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Platelets and Lipoxygenases

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Lipoxygenases in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Platelets are a cellular component of blood whose primary function is to maintain hemostasis in response to vessel insult. Beyond their traditional role in hemostasis, platelets are also known to regulate inflammation. These small anucleated cells express a single lipoxygenase, platelet 12(S)-LOX, which is capable of oxidizing a number of fatty acids. Depending on the fatty acid, the metabolite(s) produced by 12(S)-LOX have often been shown to impact platelet and vessel function in distinct ways and therefore are important regulators of platelet reactivity and inflammation. This chapter reviews the roles of 12(S)-LOX and its metabolites on platelet functions in thrombosis, hemostasis and inflammation.

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Authors and Affiliations

  1. University of Michigan Medical School, 1150 West Medical Center Drive, 2240 Medical Sciences Research Building III (MSRB III), Ann Arbor, MI, 48109-5632, USA

    Michael Holinstat, Katrin Niisuke & Benjamin E. Tourdot

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  1. Michael Holinstat
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  2. Katrin Niisuke
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  3. Benjamin E. Tourdot
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Correspondence to Michael Holinstat .

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  1. Goethe University Frankfurt, Institute of Pharmaceutical Chemistry, Frankfurt, Germany

    Dieter Steinhilber

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© 2016 Springer International Publishing Switzerland

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Holinstat, M., Niisuke, K., Tourdot, B.E. (2016). Platelets and Lipoxygenases. In: Steinhilber, D. (eds) Lipoxygenases in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-27766-0_5

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  • DOI: https://doi.org/10.1007/978-3-319-27766-0_5

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  • Print ISBN: 978-3-319-27764-6

  • Online ISBN: 978-3-319-27766-0

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