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Management of Pancreatic Gastrinoma

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Difficult Decisions in Hepatobiliary and Pancreatic Surgery

Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY))

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Abstract

Pancreatic gastrinoma is a functional pancreatic neuroendocrine tumor that secretes gastrin and leads to Zollinger-Ellison Syndrome (ZES), a disorder characterized by hypergastrinemia and gastric acid hypersecretion. These tumors may be either sporadic or part of multiple endocrine neoplasia type 1 (MEN-1) syndrome. At present, surgical management remains the first-line treatment for cases of sporadic or hereditary gastrinomas while medical therapy is utilized to ameliorate the effects of hypergastrinemia and resultant gastric acid hypersecretion. Together, these approaches improve survival and reduce disease-related complications in these patients. As such, multi-disciplinary, personalized care is critical for optimizing outcomes in these patients.

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Authors and Affiliations

  1. Division of Surgical Oncology and Department of Surgery, Moores Cancer Center, University of California San Diego, UC San Diego Health System, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA

    Shady F. Gad & Jason K. Sicklick

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  1. Shady F. Gad
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  2. Jason K. Sicklick
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Correspondence to Jason K. Sicklick .

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Editors and Affiliations

  1. The University of Chicago, CHICAGO, Illinois, USA

    J. Michael Millis

  2. The University of Chicago, CHICAGO, Illinois, USA

    Jeffrey B. Matthews

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Gad, S.F., Sicklick, J.K. (2016). Management of Pancreatic Gastrinoma. In: Millis, J., Matthews, J. (eds) Difficult Decisions in Hepatobiliary and Pancreatic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-319-27365-5_57

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  • DOI: https://doi.org/10.1007/978-3-319-27365-5_57

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