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Overview of IL-17 Family

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Targeting the IL-17 Pathway in Inflammatory Disorders

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Abstract

The name of IL-17 was first proposed by Yao et al. [1] in 1995 when they discovered that an open reading frame of the T lymphotropic herpesvirus saimiri gene 13 (HSV13) exhibits 58 % homology with a previously cloned molecule, mouse cytotoxic T lymphocyte-associated protein 8 (CTLA-8) [2]. Recombinant HVS13 and CTLA-8 stimulate transcription factor NFκB activity and IL-6 secretion in fibroblasts and co-stimulate T cell proliferation. A novel cytokine receptor was also isolated and shown to bind both HVS13 and CTLA-8. Therefore, mouse CTLA-8 was named as IL-17, HVS13 as viral IL-17, and the newly cloned cytokine receptor as IL-17 receptor (IL-17R) [1]. Human IL-17 shares 72 % homology with HSV13 and 62 % with mouse IL-17 [3]. Subsequently, by homology-based cloning another 5 cytokines were identified to belong to the IL-17 gene family [4, 5, 6, 7]. The prototypic member IL-17 was renamed as IL-17A and the others as IL-17B through to F (see Table 2.1) [8].

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Authors and Affiliations

  1. VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon, USA

    Cong-Qiu Chu

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Chu, CQ. (2017). Overview of IL-17 Family. In: Targeting the IL-17 Pathway in Inflammatory Disorders. Adis, Cham. https://doi.org/10.1007/978-3-319-28040-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-28040-0_1

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  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-28039-4

  • Online ISBN: 978-3-319-28040-0

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