Abstract
The ephrin receptor family and their ligands, the ephrins, are vital for numerous developmental events and the maintenance of organism function. Specifically, the ephrin family mediates embryonic growth processes such as axon guidance, boundary formation and cell migration. While during adulthood, the key targets comprise nervous system function including potentiation, central and peripheral stem cell differentiation and angiogenesis. Ephrin-B2 is a transmembrane, receptor tyrosine kinase that is transcribed by the EFNB2 gene in humans. Binding of Ephrin-B2 is important for cellular adhesion, migration and repulsion for adequate development of the vasculature, epithelium and neural system. Eph-B4 is a protein encoded by the EphB4 gene in humans and is implicated in blood vessel development, morphogenesis, remodelling and permeability. Ephrin-B2 and EphB4 binding are one of the more heavily studied interactions with regards to angiogenesis.
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Salajegheh, A. (2016). Erythropoietin-Producing Hepatocellular Receptors B: Ephrin B2, Ephrin B4. In: Angiogenesis in Health, Disease and Malignancy. Springer, Cham. https://doi.org/10.1007/978-3-319-28140-7_15
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DOI: https://doi.org/10.1007/978-3-319-28140-7_15
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