Skip to main content
SpringerLink
Log in

Additional Interventions in EUS

  • Chapter
  • First Online:
Advanced Pancreaticobiliary Endoscopy

  • 978 Accesses

Abstract

The evolution of endoscopic ultrasound (EUS) from a purely diagnostic modality to one with multiple therapeutic applications has revolutionized the field of interventional endoscopy. In this chapter, we describe cutting-edge diagnostic and therapeutic EUS-guided interventions like needle-based confocal laser endomicroscopy (nCLE) and cytobrush sampling of pancreatic cystic lesions, gold fiducial placement, ethanol ablation for pancreatic cystic lesions, coil placement for GI bleeding control, and radiofrequency ablation, to name a few. Only a few of the devices used in these interventions are FDA approved and commercially available in the USA. These interventions appear feasible and are minimally invasive, thus heralding a new era in therapeutic endoscopy using the EUS platform. Further evaluation in animal studies, protocol-based human experience, and subsequent use in the field will ultimately determine the exact role and efficacy of each of these interventions in clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Konda VJ, Meining A, Jamil LH, Giovannini M, Hwang JH, Wallace MB, Chang KJ, Siddiqui UD, Hart J, Lo SK, et al. A pilot study of in vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscopy under endosonographic guidance. Endoscopy. 2013;45(12):1006–13.

    Article  PubMed  Google Scholar 

  2. Levy MJ, Clain JE. Evaluation and management of cystic pancreatic tumors: emphasis on the role of EUS FNA. Clin Gastroenterol Hepatol. 2004;2(8):639–53.

    Article  PubMed  Google Scholar 

  3. Hutchins GF, Draganov PV. Cystic neoplasms of the pancreas: a diagnostic challenge. World J Gastroenterol. 2009;15(1):48–54.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Attasaranya S, Pais S, LeBlanc J, McHenry L, Sherman S, DeWitt JM. Endoscopic ultrasound-guided fine needle aspiration and cyst fluid analysis for pancreatic cysts. JOP. 2007;8(5):553–63.

    PubMed  Google Scholar 

  5. Meining A, Chen YK, Pleskow D, Stevens P, Shah RJ, Chuttani R, Michalek J, Slivka A. Direct visualization of indeterminate pancreaticobiliary strictures with probe-based confocal laser endomicroscopy: a multicenter experience. Gastrointest Endosc. 2011;74(5):961–8.

    Article  PubMed  Google Scholar 

  6. Gaddam S, Mathur SC, Singh M, Arora J, Wani SB, Gupta N, Overhiser A, Rastogi A, Singh V, Desai N, et al. Novel probe-based confocal laser endomicroscopy criteria and interobserver agreement for the detection of dysplasia in Barrett’s esophagus. Am J Gastroenterol. 2011;106(11):1961–9.

    Article  PubMed  Google Scholar 

  7. Giovannini M, Caillol F, Lemaistre A, et al. Endoscopic ultrasound guided confocal microscopy: Atlas of cystic pancreatic lesions. Endosc Ultrasound. 2014;3:S19–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Konda VJ, Aslanian HR, Wallace MB, Siddiqui UD, Hart J, Waxman I. First assessment of needle-based confocal laser endomicroscopy during EUS-FNA procedures of the pancreas (with videos). Gastrointest Endosc. 2011;74(5):1049–60.

    Article  PubMed  Google Scholar 

  9. Nakai Y, Iwashita T, Park DH, Samarasena JB, Lee JG, Chang KJ. Diagnosis of pancreatic cysts: EUS-guided, through-the-needle confocal laser-induced endomicroscopy and cystoscopy trial: DETECT study. Gastrointest Endosc. 2015.

    Google Scholar 

  10. Al-Haddad M, Raimondo M, Woodward T, Krishna M, Pungpapong S, Noh K, Wallace MB. Safety and efficacy of cytology brushings versus standard FNA in evaluating cystic lesions of the pancreas: a pilot study. Gastrointest Endosc. 2007;65(6):894–8.

