Second Messenger-Operated Calcium Entry Through TRPC6

  • Alexandre BouronEmail author
  • Sylvain Chauvet
  • Stuart Dryer
  • Juan A. Rosado
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 898)


Canonical transient receptor potential 6 (TRPC6) proteins assemble into heteromultimeric structures forming non-selective cation channels. In addition, many TRPC6-interacting proteins have been identified like some enzymes, channels, pumps, cytoskeleton-associated proteins, immunophilins, or cholesterol-binding proteins, indicating that TRPC6 are engaged into macromolecular complexes. Depending on the cell type and the experimental conditions used, TRPC6 activity has been reported to be controlled by diverse modalities. For instance, the second messenger diacylglycerol, store-depletion, the plant extract hyperforin or H2O2 have all been shown to trigger the opening of TRPC6 channels. A well-characterized consequence of TRPC6 activation is the elevation of the cytosolic concentration of Ca2+. This latter response can reflect the entry of Ca2+ through open TRPC6 channels but it can also be due to the Na+/Ca2+ exchanger (operating in its reverse mode) or voltage-gated Ca2+ channels (recruited in response to a TRPC6-mediated depolarization). Although TRPC6 controls a diverse array of biological functions in many tissues and cell types, its pathophysiological functions are far from being fully understood. This chapter covers some key features of TRPC6, with a special emphasis on their biological significance in kidney and blood cells.


TRPC6 Ca2+ entry DAG Kidney Blood cells 



This work was supported by CNRS, l’Agence Nationale de la Recherche (ANR 13-NEUR-0003-02) and MINECO (Grant BFU2013-45564-C2-1-P).


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Alexandre Bouron
    • 1
    • 2
    Email author
  • Sylvain Chauvet
    • 1
    • 2
  • Stuart Dryer
    • 3
    • 4
  • Juan A. Rosado
    • 5
  1. 1.Université Grenoble AlpesGrenobleFrance
  2. 2.CNRS, iRTSV-LCBMGrenobleFrance
  3. 3.University of HoustonHoustonUSA
  4. 4.Baylor College of MedicineHoustonUSA
  5. 5.Departamento de FisiologíaUniversity of ExtremaduraCáceresSpain

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