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Small Bowel Transplantation

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Nutritional Management of Inflammatory Bowel Diseases

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Abstract

Inflammatory bowel disease (IBD), in particular Crohn’s disease (CD), can result in Intestinal Failure (IF) requiring long-term home parenteral nutrition (HPN). Where patients experience life-threatening complications associated with HPN, small bowel intestinal transplantation (SBITx) provides a realistic alternative therapeutic option, but comes with its own set of risks and complications associated with surgery and immunosuppression. This chapter will provide an overview of IF, the indications for SBITx, types of SBITx and outcomes and economic considerations of SBITx pertinent to patients with IBD.

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Abbreviations

CD:

Crohn’s disease

ECF:

Enterocutaneous fistula

HPN:

Home parenteral nutrition

IBD:

Inflammatory bowel disease

IF:

Intestinal failure

IFALD:

IF associated liver disease

PSC:

Primary sclerosing cholangitis

QoL:

Quality of life

UC:

Ulcerative colitis

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Authors and Affiliations

  1. The Translational Gastroenterology Unit, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK

    Philip J. Allan MBBS,B.Sc,DPHIL,MRCP

  2. The Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, OX3 7LE, UK

    Philip J. Allan MBBS,B.Sc,DPHIL,MRCP & Anil Vaidya M.D.

  3. The Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK

    Philip J. Allan MBBS,B.Sc,DPHIL,MRCP & Simon Lal M.B.B.S., Ph.D., F.R.C.P.

Authors
  1. Philip J. Allan MBBS,B.Sc,DPHIL,MRCP
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  2. Anil Vaidya M.D.
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  3. Simon Lal M.B.B.S., Ph.D., F.R.C.P.
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Corresponding author

Correspondence to Philip J. Allan MBBS,B.Sc,DPHIL,MRCP .

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Editors and Affiliations

  1. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Ashwin N. Ananthakrishnan

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Allan, P.J., Vaidya, A., Lal, S. (2016). Small Bowel Transplantation. In: Ananthakrishnan, A. (eds) Nutritional Management of Inflammatory Bowel Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-26890-3_12

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  • DOI: https://doi.org/10.1007/978-3-319-26890-3_12

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