    Article  PubMed  Google Scholar 

  11. Lozano MD, Subtil JC, Miravalles TL, Echeveste JI, Prieto C, Betes M, Alvarez Cienfuegos FJ, Idoate MA. EchoBrush may be superior to standard EUS-guided FNA in the evaluation of cystic lesions of the pancreas: preliminary experience. Cancer Cytopathol. 2011;119(3):209–14.

    Article  PubMed  Google Scholar 

  12. Al-Haddad M, Gill KR, Raimondo M, Woodward TA, Krishna M, Crook JE, Skarvinko LN, Jamil LH, Hasan M, Wallace MB. Safety and efficacy of cytology brushings versus standard fine-needle aspiration in evaluating cystic pancreatic lesions: a controlled study. Endoscopy. 2010;42(2):127–32.

    Article  CAS  PubMed  Google Scholar 

  13. Al-Haddad M, Eloubeidi MA. Interventional EUS for the diagnosis and treatment of locally advanced pancreatic cancer. JOP. 2010;11(1):1–7.

    PubMed  Google Scholar 

  14. Majumder S, Berzin TM, Mahadevan A, Pawa R, Ellsmere J, Sepe PS, Larosa SA, Pleskow DK, Chuttani R, Sawhney MS. Endoscopic ultrasound-guided pancreatic fiducial placement: how important is ideal fiducial geometry? Pancreas. 2013;42(4):692–5.

    Article  PubMed  Google Scholar 

  15. Davila Fajardo R, Lekkerkerker SJ, van der Horst A, Lens E, Bergman JJ, Fockens P, Bel A, van Hooft JE. EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer. Gastrointest Endosc. 2014;79(5):851–5.

    Article  PubMed  Google Scholar 

  16. Pishvaian AC, Collins B, Gagnon G, Ahlawat S, Haddad NG. EUS-guided fiducial placement for CyberKnife radiotherapy of mediastinal and abdominal malignancies. Gastrointest Endosc. 2006;64(3):412–7.

    Article  PubMed  Google Scholar 

  17. Choi JH, Seo DW, Park do H, Lee SK, Kim MH. Fiducial placement for stereotactic body radiation therapy under only endoscopic ultrasonography guidance in pancreatic and hepatic malignancy: practical feasibility and safety. Gut Liver. 2014;8(1):88–93.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Zhongmin W, Yu L, Fenju L, Kemin C, Gang H. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. Eur Radiol. 2010;20(7):1786–91.

    Article  PubMed  Google Scholar 

  19. Kishi K, Sonomura T, Shirai S, Noda Y, Sato M, Kawai M, Yamaue H. Brachytherapy reirradiation with hyaluronate gel injection of paraaortic lymphnode metastasis of pancreatic cancer: paravertebral approach—a technical report with a case. J Radiat Res. 2011;52(6):840–4.

    Article  PubMed  Google Scholar 

  20. Sun S, Qingjie L, Qiyong G, Mengchun W, Bo Q, Hong X. EUS-guided interstitial brachytherapy of the pancreas: a feasibility study. Gastrointest Endosc. 2005;62(5):775–9.

    Article  PubMed  Google Scholar 

  21. Sun S, Xu H, Xin J, Liu J, Guo Q, Li S. Endoscopic ultrasound-guided interstitial brachytherapy of unresectable pancreatic cancer: results of a pilot trial. Endoscopy. 2006;38(4):399–403.

    Article  CAS  PubMed  Google Scholar 

  22. Jin Z, Du Y, Li Z, Jiang Y, Chen J, Liu Y. Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study. Endoscopy. 2008;40(4):314–20.

    Article  CAS  PubMed  Google Scholar 

  23. Omerovic S, Zerem E. Alcohol sclerotherapy in the treatment of symptomatic simple renal cysts. Bosn J Basic Med Sci. 2008;8(4):337–40.

    PubMed  Google Scholar 

  24. Larssen TB, Jensen DK, Viste A, Horn A. Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts. Long-term results. Acta Radiol. 1999;40(6):636–8.

