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Introduction, Demographics, and Epidemiology of Diabetes

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The Surgical Management of the Diabetic Foot and Ankle

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Abstract

Diabetes mellitus, a leading cause of mortality, is a complex condition caused by uncontrolled hyperglycemia. A diabetes diagnosis increases the risk of developing additional comorbidities, including cardiovascular disease, nephropathy, retinopathy, mental health disorders, and neuropathies. The rate of new diabetes diagnoses in the United States has not significantly changed since 2006, according to the Centers for Disease Control and Prevention; however, the International Diabetes Federation (IDF) estimates that prevalence of diabetes will increase by 53 % worldwide between 2014 and 2035, growing from approximately 387 million people to 592 million affected. Africa, Middle East/North Africa, and South East Asia will be most impacted by 2035, with estimated increases of 93 %, 85 %, and 64 % people affected by diabetes in each region, respectively. While the international cost of diabetes was $612 billion of all healthcare expenses by health systems and patients in 2014, the IDF expects this figure to increase to approximately $627 billion by 2035. Epidemiological studies have analyzed the diabetic population demographically, to assess factors such as age, sex, race/ethnicity, socioeconomic status, and environment in diabetes development. Although the polymorphisms of the disease, Type I diabetes and Type II diabetes, are commonly known, many variants of diabetes exist. Numerous etiologies of diabetes, such as infection, chemical exposure, and genetic defects, have been identified, although some causes remain unknown. Epigenetic-, gene-, and genome-wide association-based studies have continued to investigate multifactorial linkages between the human genome and development of diabetes.

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References

  1. Centers for Disease Control Prevention. National Diabetes Statistics Report: estimates of diabetes and its burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014.

    Google Scholar 

  2. Blas E, Kurup AS. Equity, social determinants and public health programmes. Geneva: World Health Organization; 2010.

    Google Scholar 

  3. Nichols GA, Schroeder EB, Karter AJ, Gregg EW, Desai J, Lawrence JM, et al. Trends in diabetes incidence among 7 million insured adults, 2006–2011: the SUPREME-DM project. Am J Epidemiol. 2015;181(1):32–9.

    Article  PubMed  PubMed Central  Google Scholar 

  4. American Diabetes Association. Economic costs of diabetes in the U.S. in 2012. Diabetes Care. 2013;36(4):1033–46.

    Article  PubMed Central  Google Scholar 

  5. International Diabetes Federation. IDF diabetes atlas. 6th ed. Brussels, Belgium: International Diabetes Federation; 2013.

    Google Scholar 

  6. Center for Disease Control and Prevention. Age-adjusted rate per 100 of civilian, noninstitutionalized population with diagnosed diabetes, by sex, United States, 1980–2011. 2015. http://www.cdc.gov/diabetes/statistics/incidence/fig3.htm. Accessed 8 June 2015.

  7. Huang ZJ, Zheng C. Type 2 diabetes among 6 Asian ethnic groups in California: the nexus of ethnicity, gender, and generational status. J Health Care Poor Underserved. 2015;26(2 Suppl):16–35.

    Article  PubMed  Google Scholar 

  8. Triplitt C, Solis-Herrera C, Reasner C, DeFronzo RA, Cersosimo E. Classification of diabetes mellitus. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, editors. Endotext. South Dartmouth, MA: MDText.com, Inc.; 2000.

    Google Scholar 

  9. van Tilburg J, van Haeften TW, Pearson P, Wijmenga C. Defining the genetic contribution of type 2 diabetes mellitus. J Med Genet. 2001;38(9):569–78.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Fujimoto WY, Boyko EJ, Hayashi T, Kahn SE, Leonetti DL, McNeely MJ, et al. Risk factors for type 2 diabetes: lessons learned from Japanese Americans in Seattle. J Diabetes Investig. 2012;3(3):212–24.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Fujimoto WY, Leonetti DL, Bergstrom RW, Kinyoun JL, Stolov WC, Wahl PW. Glucose intolerance and diabetic complications among Japanese-American women. Diabetes Res Clin Pract. 1991;13(1–2):119–29.

    Article  CAS  PubMed  Google Scholar 

  12. Bao XY, Xie C, Yang MS. Association between type 2 diabetes and CDKN2A/B: a meta-analysis study. Mol Biol Rep. 2012;39(2):1609–16.

