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Classical Pharmacodynamics

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Book cover Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Part of the book series: Interdisciplinary Applied Mathematics ((IAM,volume 30 ))

Abstract

Receptors are the most important targets for therapeutic drugs [570]. Therefore, it is important to explore the mechanisms of receptor modulation and drug action in intact in vivo systems. Also, the need for a more mechanism-based approach in pharmacokinetic-dynamic modeling has been increasingly recognized [571, 572]. Hill [573] made the first explicit mathematical model of simulated drug action to account for the time courses and concentration–effect curves obtained when nicotine was used to provoke contraction of the frog rectus abdominis muscle.

The master of the oracle at Delphi does not say anything and does not conceal anything, only hints.

Heraclitus of Ephesus (544–483 BC)

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Notes

  1. 1.

    In the classical pharmacokinetic-pharmacodynamic literature, the effect-site concentration and the effect-site elimination rate constant are denoted by c E and k E0, respectively. Here, the symbols \(y\left (t\right )\) and k y are used instead.

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Authors and Affiliations

  1. Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece

    Panos Macheras

  2. Faculty of Pharmacy, Aix-Marseille University, Marseille, France

    Athanassios Iliadis

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  1. Panos Macheras
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Macheras, P., Iliadis, A. (2016). Classical Pharmacodynamics. In: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics. Interdisciplinary Applied Mathematics, vol 30 . Springer, Cham. https://doi.org/10.1007/978-3-319-27598-7_12

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