Skip to main content

Evaluation and Management of Untoward Intraoperative Bleeding

  • Chapter
  • First Online:
Anticoagulation and Hemostasis in Neurosurgery

Abstract

Abnormal or excessive bleeding during neurosurgical procedures could have devastating consequences and requires diligent, expedient workup and management coordinated by the neurosurgeon and anesthesiologist working together. Multiple modalities now exist in order to evaluate the patient’s ability to clot blood, and point of care testing can isolate the problem to platelet dysfunction, coagulation cascade abnormalities, or some other global phenomenon. Hemostatic agents and alterations in hemodynamics may help to reduce this blood loss and allow the surgeon to identify and control the source of bleeding. Blood salvage techniques may be utilized to reduce the amount of allogenic blood products received, and specific diagnostic techniques may also help facilitate hemostasis and direct the administration of medication to help improve platelet function and reduce or inhibit thrombolysis. A systematic and coordinated effort can decrease overall blood loss and minimize associated morbidity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Braun H, Shields P. Local anesthesia: its scientific basis and practical use. Philadelphia: Lea & Febinger; 1914.

    Google Scholar 

  2. Cushing H. Technical methods of performing certain cranial operations. Surg Gynecol Obstet. 1908;6:227–46.

    Google Scholar 

  3. Frazier CH. Remarks upon the surgical aspects of operable tumors of the cerebrum. In: Mills CK, editor. Tumors of the cerebrum, their focal diagnosis, and surgical treatment. Philadelphia: Pennock; 1906.

    Google Scholar 

  4. Walker AE. A history of neurological surgery. New York: Hafner; 1967.

    Google Scholar 

  5. Horsley V. Antiseptic wax. Br Med J. 1892;1:1165.

    Article  PubMed Central  Google Scholar 

  6. Cushing H, Bovie WT. Electro-surgery as an aid to the removal of intracranial tumors. Surg Gynecol Obstet. 1928;47:752–84.

    Google Scholar 

  7. Stangerup SE, Thomsen HK. Histological changes in the nasal mucosa after hot-water irrigation. An animal experimental study. Rhinology. 1996;34:14–7.

    CAS  PubMed  Google Scholar 

  8. Council on Pharmacy and Chemistry. Absorbable Gelatin sponge—new and nonofficial remedies. JAMA. 1947;135:921.

    Article  Google Scholar 

  9. Gerald AG. Update on hemostasis: neurosurgery. Surgery. 2007;142:S55–60.

    Article  PubMed  Google Scholar 

  10. Herndon JH, Grillo HC, Risenborough EJ, et al. Compression of the brain and spinal cord following use of gelfoam. Arch Surg. 1972;104:107.

    Article  CAS  PubMed  Google Scholar 

  11. Friedman J, Whitecloud 3rd TS. Lumbar cauda equina syndrome associated with the use of gelfoam: case report. Spine. 2001;26:E485–7.

    Article  CAS  PubMed  Google Scholar 

  12. Abbot WM, Austen WG. The effectiveness and mechanism of collagen-induced topical hemostasis. Surgery. 1975;78:723–9.

    Google Scholar 

  13. Levy ML, Amar AP. The use of oxidized regenerated cellulose in neurosurgical procedures. Surg Technol Int. 1998;7:467–71.

    CAS  PubMed  Google Scholar 

  14. Tschan CA, Nie M, Schwandt E, et al. Safety and efficacy of microporous polysaccharide hemospheres in neurosurgery. Neurosurgery. 2011;69(1 (Suppl Operative)):49–63.

    Google Scholar 

  15. Arand AG, Sawaya R. Intraoperative chemical hemostasis in neurosurgery. Neurosurgery. 1986;18:223–33.

    Article  CAS  PubMed  Google Scholar 

  16. Lew W, Weaver F. Clinical use of topical thrombin as a surgical hemostat. Biologics. 2008;2(4):593–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Streiff MB, Ness PM. Acquired FV inhibitors: a needless iatrogenic complication of bovine thrombin exposure. Transfusion. 2002;42:18–26.

    Article  PubMed  Google Scholar 

  18. Martinowitz U, Saltz R. Fibrin sealant. Curr Opin Hematol. 1996;3(5):395–402.

    Article  CAS  PubMed  Google Scholar 

  19. Shaffrey CI, Spotnitz WD, Shaffrey ME, et al. Neurosurgical applications of fibrin glue: augmentation of dural closure in 134 patients. Neurosurgery. 1990;26(2):207–10.