    Article  CAS  PubMed  Google Scholar 

  25. Livraghi T, Bolondi L, Lazzaroni S, Marin G, Morabito A, Rapaccini GL, Salmi A, Torzilli G. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients. Cancer. 1992;69(4):925–9.

    Article  CAS  PubMed  Google Scholar 

  26. Xiao YY, Tian JL, Li JK, Yang L, Zhang JS. CT-guided percutaneous chemical ablation of adrenal neoplasms. AJR Am J Roentgenol. 2008;190(1):105–10.

    Article  PubMed  Google Scholar 

  27. Bean WJ, Rodan BA. Hepatic cysts: treatment with alcohol. AJR Am J Roentgenol. 1985;144(2):237–41.

    Article  CAS  PubMed  Google Scholar 

  28. Gelczer RK, Charboneau JW, Hussain S, Brown DL. Complications of percutaneous ethanol ablation. J Ultrasound Med. 1998;17(8):531–3.

    CAS  PubMed  Google Scholar 

  29. Goh BK, Tan YM, Cheow PC, Chung YF, Chow PK, Wong WK, Ooi LL. Cystic lesions of the pancreas: an appraisal of an aggressive resectional policy adopted at a single institution during 15 years. Am J Surg. 2006;192(2):148–54.

    Article  PubMed  Google Scholar 

  30. Oh HC, Seo DW. Endoscopic ultrasonography-guided pancreatic cyst ablation (with video). J Hepatobiliary Pancreat Sci. 2015;22(1):16–9.

    Article  PubMed  Google Scholar 

  31. Oh HC, Seo DW, Song TJ, Moon SH, Park do H, Soo Lee S, Lee SK, Kim MH, Kim J. Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts. Gastroenterology. 2011;140(1):172–9.

    Article  CAS  PubMed  Google Scholar 

  32. Gan SI, Thompson CC, Lauwers GY, Bounds BC, Brugge WR. Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc. 2005;61(6):746–52.

    Article  PubMed  Google Scholar 

  33. DeWitt J, McGreevy K, Schmidt CM, Brugge WR. EUS-guided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blind study. Gastrointest Endosc. 2009;70(4):710–23.

    Article  PubMed  Google Scholar 

  34. Oh HC, Seo DW, Lee TY, Kim JY, Lee SS, Lee SK, Kim MH. New treatment for cystic tumors of the pancreas: EUS-guided ethanol lavage with paclitaxel injection. Gastrointest Endosc. 2008;67(4):636–42.

    Article  PubMed  Google Scholar 

  35. DeWitt JM, Al-Haddad M, Sherman S, LeBlanc J, Schmidt CM, Sandrasegaran K, Finkelstein SD. Alterations in cyst fluid genetics following endoscopic ultrasound-guided pancreatic cyst ablation with ethanol and paclitaxel. Endoscopy. 2014;46(6):457–64.

    Article  PubMed  Google Scholar 

  36. DeWitt J. Endoscopic ultrasound-guided pancreatic cyst ablation. Gastrointest Endosc Clin N Am. 2012;22(2):291–302. ix-x.

    Article  PubMed  Google Scholar 

  37. Khashab MA, Shin EJ, Amateau S, Canto MI, Hruban RH, Fishman EK, Cameron JL, Edil BH, Wolfgang CL, Schulick RD, et al. Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms. Am J Gastroenterol. 2011;106(8):1521–6.

    Article  PubMed  Google Scholar 

  38. Jurgensen C, Schuppan D, Neser F, Ernstberger J, Junghans U, Stolzel U. EUS-guided alcohol ablation of an insulinoma. Gastrointest Endosc. 2006;63(7):1059–62.

    Article  PubMed  Google Scholar 

  39. Gunter E, Lingenfelser T, Eitelbach F, Muller H, Ell C. EUS-guided ethanol injection for treatment of a GI stromal tumor. Gastrointest Endosc. 2003;57(1):113–5.

