Abstract
Just like equivalence studies (Chap. 14), noninferiority studies are very popular in modern clinical research, with many treatments at hand, and with new compounds being mostly only slightly different from the old ones. Unlike equivalence studies, noninferiority studies have, instead of two boundaries with an interval of equivalence in between, a single boundary. Noninferiority studies have been criticized for their wide margin of inferiority, making it, virtually, impossible to reject noninferiority. This chapter is to provide a three-step procedure to adequately analyze noninferiority trials.
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Cleophas, T.J., Zwinderman, A.H. (2016). Noninferiority Testing Instead of Null-Hypothesis Testing. In: Clinical Data Analysis on a Pocket Calculator. Springer, Cham. https://doi.org/10.1007/978-3-319-27104-0_15
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DOI: https://doi.org/10.1007/978-3-319-27104-0_15
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-27104-0
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