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Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Non-selective Cation Channel

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Calcium Entry Pathways in Non-excitable Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 898))

Abstract

Transient receptor potential canonical subfamily, member 7 (TRPC7) is the most recently identified member of the TRPC family of Ca2+-permeable non-selective cation channels. The gene encoding the TRPC7 channel plasma membrane protein was first cloned from mouse brain. TRPC7 mRNA and protein have been detected in cell types derived from multiple organ systems from various species including humans. Gq-coupled protein receptor activation is the predominant mode of TRPC7 activation. Lipid metabolites involved in the phospholipase C (PLC) signaling pathway, including diacylglycerol (DAG) and its precursor the phosphatidylinositol-4,5-bisphosphate (PIP2), have been shown to be direct regulators of TRPC7 channel. TRPC7 channels have been linked to the regulation of various cellular functions however, the depth of our understanding of TRPC7 channel function and regulation is limited in comparison to other TRP channel family members. This review takes a historical look at our current knowledge of TRPC7 mechanisms of activation and its role in cellular physiology and pathophysiology.

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Authors and Affiliations

  1. Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA

    Xuexin Zhang, Amy M. Spinelli, Timothy Masiello & Mohamed Trebak

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  1. Xuexin Zhang
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  2. Amy M. Spinelli
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Correspondence to Mohamed Trebak .

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  1. Depto. Fisiología, University of Extremadura, Cáceres, Spain

    Juan A. Rosado

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Zhang, X., Spinelli, A.M., Masiello, T., Trebak, M. (2016). Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Non-selective Cation Channel. In: Rosado, J. (eds) Calcium Entry Pathways in Non-excitable Cells. Advances in Experimental Medicine and Biology, vol 898. Springer, Cham. https://doi.org/10.1007/978-3-319-26974-0_11

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