    Article  PubMed  Google Scholar 

  40. Artifon EL, Lucon AM, Sakai P, Gerhardt R, Srougi M, Takagaki T, Ishioka S, Bhutani MS. EUS-guided alcohol ablation of left adrenal metastasis from non-small-cell lung carcinoma. Gastrointest Endosc. 2007;66(6):1201–5.

    Article  PubMed  Google Scholar 

  41. Barclay RL, Perez-Miranda M, Giovannini M. EUS-guided treatment of a solid hepatic metastasis. Gastrointest Endosc. 2002;55(2):266–70.

    Article  PubMed  Google Scholar 

  42. DeWitt J, Mohamadnejad M. EUS-guided alcohol ablation of metastatic pelvic lymph nodes after endoscopic resection of polypoid rectal cancer: the need for long-term surveillance. Gastrointest Endosc. 2011;74(2):446–7.

    Article  PubMed  Google Scholar 

  43. Soehendra N, Nam VC, Grimm H, Kempeneers I. Endoscopic obliteration of large esophagogastric varices with bucrylate. Endoscopy. 1986;18(1):25–6.

    Article  CAS  PubMed  Google Scholar 

  44. Garcia-Tsao G, Sanyal AJ, Grace ND, Carey WD, Practice Guidelines Committee of American Association for Study of Liver D, Practice Parameters Committee of American College of G. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am J Gastroenterol. 2007;102(9):2086–102.

    Article  PubMed  Google Scholar 

  45. de Franchis R, Baveno VF. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53(4):762–8.

    Article  PubMed  Google Scholar 

  46. Irani S, Kowdley K, Kozarek R. Gastric varices: an updated review of management. J Clin Gastroenterol. 2011;45(2):133–48.

    Article  PubMed  Google Scholar 

  47. Binmoeller KF, Weilert F, Shah JN, Kim J. EUS-guided transesophageal treatment of gastric fundal varices with combined coiling and cyanoacrylate glue injection (with videos). Gastrointest Endosc. 2011;74(5):1019–25.

    Article  PubMed  Google Scholar 

  48. Lee YT, Chan FK, Ng EK, Leung VK, Law KB, Yung MY, Chung SC, Sung JJ. EUS-guided injection of cyanoacrylate for bleeding gastric varices. Gastrointest Endosc. 2000;52(2):168–74.

    Article  CAS  PubMed  Google Scholar 

  49. Romero-Castro R, Pellicer-Bautista FJ, Jimenez-Saenz M, Marcos-Sanchez F, Caunedo-Alvarez A, Ortiz-Moyano C, Gomez-Parra M, Herrerias-Gutierrez JM. EUS-guided injection of cyanoacrylate in perforating feeding veins in gastric varices: results in 5 cases. Gastrointest Endosc. 2007;66(2):402–7.

    Article  PubMed  Google Scholar 

  50. Levy MJ, Wong Kee Song LM, Kendrick ML, Misra S, Gostout CJ. EUS-guided coil embolization for refractory ectopic variceal bleeding (with videos). Gastrointest Endosc. 2008;67(3):572–4.

    Article  PubMed  Google Scholar 

  51. Puri R, Eloubeidi MA, Sud R, Kumar M, Jain P. Endoscopic ultrasound-guided drainage of pelvic abscess without fluoroscopy guidance. J Gastroenterol Hepatol. 2010;25(8):1416–9.

    Article  PubMed  Google Scholar 

  52. Ulla-Rocha JL, Vilar-Cao Z, Sardina-Ferreiro R. EUS-guided drainage and stent placement for postoperative intra-abdominal and pelvic fluid collections in oncological surgery. Therap Adv Gastroenterol. 2012;5(2):95–102.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Trevino JM, Drelichman ER, Varadarajulu S. Modified technique for EUS-guided drainage of pelvic abscess (with video). Gastrointest Endosc. 2008;68(6):1215–9.

    Article  PubMed  Google Scholar 

  54. Giovannini M, Bories E, Moutardier V, Pesenti C, Guillemin A, Lelong B, Delpero JR. Drainage of deep pelvic abscesses using therapeutic echo endoscopy. Endoscopy. 2003;35(6):511–4.