    Article  CAS  PubMed  Google Scholar 

  20. Oz MC, Rondinone JF, Shargill NS. FloSeal Matrix: new generation topical hemostatic sealant. J Card Surg. 2003;18:486–93.

    Article  PubMed  Google Scholar 

  21. Sollevi A. Hypotensive anesthesia and blood loss. Acta Anaesthesiol Scand Suppl. 1988;89:39–43.

    Article  CAS  PubMed  Google Scholar 

  22. Fahmy NM. Indications and contraindications for deliberate hypotension with a review of its cardiovascular effects. Int Anesthesiol Clin. 1979;17(1):175–87.

    Article  CAS  PubMed  Google Scholar 

  23. Shapiro HM. Physiology and pharmacologic regulation of cerebral blood flow. In: ASA refresher course in anesthesiology. Philadelphia, Pa: J.B. Lippincott; 1977. p. 161–78.

    Google Scholar 

  24. Pasch T, Huk W. Cerebral complications following induced hypotension. Eur J Anaesthesiol. 1986;3(4):299–312.

    CAS  PubMed  Google Scholar 

  25. Hickey RF, Verrier ED, Baer RW, et al. A canine model of acute coronary artery stenosis: effects of deliberate hypotension. Anesthesiology. 1983;59(3):226–36.

    CAS  PubMed  Google Scholar 

  26. Hartman JC, Kampine JP, Schmeling WT, et al. Steal-prone coronary circulation in chronically instrumented dogs: isoflurane versus adenosine. Anesthesiology. 1991;74(4):744–56.

    Article  CAS  PubMed  Google Scholar 

  27. Knight PR, Lane GA, Hensinger RN, et al. Catecholamine and renin-angiotensin response during hypotensive anesthesia induced by sodium nitroprusside or trimethaphan camsylate. Anesthesiology. 1983;59(3):248–53.

    CAS  PubMed  Google Scholar 

  28. Fukayama H, Ito H, Shimada M, et al. Effects of hypotensive anesthesia on endocrine systems in oral surgery. Anesth Prog. 1989;36(4-5):175–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Dilger JA, Tetzlaff JE, Bell GR, et al. Ischaemic optic neuropathy after spinal fusion. Can J Anaesth. 1998;45(1):63–6.

    Article  CAS  PubMed  Google Scholar 

  30. Scott BH, Seifert FC, Glass PS, et al. Blood use in patients undergoing coronary artery bypass surgery: impact of cardiopulmonary bypass pump, hematocrit, gender, age and body weight. Anesth Analg. 2003;97:958–63.

    Article  PubMed  Google Scholar 

  31. Pierce LR, Gaines A, Varricchio F, et al. Hemolysis and renal failure associated with use of sterile water for injection to dilute 25% human albumin solution. Am J Health Syst Pharm. 1998;55:1057–70.

    CAS  PubMed  Google Scholar 

  32. Boudreaux JP, Bornside GH, Cohn Jr I. Emergency autotransfusion: partial cleansing of bacteria-laden blood by cell washing. J Trauma. 1983;23:31–5.

    Article  CAS  PubMed  Google Scholar 

  33. Waters JH, Tuohy MJ, Hobson DF, et al. Bacterial reduction by cell salvage washing and leukocyte depletion filtration. Anesthesiology. 2003;99:652–5.

    Article  PubMed  Google Scholar 

  34. Bland LA, Villarino ME, Arduino MJ, et al. Bacteriologic and endotoxin analysis of salvaged blood used in autologous transfusions during cardiac operations. J Thorac Cardiovasc Surg. 1992;103:582–8.

    CAS  PubMed  Google Scholar 

  35. Kang Y, Aggarwal S, Pasculle AW, et al. Bacteriologic study of autotransfusion during liver transplantation. Transplant Proc. 1989;21:35–8.

    Google Scholar 

  36. Smith RN, Yaw PB, Glover JL. Autotransfusion of contaminated Intraperitoneal blood: an experimental study. J Trauma. 1978;18:341–4.

    Article  CAS  PubMed  Google Scholar 

  37. Vamvakas EC. Perioperative blood transfusion and cancer recurrence: meta-analysis for explanation. Transfusion. 1995;35:760–8.

    Article  CAS  PubMed  Google Scholar 

  38. Fisher ER, Turnbull Jr RB. Cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinoma. Surg Gynecol Obstet. 1955;100:102–5.