    Article  CAS  PubMed  Google Scholar 

  13. Haldar SR, Chakrabarty A, Chowdhury S, Haldar A, Sengupta S, Bhattacharyya M. Oxidative stress-related genes in type 2 diabetes: association analysis and their clinical impact. Biochem Genet. 2015;53(4–6):93–119.

    Article  CAS  PubMed  Google Scholar 

  14. Baumann A, Schroder SL, Fink A. How social inequalities impact the course of treatment and care for patients with type 2 diabetes mellitus: study protocol for a qualitative cross-sectional study from the patient’s perspective. BMJ Open. 2015;5(7), e008670.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Hill J, Nielsen M, Fox MH. Understanding the social factors that contribute to diabetes: a means to informing health care and social policies for the chronically ill. Perm J. 2013;17(2):67–72.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Everson SA, Maty SC, Lynch JW, Kaplan GA. Epidemiologic evidence for the relation between socioeconomic status and depression, obesity, and diabetes. J Psychosom Res. 2002;53(4):891–5.

    Article  PubMed  Google Scholar 

  17. Robbins JM, Vaccarino V, Zhang H, Kasl SV. Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey. Am J Public Health. 2001;91(1):76–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Maty SC, Everson-Rose SA, Haan MN, Raghunathan TE, Kaplan GA. Education, income, occupation, and the 34-year incidence (1965–1999) of type 2 diabetes in the Alameda County Study. Int J Epidemiol. 2005;34(6):1274–81.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Levy N, Moynihan V, Nilo A, Singer K, Bernik LS, Etiebet MA, et al. The mobile insulin titration intervention (MITI) for insulin adjustment in an urban, low-income population: randomized controlled trial. J Med Internet Res. 2015;17(7), e180.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Diabetes HbA1c {Poor control}. The U. S. Department of Health and Human Services. http://www.hrsa.gov/quality/toolbox/508pdfs/diabetesmodule.pdf. Accessed July 20th 2015.

  21. Hipp JA, Chalise N. Spatial analysis and correlates of county-level diabetes prevalence, 2009–2010. Prev Chronic Dis. 2015;12, E08.

    PubMed  PubMed Central  Google Scholar 

  22. Dzhambov AM. Long-term noise exposure and the risk for type 2 diabetes: a meta-analysis. Noise Health. 2015;17(74):23–33.

    Article  PubMed  Google Scholar 

  23. Dzhambov A, Dimitrova D. Chronic noise exposure and testosterone deficiency—meta-analysis and meta-regression of experimental studies in rodents. Endokrynol Pol. 2015;66(1):39–46.

    Article  PubMed  Google Scholar 

  24. Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab. 2011;96(8):2341–53.

    Article  CAS  PubMed  Google Scholar 

  25. Hogan P, Dall T, Nikolov P, American DA. Economic costs of diabetes in the US in 2002. Diabetes Care. 2003;26(3):917–32.

    Article  PubMed  Google Scholar 

  26. Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, et al. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2007;30(1):162–72.

    Article  CAS  PubMed  Google Scholar 

  27. Nichols GA, Brown JB. The impact of cardiovascular disease on medical care costs in subjects with and without type 2 diabetes. Diabetes Care. 2002;25(3):482–6.

    Article  PubMed  Google Scholar 

  28. Krolewski AS, Niewczas MA, Skupien J, Gohda T, Smiles A, Eckfeldt JH, et al. Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria. Diabetes Care. 2014;37(1):226–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Garg JP, Bakris GL. Microalbuminuria: marker of vascular dysfunction, risk factor for cardiovascular disease. Vasc Med. 2002;7(1):35–43.

    Article  PubMed  Google Scholar 

  30. Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen G, Clausen P, Scharling H, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation. 2004;110(1):32–5.

    Article  CAS  PubMed  Google Scholar 

  31. American Diabetes Association. Standards of medical care in diabetes—2014. Diabetes Care. 2014;37 Suppl 1:S14–80.

    Article  Google Scholar 

  32. Wang S, Wang Y, Zheng R, Zhao Z, Ma Y. Osteoinductive factor is a novel biomarker for the diagnosis of early diabetic nephropathy. Int J Clin Exp Pathol. 2015;8(3):3110–5.

    PubMed  PubMed Central  Google Scholar 

  33. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, et al. Retinopathy in diabetes. Diabetes Care. 2003;27 Suppl 1:S84–7.

    Google Scholar 

  34. Boulton AJM, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–62.

    Article  PubMed  Google Scholar 

  35. Merashli M, Chowdhury TA, Jawad AS. Musculoskeletal manifestations of diabetes mellitus. QJM. 2015;108(11):853–7.

    Article  CAS  PubMed  Google Scholar 

  36. The Lancet Diabetes & Endocrinology. Poor mental health in diabetes: still a neglected comorbidity. Lancet Diabetes Endocrinol. 2015;3(6):393.

    Article  Google Scholar 

  37. Deschenes SS, Burns RJ, Schmitz N. Associations between diabetes, major depressive disorder and generalized anxiety disorder comorbidity, and disability: findings from the 2012 Canadian Community Health Survey—Mental Health (CCHS-MH). J Psychosom Res. 2015;78(2):137–42.

    Article  PubMed  Google Scholar 

  38. Ali N, Jyotsna VP, Kumar N, Mani K. Prevalence of depression among type 2 diabetes compared to healthy non diabetic controls. J Assoc Physicians India. 2013;61(9):619–21.

    PubMed  Google Scholar 

  39. Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with type 1 diabetes: systematic literature review. Diabet Med. 2006;23(4):445–8.

    Article  CAS  PubMed  Google Scholar 

  40. Nouwen A, Winkley K, Twisk J, Lloyd CE, Peyrot M, Ismail K, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53(12):2480–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24(6):1069–78.

    Article  CAS  PubMed  Google Scholar 

  42. Roy T, Lloyd CE. Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012;142(Suppl):S8–21.

    Article  PubMed  Google Scholar 

  43. Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Pouwer F, Beekman AT, Nijpels G, Dekker JM, Snoek FJ, Kostense PJ, et al. Rates and risks for co-morbid depression in patients with type 2 diabetes mellitus: results from a community-based study. Diabetologia. 2003;46(7):892–8.

    Article  CAS  PubMed  Google Scholar 

  45. Chew BH, Shariff-Ghazali S, Fernandez A. Psychological aspects of diabetes care: effecting behavioral change in patients. World J Diabetes. 2014;5(6):796–808.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Ahmed N. Advanced glycation endproducts—role in pathology of diabetic complications. Diabetes Res Clin Pract. 2005;67(1):3–21.

    Article  CAS  PubMed  Google Scholar 

  47. Kotagal M, Symons RG, Hirsch IB, Umpierrez GE, Dellinger EP, Farrokhi ET, et al. Perioperative hyperglycemia and risk of adverse events among patients with and without diabetes. Ann Surg. 2015;261(1):97–103.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Acott AA, Theus SA, Kim LT. Long-term glucose control and risk of perioperative complications. Am J Surg. 2009;198(5):596–9.

    Article  PubMed  Google Scholar 

  49. Center for Disease Control and Prevention. Annual Number (in Thousands) of new cases of diagnosed diabetes among adults aged 18–79 Years, United States, 1980–2013. 2015. http://www.cdc.gov/diabetes/statistics/incidence/fig3.htm. Accessed 8 June 2015.

    Google Scholar 

  50. Anjana RM, Sudha V, Nair DH, Lakshmipriya N, Deepa M, Pradeepa R, et al. Diabetes in Asian Indians-How much is preventable? Ten-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES-142). Diabetes Res Clin Pract. 2015;109(2):253–61.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Research, William Beaumont Hospital - Royal Oak, 3811 West Thirteen Mile Road, Ste 404, Royal Oak, MI, USA

    Erin A. Baker M.S.

  2. Foot and Ankle Service, Department of Orthopaedic Surgery, William Beaumont Hospital - Royal Oak, 3535 West Thirteen Mile Road, Ste 744, Royal Oak, MI, USA

    Paul T. Fortin M.D.

Authors
  1. Erin A. Baker M.S.
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Correspondence to Paul T. Fortin M.D. .

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Editors and Affiliations

  1. Foot and Ankle/Trauma Service, Tampa General Hospital, Tampa, Florida, USA

    Dolfi Herscovici, Jr.

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Baker, E.A., Fortin, P.T. (2016). Introduction, Demographics, and Epidemiology of Diabetes. In: Herscovici, Jr., D. (eds) The Surgical Management of the Diabetic Foot and Ankle. Springer, Cham. https://doi.org/10.1007/978-3-319-27623-6_1

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  • DOI: https://doi.org/10.1007/978-3-319-27623-6_1

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