    Article  CAS  PubMed  Google Scholar 

  55. Varadarajulu S, Drelichman ER. Effectiveness of EUS in drainage of pelvic abscesses in 25 consecutive patients (with video). Gastrointest Endosc. 2009;70(6):1121–7.

    Article  PubMed  Google Scholar 

  56. Jang JW, Lee SS, Song TJ, Hyun YS, Park do H, Seo DW, Lee SK, Kim MH, Yun SC. Endoscopic ultrasound-guided transmural and percutaneous transhepatic gallbladder drainage are comparable for acute cholecystitis. Gastroenterology. 2012;142(4):805–11.

    Article  PubMed  Google Scholar 

  57. Hasan MK, Itoi T, Varadarajulu S. Endoscopic management of acute cholecystitis. Gastrointest Endosc Clin N Am. 2013;23(2):453–9.

    Article  PubMed  Google Scholar 

  58. Choi JH, Lee SS, Choi JH, Park do H, Seo DW, Lee SK, Kim MH. Long-term outcomes after endoscopic ultrasonography-guided gallbladder drainage for acute cholecystitis. Endoscopy. 2014;46(8):656–61.

    Article  PubMed  Google Scholar 

  59. Penas-Herrero I, de la Serna-Higuera C, Perez-Miranda M. Endoscopic ultrasound-guided gallbladder drainage for the management of acute cholecystitis (with video). J Hepatobiliary Pancreat Sci. 2015;22(1):35–43.

    Article  PubMed  Google Scholar 

  60. de la Serna-Higuera C, Perez-Miranda M, Gil-Simon P, Ruiz-Zorrilla R, Diez-Redondo P, Alcaide N, Sancho-del Val L, Nunez-Rodriguez H. EUS-guided transenteric gallbladder drainage with a new fistula-forming, lumen-apposing metal stent. Gastrointest Endosc. 2013;77(2):303–8.

    Article  PubMed  Google Scholar 

  61. Widmer J, Alvarez P, Gaidhane M, Paddu N, Umrania H, Sharaiha R, Kahaleh M. Endoscopic ultrasonography-guided cholecystogastrostomy in patients with unresectable pancreatic cancer using anti-migratory metal stents: a new approach. Dig Endosc. 2014;26(4):599–602.

    Article  PubMed  Google Scholar 

  62. Binmoeller KF, Shah J. A novel lumen-apposing stent for transluminal drainage of nonadherent extraintestinal fluid collections. Endoscopy. 2011;43(4):337–42.

    Article  CAS  PubMed  Google Scholar 

  63. Moon JH, Choi HJ, Kim DC, Lee YN, Kim HK, Jeong SA, Lee TH, Cha SW, Cho YD, Park SH, et al. A newly designed fully covered metal stent for lumen apposition in EUS-guided drainage and access: a feasibility study (with videos). Gastrointest Endosc. 2014;79(6):990–5.

    Article  PubMed  Google Scholar 

  64. Niederhuber JE, Brennan MF, Menck HR. The National Cancer Data Base report on pancreatic cancer. Cancer. 1995;76(9):1671–7.

    Article  CAS  PubMed  Google Scholar 

  65. Warshaw AL, Fernandez-del Castillo C. Pancreatic carcinoma. N Engl J Med. 1992;326(7):455–65.

    Article  CAS  PubMed  Google Scholar 

  66. Wu Y, Tang Z, Fang H, Gao S, Chen J, Wang Y, Yan H. High operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. J Surg Oncol. 2006;94(5):392–5.

    Article  PubMed  Google Scholar 

  67. Spiliotis JD, Datsis AC, Michalopoulos NV, Kekelos SP, Vaxevanidou A, Rogdakis AG, Christopoulou AN. High operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. J Surg Oncol. 2007;96(1):89–90.

