ABC) Lipid Transporters. In: Angiogenesis in Health, Disease and Malignancy. Springer, Cham. https://doi.org/10.1007/978-3-319-28140-7_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-28140-7_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28138-4
Online ISBN: 978-3-319-28140-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)