Abstract
Spleen is involved in approximately one third of patients with non-Hodgkin lymphoma (NHL), usually secondarily, either at presentation or at the time of disease progression. On the contrary, primary splenic lymphoma is rare, comprising only 1 % of all lymphomas, although its incidence is probably underestimated. The definition of primary splenic lymphoma is controversial. Herein, we adopt a less restrictive definition of splenic lymphomas, encompassing cases presenting with splenic involvement and in which the disease may also extend to the bone marrow, blood, and liver without prominent lymphadenopathy. Splenic lymphomas include mainly the following categories: splenic marginal zone lymphoma (SMZL), hairy cell leukemia (HCL), and the provisional entities: HCL variant (HCLv), splenic diffuse red pulp small B-cell lymphoma (SDRPL), primary splenic diffuse large B-cell lymphoma (DLBCL), and Τ-γδ hepatosplenic lymphoma [1].
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References
Isaacson PG, Piris MA, Berger F et al (2008) Splenic B-cell marginal zone lymphoma. In: World Health Organization Classification of Tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC, Lyon, pp 185–187
Ahmann DL, Kiely JM, Harrison EG Jr et al (1966) Malignant lymphoma of the spleen. A review of 49 cases in which the diagnosis was made at splenectomy. Cancer 19:461–469
Karunanithi S, Sharma AP, Shambo Guha R et al (2014) Use of 18F-FDG PET/CT imaging for evaluation of patients with primary splenic lymphoma. Clin N Med 39:772–778
Liu Y (2009) Clinical significance of diffusely increased splenic uptake on FDG-PET. Nucl Med Commun 30:763–769
Matutes E, Oscier D, Montalban C et al (2008) Splenic marginal-zone lymphoma proposals for a revision of diagnosis, staging and therapeutic criteria. Leukemia 22:487–495
Kalpadakis C, Pangalis GA, Angelopoulou MK et al (2013) Treatment of splenic marginal zone lymphoma with rituximab: progress report and comparison with splenectomy. Oncologist 18:190–197
Yiakoumis X, Moschogiannis M, Vassilakopoulos T et al (2011) FDG PET CT scan role on diagnosis and initial staging of lymphoproliferative diseases. Haematologica 96:574 (Abstract)
Subhawong AP, Subhawong TK, Ali SZ (2012) Hairy cell leukemia presenting as a peripancreatic mass: cytomorphology and radiographic correlates. Acta Cytol 56:463–466
Rutherford SC, Andemariam B, Philips SM et al (2008) FDG-PET in prediction of splenectomy findings in patients with known or suspected lymphoma. Leuk Lymphoma 49:719–726
Mollejo M, Algara P, Mateo MS et al (2003) Large B-cell lymphoma presenting in the spleen: identification of different clinicopathologic conditions. Am J Surg Pathol 27:895–902
Cheson BD, Fisher RI, Barrington SF et al (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32:3059–3067
Dupuis J, Itti E, Rahmouni A, Hemery F et al (2009) Response assessment after an inductive CHOP or CHOP-like regimen with or without rituximab in 103 patients with diffuse large B-cell lymphoma: integrating 18 fluorodeoxyglucose positron emission tomography to the International Workshop Criteria. Ann Oncol 20:503–507
Thomas A, Gingrich RD, Smith BJ et al (2010) 18-fluoro-deoxyglucose positron emission tomography report interpretation as predictor of outcome in diffuse large B-cell lymphoma including analysis of “indeterminate” reports. Leuk Lymphoma 51:439–446
Pangalis GA, Vassilakopoulos TP, Dimopoulou MN et al (2002) Chronic lymphocytic leukemia: practical aspects. Hematol Oncol 20:103–146
Bruzzi JF, Macapinlac H, Tsimberidou AM et al (2006) Detection of Richter’s transformation of chronic lymphocytic leukemia by PET/CT. J Nucl Med 47:1267–1273
Falchi L, Keating MJ, Marom EM et al (2014) Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia. Blood 123:2783–2790
Papajík T, Mysliveček M, Urbanová R et al (2014) 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography examination in patients with chronic lymphocytic leukemia may reveal Richter transformation. Leuk Lymphoma 55:314–319
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Kalpadakis, C., Pangalis, G.A., Kechagias, D.T., Yiakoumis, X., Vlachou, F.J. (2016). Splenic Lymphomas. In: Andreou, J., Kosmidis, P., Gouliamos, A. (eds) PET/CT in Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-27380-8_12
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DOI: https://doi.org/10.1007/978-3-319-27380-8_12
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