    Article  PubMed  Google Scholar 

  68. Sethi A, Ellrichmann M, Dhar S, Hadeler KG, Kahle E, Seehusen F, Klapper W, Habib N, Fritscher-Ravens A. Endoscopic ultrasound-guided lymph node ablation with a novel radiofrequency ablation probe: feasibility study in an acute porcine model. Endoscopy. 2014;46(5):411–5.

    Article  PubMed  Google Scholar 

  69. Goldberg SN, Mallery S, Gazelle GS, Brugge WR. EUS-guided radiofrequency ablation in the pancreas: results in a porcine model. Gastrointest Endosc. 1999;50(3):392–401.

    Article  CAS  PubMed  Google Scholar 

  70. Carrara S, Arcidiacono PG, Albarello L, Addis A, Enderle MD, Boemo C, Campagnol M, Ambrosi A, Doglioni C, Testoni PA. Endoscopic ultrasound-guided application of a new hybrid cryotherm probe in porcine pancreas: a preliminary study. Endoscopy. 2008;40(4):321–6.

    Article  CAS  PubMed  Google Scholar 

  71. Kushibiki T, Hirasawa T, Okawa S, Ishihara M. Responses of cancer cells induced by photodynamic therapy. J healthc Eng. 2013;4(1):87–108.

    Article  PubMed  Google Scholar 

  72. Chan HH, Nishioka NS, Mino M, Lauwers GY, Puricelli WP, Collier KN, Brugge WR. EUS-guided photodynamic therapy of the pancreas: a pilot study. Gastrointest Endosc. 2004;59(1):95–9.

    Article  PubMed  Google Scholar 

  73. Yusuf TE, Matthes K, Brugge WR. EUS-guided photodynamic therapy with verteporfin for ablation of normal pancreatic tissue: a pilot study in a porcine model (with video). Gastrointest Endosc. 2008;67(6):957–61.

    Article  PubMed  Google Scholar 

  74. Di Matteo F, Martino M, Rea R, Pandolfi M, Rabitti C, Masselli GM, Silvestri S, Pacella CM, Papini E, Panzera F, et al. EUS-guided Nd:YAG laser ablation of normal pancreatic tissue: a pilot study in a pig model. Gastrointest Endosc. 2010;72(2):358–63.

    Article  PubMed  Google Scholar 

  75. Di Matteo F, Martino M, Rea R, Pandolfi M, Panzera F, Stigliano E, Schena E, Saccomandi P, Silvestri S, Pacella CM, et al. US-guided application of Nd:YAG laser in porcine pancreatic tissue: an ex vivo study and numerical simulation. Gastrointest Endosc. 2013;78(5):750–5.

    Article  PubMed  Google Scholar 

  76. Chang KJ, Nguyen PT, Thompson JA, Kurosaki TT, Casey LR, Leung EC, Granger GA. Phase I clinical trial of allogeneic mixed lymphocyte culture (cytoimplant) delivered by endoscopic ultrasound-guided fine-needle injection in patients with advanced pancreatic carcinoma. Cancer. 2000;88(6):1325–35.

    Article  CAS  PubMed  Google Scholar 

  77. Mulvihill S, Warren R, Venook A, Adler A, Randlev B, Heise C, Kirn D. Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther. 2001;8(4):308–15.

    Article  CAS  PubMed  Google Scholar 

  78. Hecht JR, Bedford R, Abbruzzese JL, Lahoti S, Reid TR, Soetikno RM, Kirn DH, Freeman SM. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res. 2003;9(2):555–61.

    CAS  PubMed  Google Scholar 

  79. Chang KJ, Lee JG, Holcombe RF, Kuo J, Muthusamy R, Wu ML. Endoscopic ultrasound delivery of an antitumor agent to treat a case of pancreatic cancer. Nat Clin Pract Gastroenterol Hepatol. 2008;5(2):107–11.

    Article  PubMed  Google Scholar 

  80. Chang KJ, Irisawa A, Group EUSW. EUS 2008 Working Group document: evaluation of EUS-guided injection therapy for tumors. Gastrointest Endosc. 2009;69(2 Suppl):S54–8.

