Protein metabolism is a core part of metabolism in particular in critical illness. Overall the critically ill subject has an elevated protein turnover to meet the demand associated with critical illness. Regulating mechanisms are incompletely understood, which make recommendations on nutrition support or other therapeutic efforts difficult. The alterations of protein metabolism in critical illness are not uniform between individual tissues, which make global nutrition protocols difficult to evaluate. Recent advances in isotopic techniques to assess protein turnovers in the whole body as well as in individual tissues or even proteins together with advances in imaging will give opportunities to better understand the mechanisms and consequently give more evidence-based recommendation over optimal care.
KeywordsCritical Illness Lean Body Mass Protein Metabolism Synthesis Rate Label Amino Acid
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