    CAS  PubMed  Google Scholar 

  39. Edelman MJ, Potter P, Mahaffey KG, et al. The potential for reintroduction of tumor cells during intraoperative blood salvage: reduction of risk with use of the RC-400 leukocyte depletion filter. Urology. 1996;47:179–81.

    Article  CAS  PubMed  Google Scholar 

  40. Perseghin P, Vigano M, Rocco G, et al. Effectiveness of leukocyte filters in reducing tumor cell contamination after intraoperative blood salvage in lung cancer patients. Vox Sang. 1997;72:221–4.

    Article  CAS  PubMed  Google Scholar 

  41. Smith DF, Mihm FG, Mefford I. Hypertension after intraoperative autotransfusion in bilateral adrenalectomy for pheochromocytoma. Anesthesiology. 1983;58:182–4.

    Article  CAS  PubMed  Google Scholar 

  42. Cash JD, Gader AMA, De Costa J. The release of plasminogen activator and factor VIII by LVP, AVP, DDAVP, AT III, and OT in man. Br J Haematol. 1984;30:363–4.

    Google Scholar 

  43. Cooney KA, Ginsburg D, Ruggeri ZM. von Willebrand disease. In: Loscalzo J, Schafer AL, editors. Thrombosis and hemorrhage. Boston, MA: Blackwell Scientific Publications; 1994. p. 657–82.

    Google Scholar 

  44. Mannucci PM, Remuzzi G, Pusineri F. Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med. 1983;308:8–12.

    Article  CAS  PubMed  Google Scholar 

  45. Janssens M, Joris J, David JL, et al. High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery. Anesthesiology. 1994;80:23–9.

    Article  CAS  PubMed  Google Scholar 

  46. Levi MM, Vink R, de Jonge E. Management of bleeding disorders by prohemostatic therapy. Int J Hematol. 2002;72 suppl 2:139–44.

    Article  Google Scholar 

  47. Murkin JM, Lux J, Shannon NA, et al. Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations. J Thorac Cardiovasc Surg. 1994;107:554–61.

    CAS  PubMed  Google Scholar 

  48. Tanaka K, Takao M, Yada I. Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery. J Cardiothorac Anesth. 1989;3:181–8.

    Article  CAS  PubMed  Google Scholar 

  49. Davis R, Whittington R. Aprotinin: a review of its pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery. Drugs. 1995;49:954–83.

    Article  CAS  PubMed  Google Scholar 

  50. Rinder CS, Mathew JP, Ringer HM, et al. Modulation of platelet surface adhesion receptors during cardiopulmonary bypass. Anesthesiology. 1991;75:563–70.

    Article  CAS  PubMed  Google Scholar 

  51. Levy JH, Schwieger IM, Zaidan JR, et al. Evaluation of patients at risk for protamine reactions. J Thorac Cardiovasc Surg. 1989;98:200–4.

    CAS  PubMed  Google Scholar 

  52. Stratmann G, Russell IA, Merrick SH. Use of recombinant factor VIIa as a rescue treatment for intractable bleeding following repeat aortic arch repair. Ann Thorac Surg. 2003;76(6):2094–7.

    Article  PubMed  Google Scholar 

  53. Weiss EJ, Bray PF, Tayback M, et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med. 1996;334:1090–4.

    Article  CAS  PubMed  Google Scholar 

  54. Jobes DR, Schwartz AJ, Ellison N, et al. Monitoring heparin anti-coagulation and its neutralization. Ann Thorac Surg. 1981;31(2):161–6.

    Article  CAS  PubMed  Google Scholar 

  55. Gravlee GP, Rogers AT, Dudas LM, et al. Heparin management protocol for cardiopulmonary bypass influences postoperative heparin rebound but not bleeding. Anesthesiology. 1992;76(3):393–401.

    Article  CAS  PubMed  Google Scholar 

  56. Mongan PD, Hosking MP. The role of desmopressin acetate in patients undergoing coronary artery bypass surgery. A controlled clinical trial with thromboelestographic risk stratification. Anesthesiology. 1992;77(1):38–46.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael P. Wemhoff M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Wemhoff, M.P., Jellish, W.S. (2016). Evaluation and Management of Untoward Intraoperative Bleeding. In: Loftus, C. (eds) Anticoagulation and Hemostasis in Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-27327-3_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27327-3_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27325-9

  • Online ISBN: 978-3-319-27327-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics