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Introduction

  • Rudolph M. NavariEmail author
Chapter

Abstract

Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is perceived by patients as a major adverse effect of the treatment [1, 2]. Increased risk of CINV is associated with the type of chemotherapy administered (Table 1.1) and specific patient characteristics (Table 1.2) [3]. CINV can result in serious complications, such as weakness, weight loss, electrolyte imbalance, dehydration, or anorexia, and is associated with a variety of complications, including fractures, esophageal tears, decline in behavioral and mental status, and wound dehiscence [1]. Patients who are dehydrated, debilitated, or malnourished, as well as those who have an electrolyte imbalance or those who have recently undergone surgery or radiation therapy, are at greater risk of experiencing serious complications from CINV [1–3].

Keywords

National Comprehensive Cancer Network National Comprehensive Cancer Network Major Adverse Effect Electrolyte Imbalance Emetogenic Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Bloechl-Daum B, Deuson RR, Mavros P et al (2006) Delayed nausea and vomiting continue to reduce patients’ quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment. J Clin Oncol 24:4472–4478CrossRefPubMedGoogle Scholar
  2. 2.
    Cohen L, de Moor CA, Eisenberg P et al (2007) Chemotherapy-induced nausea and vomiting: incidence and impact on patient quality of life at community oncology settings. Support Care Cancer 15(5):497–503CrossRefPubMedGoogle Scholar
  3. 3.
    Navari RM (2009) Pharmacological management of chemotherapy-induced nausea and vomiting: focus on recent developments. Drugs 69:515–533CrossRefPubMedGoogle Scholar
  4. 4.
    Navari RM (2010) Palonosetron for the prevention of chemotherapy-induced nausea and vomiting in patients with cancer. Future Oncol 6:1074–1084CrossRefGoogle Scholar
  5. 5.
    Curran MP, Robinson DM (2009) Aprepitant: a review of its use in the prevention of nausea and vomiting. Drugs 69:1853–1858CrossRefPubMedGoogle Scholar
  6. 6.
    Sankhala KK, Pandya DM, Sarantopoulos J et al (2009) Prevention of chemotherapy induced nausea and vomiting: a focus on aprepitant. Expert Opin Drug Metab Toxicol 12:1607–1614CrossRefGoogle Scholar
  7. 7.
    Navari RM (2015) Profile of netupitant/palonosetron fixed dose combination (NEPA) and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV). Drug Des Dev Ther 9:155–161Google Scholar
  8. 8.
    Navari RM (2015) Rolapitant for the treatment of chemotherapy induced nausea and vomiting. Expert Rev Anticancer Ther 15:1127–1133CrossRefPubMedGoogle Scholar
  9. 9.
    Navari RM, Einhorn LH, Loehrer PJ et al (2007) A phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy-induced nausea and vomiting. Support Care Cancer 15:1285–1291CrossRefPubMedGoogle Scholar
  10. 10.
    Tan L, Liu J, Liu X et al (2009) Clinical research of olanzapine for the prevention of chemotherapy-induced nausea and vomiting. J Exp Clin Cancer Res 28:1–7CrossRefGoogle Scholar
  11. 11.
    Navari RM, Gray SE, Kerr AC (2011) Olanzapine versus aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a randomized phase III trial. J Support Oncol 9:188–195CrossRefPubMedGoogle Scholar
  12. 12.
    Navari RM (2012) Treatment of chemotherapy-induced nausea. Community Oncol 9:20–26CrossRefGoogle Scholar
  13. 13.
    Stern RM, Koch KL, Andrews PLR (eds) (2011) Nausea: mechanisms and management. Oxford University Press, New YorkGoogle Scholar
  14. 14.
    Roila F, Herrstedt J, Aapro M et al (2010) Guideline update for MASCC and ESMO in the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol 21(5):232–243CrossRefGoogle Scholar
  15. 15.
    Basch E, Prestrud AA, Hesketh PJ et al (2011) Antiemetic American Society Clinical Oncology clinical practice guideline update. J Clin Oncol 29:4189–4198CrossRefPubMedGoogle Scholar
  16. 16.
    NCCN Clinical Practice Guidelines in Oncology version 1 2015. Antiemesis. National Comprehensive Cancer Network (NCCN) [online]. Available from URL: http://www.nccn.org/professionals/physician_gls/PDF/antiemesis.pdf. Accessed Oct 2015

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Cancer Care Program, Central and South America, World Health OrganizationIndiana University School of Medicine South BendSouth BendUSA

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