    Article  PubMed  Google Scholar 

  81. Hecht JR, Farrell JJ, Senzer N, Nemunaitis J, Rosemurgy A, Chung T, Hanna N, Chang KJ, Javle M, Posner M, et al. EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study. Gastrointest Endosc. 2012;75(2):332–8.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Herman JM, Wild AT, Wang H, Tran PT, Chang KJ, Taylor GE, Donehower RC, Pawlik TM, Ziegler MA, Cai H, et al. Randomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results. Journal Clin Oncol. 2013;31(7):886–94.

    Article  CAS  Google Scholar 

  83. Citrin D, Camphausen K, Wood BJ, Quezado M, Denobile J, Pingpank JF, Royal RE, Alexander HR, Seidel G, Steinberg SM, et al. A pilot feasibility study of TNFerade biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer. Oncology. 2010;79(5-6):382–8.

    Article  PubMed  Google Scholar 

  84. Akiyama Y, Maruyama K, Nara N, Hojo T, Cheng JY, Mori T, Wiltrout RH, Yamaguchi K. Antitumor effects induced by dendritic cell-based immunotherapy against established pancreatic cancer in hamsters. Cancer Lett. 2002;184(1):37–47.

    Article  CAS  PubMed  Google Scholar 

  85. Irisawa A, Takagi T, Kanazawa M, Ogata T, Sato Y, Takenoshita S, Ohto H, Ohira H. Endoscopic ultrasound-guided fine-needle injection of immature dendritic cells into advanced pancreatic cancer refractory to gemcitabine: a pilot study. Pancreas. 2007;35(2):189–90.

    Article  PubMed  Google Scholar 

  86. Hirooka Y, Itoh A, Kawashima H, Hara K, Nonogaki K, Kasugai T, Ohno E, Ishikawa T, Matsubara H, Ishigami M, et al. A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer. Pancreas. 2009;38(3):e69–74.

    Article  CAS  PubMed  Google Scholar 

  87. Endo H, Saito T, Kenjo A, Hoshino M, Terashima M, Sato T, Anazawa T, Kimura T, Tsuchiya T, Irisawa A, et al. Phase I trial of preoperative intratumoral injection of immature dendritic cells and OK-432 for resectable pancreatic cancer patients. J Hepatobiliary Pancreat Sci. 2012;19(4):465–75.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, University of Rochester Medical Center & Strong Memorial Hospital, Rochester, NY, USA

    Truptesh H. Kothari M.D., M.S., Shivangi T. Kothari M.D. & Vivek Kaul M.D., F.A.C.G., F.A.S.G.E.

  2. Center for Advanced Therapeutic Endoscopy, URMC/Strong Memorial Hospital, 601 Elmwood Ave./Box 646, Rochester, NY, 14642, USA

    Truptesh H. Kothari M.D., M.S., Shivangi T. Kothari M.D. & Vivek Kaul M.D., F.A.C.G., F.A.S.G.E.

Authors
  1. Truptesh H. Kothari M.D., M.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shivangi T. Kothari M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vivek Kaul M.D., F.A.C.G., F.A.S.G.E.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vivek Kaul M.D., F.A.C.G., F.A.S.G.E. .

Editor information

Editors and Affiliations

  1. Salt Lake City, Utah, USA

    Douglas G. Adler

Video Legend

Additional interventional EUS procedures (MOV 187183 kb).

Acknowledgement

The authors wish to thank Glen Hintz, MS, Assoc Prof and Interim Chair of the School of Art, College of Imaging Arts & Sciences, Rochester Institute of Technology (RIT), for his time and effort in creating the animation clips for the video associated with this chapter.

Financial Disclosure The authors have no relevant financial disclosures.

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Kothari, T.H., Kothari, S.T., Kaul, V. (2016). Additional Interventions in EUS. In: Adler, D. (eds) Advanced Pancreaticobiliary Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-26854-5_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26854-5_16

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26852-1

  • Online ISBN: 978-3-319-26854-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation