Odorant Detection by On-line Chemical Ionization Mass Spectrometry

Part of the Springer Handbooks book series (SPRINGERHAND)

Abstract

The nasal olfactory receptors allow us, as human beings, to detect and perceive odors almost instantaneously upon exposure and over a broad range of concentrations down to ultratrace levels. Translating this rapid and sensitive detection of odorant molecules to the analytical laboratory is a challenging, nontrivial endeavor that remains unachieved to date. On-line mass spectrometry based on chemical ionization (CIMS) comprises sophisticated analytical techniques that meet several of the key requirements in odorant detection, namely fast response times and direct analyses, trace level limits of detection, and a high sensitivity to a suite of odors or, more specifically, odorants. This chapter discusses on-line CIMS and its application in odorant detection in selected fields. The prominent CIMS techniques of selected ion flow tube mass spectrometry (SIFT -MS ), proton transfer reaction MS (PTR -MS ) and atmospheric pressure chemical ionization MS (APCI-MS) are considered, commencing with a brief introduction to their historical developments and a discussion of their operational features and suitability for odorant detection, followed by a review of their widespread applications in odorant measurements in diverse fields of study.

ANOVA

analysis of variance

APCI

atmospheric pressure chemical ionization

API-MS

atmospheric pressure ionization mass spectrometry

CCCRC

Connecticut Chemosensory Clinical Research Center test

CI

chemical ionization

CWA

chemical warfare agent

EBC

exhaled breath condensate

EEG

electroencephalography

EI

electron ionization

FDT

flow drift tube

FFI

food freshness indicator

FID

flame ionization detection

fMRI

functional magnetic resonance imaging

FTIR

Fourier transform infrared

FWHM

full-width at half maximum

GC-O

gas chromatography-olfactometry

GC

gas chromatography

IAMS

ion attachment mass spectrometry

IMR

ion-molecule reaction

IMS

ion mobility spectrometry

IT-MS

ion trap mass spectrometry

LC

liquid chromatography

LOD

limit of detection

LOQ

limit of quantitation

LOX

lipoxygenase

MAP

modified atmosphere packaging

MCC

multicapillary column

MS

mass spectrometry

m ∕ z

mass-to-charge ratio

OAV

odor activity value

OBP

odor binding protein

PA

proton affinity

PCA

principal components analysis

PDO

protected designation of origin

PEEK

polyether ether ketone

PID

photoionization detector

ppbv

parts per billion by volume

ppmv

parts per million by volume

pptv

parts per trillion by volume

PTFE

polytetrafluoroethylene

PTR

proton transfer reaction

SESI

secondary electrospray ionization

SID

selected ion detection

SIFDT

selected ion flow drift tube

SIFT

selected ion flow tube

SIM

selected ion monitoring

SOA

secondary organic aerosol

SPME

solid phase micro extraction

TAGA

trace atmospheric gas analyzer

TDS

temporal dominance of sensation

TD

thermal desorption

TIC

toxic industrial compound

TOF

time-of-flight

UPSIT

University of Pennsylvania smell identification test

UV

ultraviolet

VMR

volume mixing ratio

VOC

volatile organic compound

VSC

volatile sulfur compound

Notes

Acknowledgements

The authors would like to thank the following people for supplying material on the main techniques discussed within this chapter, namely Murray McEwan and Vaughan Langford of Syft Technologies Ltd., Christchurch, New Zealand (SIFT-MS), Jens Herbig and Lukas Märk of IONICON Analytik GmbH, Innsbruck, Austria (PTR-MS), Jean-Luc Le Quéré at INRA, Dijon, France, Andy Taylor of Mars Petcare, Waltham on the Wolds, Leicestershire, UK, Robert Linforth at University of Nottingham, Nottingham, UK and Ed Sprake at Waters Corporation, Wilmslow, UK (APCI-MS).

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© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Fraunhofer Institute for Process Engineering and Packaging (IVV)FreisingGermany

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