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Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting

  • Rudolph M. NavariEmail author
Chapter

Abstract

Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is perceived by patients as a major adverse effect of the treatment [1]. The use of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists plus dexamethasone has significantly improved the control of CINV [2]. Recent studies have demonstrated additional improvement in the control of CINV with the use of new agents: palonosetron, a second generation 5-HT3 receptor antagonist [3]; NK-1 receptor antagonists aprepitant, netupitant, and rolapitant [4–6]; and olanzapine, an antipsychotic which blocks multiple neurotransmitters in the central nervous system [7–9].

Keywords

National Comprehensive Cancer Network National Comprehensive Cancer Network Emetogenic Chemotherapy Highly Emetogenic Chemotherapy Moderately Emetogenic Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Cancer Care Program, Central and South AmericaWorld Health OrganizationAtlantaUSA
  2. 2.Student Outreach ClinicIndiana University School of Medicine South BendSouth BendUSA

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