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Traumatic Brain Injury and Growth Hormone Deficiency

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Growth Hormone Deficiency

Abstract

The most common isolated hormonal deficiency after traumatic brain injury (TBI) in both children and adults is growth hormone deficiency (GHD). Adequate evaluation of the growth hormone (GH) axis after TBI in children and adults is evolving. Despite the inherent limitations to this field of research, available data depict the importance of evaluating TBI patients for GHD. GHD affects not only linear growth, but may influence patients’ overall well-being, general metabolism, and cognition as manifested clinically through symptoms such as fatigue and memory problems. Pituitary function after TBI undergoes remarkable variation over time; dissimilar methodologies could account for marked variations in prevalence of GHD. The lack of a gold standard test for GHD raises questions regarding the true occurrence of GHD after TBI. Although somewhat controversial, most recent well-designed studies in children argue in favor of performing dynamic GH tests only in patients with slow growth after appropriate follow-up. All patients with documented severe GHD are candidates for GH replacement therapy.

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Correspondence to Alan D. Rogol .

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© 2016 Springer International Publishing Switzerland

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Richmond, E., Rogol, A.D. (2016). Traumatic Brain Injury and Growth Hormone Deficiency. In: Cohen, L. (eds) Growth Hormone Deficiency. Springer, Cham. https://doi.org/10.1007/978-3-319-28038-7_14

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  • DOI: https://doi.org/10.1007/978-3-319-28038-7_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28036-3

  • Online ISBN: 978-3-319-28038-7

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